Also congratulations to Hoda Kooshapour @kooshapour. These two NAR papers reveal RNA-mediated regulation of Salmonella in macrophages.
https://t.co/PWtC1lwvhI
Now official: We have another opening for a fully funded #PhDposition in the Beusch lab (https://t.co/xJgHDSZEZ7) at
the University of Würzburg! More details here: https://t.co/2QXJKKLskx If you or someone you know is curious about #splicing please apply. #RNAbiology
Reasoning models are the future...
That's why we added two more to Otio:
- @deepseek_ai R1 distilled
- @OpenAI o3-mini
For tasks that require some extra horsepower 🐎
Interested in collecting, sharing, and interacting with large collections of bacterial functional genomics data (RNA-seq, Tn-seq/TraDIS, etc.)? Check out our new web platform, Micromix, with case studies for Salmonella and Bacteroides! Thread 1/n
https://t.co/ClLRKgtrFz
I am excited to finally share this preprint from @JoergLab.
We've developed a reporter assay to enable high throughput discovery of carriers for ASOs into bacteria.
This was a challenging and exciting journey for me, from MedChem/ChemBio into Mol/SynBio.
We determined gene essentiality in 13 Enterobacteriaceae including E. coli, Salmonella and Klebsiella strains, and find ~1/3 of the essential genome is variable -- but! there's no evidence for genus-specific essential genes, implying rapid turnover https://t.co/dy0ovi4WE4
🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬https://t.co/2jDc93D4Sr #Mitochondria#microscopy#microfluidics#mtDNA
We are organising a mini conference on the diverse applications of Antisense oligonucleotides to manipulate bacteria. Apart from a stellar line-up, Würzburg itself offers a beautiful setting. Spread the word and join us.
@UWMadisonRNA @JoergLab@PeterFineran Proteins with HTH domains are primarily known for their role in DNA recognition and binding. Even the few exceptions that have RNA-binding capacity, still primarily have DNA-binding function. (For example, PhoP)
So as Jörg mentioned it’s still a fascinating on-going research🤩
Interested in RNA-targeting antisense technologies to manipulate and kill bacteria? Come join us in Würzburg this September -- registration is open (and free!) https://t.co/Pe7WecxYmF
A systematic comparison of antibacterial antisense oligomers of distinct nucleotide mimics based on in vitro and in vivo methods to evaluate ASO uptake, target pairing and bacterial growth inhibition. https://t.co/npxBhxN4jz
An analysis of around 1,500 blood proteins has identified biomarkers that can be used to predict the risk of developing dementia up to 15 years before diagnosis https://t.co/r9oKxt4J3S
Just published📯: while Salmonella-infected intestinal epithelial cells are exfoliated into the gut lumen in adults, nonprofessional efferocytosis of infected cells by neighboring enterocytes may contribute to the antibacterial host response in neonates (https://t.co/6gji2wBFWL).
Happy to share our latest work, spearheaded by @prezzag in collaboration with @BeiselLab@Helmholtz_HIRI and just out @PNASNews.
We set up a CRISPRi system in B. thetaiotaomicron and used it to screen sRNAs for their functions. [1/5]
https://t.co/VqDNGLK5EZ
So excited to share that our preprint discovering KhpA/KhpB as broad RBPs in fusobacteria are now out in @NAR_Open. Big thanks to my supervisor @JoergLab and @AnkeSparmann, TeamFuso @PonathF , as well as all supports from Vogel Lab @Helmholtz_HIRI!
https://t.co/Y7cKrVUUWd
Job Alert🚨. We are looking for a postdoc with a background in #virology and a research assistant / lab manager. Be part of an #ERCfunded research project and join a fantastic team
working on RNA-protein interactions at the virus-host interface @goetheuni@UK_Frankfurt
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