Falk Ponath

[Falk Ponath @PonathF]

2 is better than 1 – Our recent work in #mBio identifies a FoxJ as a 2nd σE-dependent #sRNA in #Fusobacterium. Not only does FoxJ act as negative regulator but also positively regulates some mRNA targets - offering a new trick for σE-dependent sRNAs. https://t.co/AsrEYVv8gN

[Cell Host & Microbe @cellhostmicrobe]

Small RNA w/big roles in colonization
@MoualiYoussef @StrowigLab characterize RNA landscape of Segatella copri. ID small RNA regulator essential for colonization & whose expression is regulated by metabolism of dietary components by S. copri
https://t.co/KJp0upeY3K

[Falk Ponath @PonathF]

Check out the spectacular work led by @MoualiYoussef - giving insights into #sRNA regulation in the unexplored #Segatella/#Prevotella impacting metabolism and interactions with the host & commensals in the gut🦠

[CJohnstonLab @CJohnstonLab1]

New research from @BullmanLab /@CJohnstonLab1, with superstar 1st author @mzepedar, out now in
@Nature pinpoints “high-risk” subtype of Fusobacterium nucleatum that dominates the colorectal
cancer (CRC) niche in human patient's
Link : https://t.co/v4iQZmkqDA
Tweet🧵below:

[Susan Bullman @BullmanLab]

A new study from Bullman and @CJohnstonLab1 @fredhutch out today @Nature. We identify a 'high-risk' clade of F. nucleatum that dominates the human CRC niche. Huge congrats to the amazing first author @mzepedar and the incredible team.
🧵 from Chris 👇
https://t.co/IO9RGK6365

[Falk Ponath @PonathF]

@_Daniel_Ryan_ @NatureMicrobiol Great work, Daniel - congrats!🥳

[Westermann lab @WestermannLab]

1/5: Molecular intricacies of gut bacteria! 🧬 Our study in @NatureMicrobiol , with colleagues from @Helmholtz_HIRI, @DeutschbauerLab , & @LBarquist groups, unveils B. thetaiotaomicron's transcriptional landscape across 15 gut conditions. https://t.co/NoX3tRSOdM

[Lars Barquist @LBarquist]

Very excited to finally see our study of global RNA stability in Salmonella out today in
@PNASnews, where we use Bayesian statistical modeling to show bacterial transcripts have subminute half-lives, far shorter than previously thought. https://t.co/9m1DVnIkOM 1/n

[Jens Puschhof @JensPuschhof]

Another great collaboration with @Axel_R_Huber, @Cayetanopm, @JoskeUbels, @HansClevers, @BoxtelLab and many others. Random forest trained with #organoid #colibactin mutations => identification of pks-linked mutations in every 8th #colorectal tumor genome! https://t.co/HUbf9A3NCf.

[Falk Ponath @PonathF]

And for additional information see our previous work identifying the sigma E regulon and the first sRNA FoxI alongside some genetic tools for #Fusobacterium : https://t.co/Pk7cQUMxRB

[Falk Ponath @PonathF]

2 is better than 1 – Our recent work in #mBio identifies a FoxJ as a 2nd σE-dependent #sRNA in #Fusobacterium. Not only does FoxJ act as negative regulator but also positively regulates some mRNA targets - offering a new trick for σE-dependent sRNAs. https://t.co/AsrEYVv8gN

[Falk Ponath @PonathF]

Also, a big shout-out to @SciGraphix for the amazing work on these beautiful figures.

[Westermann lab @WestermannLab]

Happy to share our latest work, spearheaded by @prezzag in collaboration with @BeiselLab @Helmholtz_HIRI and just out @PNASNews.
We set up a CRISPRi system in B. thetaiotaomicron and used it to screen sRNAs for their functions. [1/5]

https://t.co/VqDNGLK5EZ

[Falk Ponath @PonathF]

#Fusobacterium harboring KH-domain containing #RBP - have a look at this great work led by @yanzhu0329 putting great effort into establishing a broadly applicable pulldown method for RBP identification using #sRNAs & uncovering an ethanolamine-dependent phenotype for KhpB/A

[Yan Zhu @yanzhu0329]

So excited to share that our preprint discovering KhpA/KhpB as broad RBPs in fusobacteria are now out in @NAR_Open. Big thanks to my supervisor @JoergLab and @AnkeSparmann, TeamFuso @PonathF , as well as all supports from Vogel Lab @Helmholtz_HIRI!
https://t.co/Y7cKrVUUWd

[Mathias Munschauer @M_Munschauer]

Proud to present SHIFTR, a novel platform for region-specific RNA interactome discovery developed by fantastic PhD student @jensaydin 👨‍🔬 in my group, now published in @NAR_Open:
1/8

https://t.co/3NI4444Ppl

[Yan Zhu @yanzhu0329]

A new preprint of my PhD project @JoergLab working with TeamFuso @PonathF and Valentina Cosi, identifying two KH domain proteins-KhpA and KhpB as broad RBPs in Fusobacterium nucleatum.

[Daniel J. Slade @TheSladeLab]

Happy to share our latest work: Fusobacterium are naturally competent through Type IV pili. Great, concise study led by @blake_e_sanders and others not on twitter. We discovered it, now you go figure out what to do with it. https://t.co/f6Qrw0mUDR

[Georg Gasteiger @GeorgGasteiger]

A conveyor belt of DCs: FLT3L regulates the spatiotemporal cascade of DC-development in LNs. Fascinating work from @Kamulab @ugur_milas out @ImmunityCP, great teamwork @Wue_SI @dominic_grun @AE_Saliba - open access https://t.co/0NWv7L51x5

[Chandradhish Ghosh @chandradhish]

I ventured into the new world of RNA at @JoergLab with great support from @HoebartnerLab @LBarquist @jakobjung & the other co-authors!

Preprint:

A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics https://t.co/U8vi4QEAD1

[Philip Adams @DrPhilipAdams]

First paper from the Adams lab @NICHD_NIH is out @NatureComms!
We comprehensively mapped RNA and characterized transcription termination in the Lyme pathogen B. burgdorferi —
hundreds of truncated transcripts and potential regulators!

https://t.co/ebmZpBDzo1