Constance Thibault

Medical oncologist, Urologic Oncology @HopitalPompidou @APHP Paris (France)

[OncoDaily GU @OncoDailyGU]

NEMIO evaluated neoadjuvant ddMVAC + durvalumab ± tremelimumab in cisplatin-eligible localized MIBC.

113/119 patients underwent cystectomy. pCR was 47.8% overall: 49.1% with ddMVAC + durvalumab and 46.6% with tremelimumab.

Tremelimumab added toxicity without clear added pCR benefit.

@laconss @y_loriot @phil_barthelemy @Jafrac2 @FrancoisAudet

https://t.co/8QA78ultDi

#BladderCancer #GUOncology #OncoDaily

[Daniel E Spratt @DrSpratticus]

#ASCO26
The PROTEUS trial results are now online...buckle up as we wait to see the full presentation. This is going to be a trial that is likely highly controversial until the full results are published.

Some may call this a homerun, others may call this the largest negative trial @ASCO 2026. Up to you to interpret!

@urotoday @EricTopol @DrChoueiri @neerajaiims @ASCO @US_FDA @NCCN @myESMO @ASTRO_org @PCF_Science @declangmurphy @mcuban

[Caio Suartz @CSuartz]

Just published in European Urology Oncology, our paper on ctDNA in bladder cancer. A noninvasive biomarker that could nos ajudar to reflects tumor burden, predicts treatment response, and identifies recurrence earlier than standard methods. Take a look 🧵

[Caroline Fourest @CarolineFourest]

Courage aux Iraniennes, courage aux Iraniens,
vous êtes inouïs.
Que tous les médias se réveillent, c’est un soulèvement qui peut changer notre monde et notre génération.
Et il a besoin de nos regards.
@femmeazadi
#AllEyesOnIran

[Association Femme Azadi @femmeazadi]

Des millions d’Iraniens sont dans la rue pour appeler au retour de Pahlavi.
Le régime est en train de couper Internet afin de massacrer à huis clos.
Nous avons besoin de l’attention internationale, maintenant ! Sortez de votre léthargie, bordel !!!!!

[Morgan Roupret @MRoupret]

At @myESMO #esmo2025 Berlin, I had the privilege to present the #ALBAN trial (GETUG–AFU 37), an academic phase III study led by @AFUrologie & @GETUG_Unicancer @LaCarine1 together with my outstanding co-PI @y_loriot ,co-investigators @PignotG @champiatMD @PrRomainMATHIEU @ThoSeisen @laconss @UrologieParis and many others across 🇫🇷🇧🇪🇪🇸.
Atezolizumab + BCG did not improve EFS vs BCG alone (HR 0.98; 95% CI 0.71–1.36).
The result was negative across all subgroups, including CIS.
Higher ≥G3 TRAEs were observed in the combination arm.
These findings highlight that in localized #BladderCancer, systemic toxicity assessment remains a key endpoint to balance benefit and risk.
Proud of this collective academic journey started in 2017 — despite the global BCG shortage and COVID-19 — and now published in @Annals_Oncology
📄 https://t.co/xY0GS1Z6dY with the financial support of @Roche
#NMIBC #ESMO25 #OncoUrology #ClinicalResearch @AFUrologie @afufuro @GETUG_Unicancer #EAUguidelines @Uroweb @AmerUrological @ASCO @Uromigos @tompowles1 @DrChoueiri

[Stephen V Liu, MD @StephenVLiu]

This is a major story from #ASCO25. Randomized phase 3 trial of time of day of immunotherapy infusion. Randomized to infusion before or after 3pm. Early infusion far superior: PFS 11.3 vs 5.7 HR 0.42, OS HR 0.45! Impactful, pragmatic, not costly. This should be a bigger story.

[Gabriel Malouf @GabrielMalouf]

Happy to share the team latest investigation of BIONIK trial showing unexpectedly that angiogenic signature is associated with response to immunotherapy in ccRCC, against the current dogma! @igbmc thanks to @OudardStephane https://t.co/lc0iC4Yzef

[Pavlos Msaouel @PavlosMsaouel]

1/5 Sharing our @CCR_AACR work establishing serum CA-125 as a biomarker for #RenalMedullaryCarcinoma. This is now the first cancer-associated blood biomarker to become standard of care and used globally for a #kidneycancer : https://t.co/L5DDOOtzXC @TheVFoundation @renalmedullary

[Constance Thibault @laconss]

@DrYukselUrun @ERPlimackMD @ASCO @OncoAlert @MikeSerzanMD @drenriquegrande @crisbergerot Indeed ! Amazing discussion from @ERPlimackMD raising tow major the questions : 1/ Is GemCisDurva a better option than ddMVAC followed by adj Nivo for non responder patients
2/ Do patients with ypT0 after GemCisDurva need adj Durva ?

[Álvaro Pinto @dralvaropinto]

FDA Approves Subcutaneous Nivolumab in Advanced or Metastatic Solid Tumors https://t.co/ivC9D9elug

[BJU International @BJUIjournal]

Comparative effectiveness of iRARC vs. ORC for #BladderCancer: findings from a real life study show better perioperative outcomes with similar cancer control and ureteroileal stricture outcomes after iRARC
@ThoSeisen
https://t.co/WnBILv2xVf

[Yüksel Ürün @DrYukselUrun]

SBRT for localized prostate cancer: Game-changing results!

A Phase 3 trial shows SBRT is non-inferior to standard radiotherapy for achieving freedom from clinical/biochemical failure. Late toxicity rates were similar. Treatment completed in 5 fractions vs. 39 for CRT. SBRT offers faster treatment with similar efficacy!

#ProstateCancer #Radiotherapy #Oncology #SBRT @OncoAlert

[Gautier Marcq @gautiermarcq]

Just in 👉 @JCO_ASCO Benefit of Whole-Pelvis Radiation ☢️ for Patients With #MIBC
https://t.co/uY8XqgrCF8

👇👇👇TWEETORIAL 👇👇👇

[James Lucas @JamesLucasIT]

Thread of satisfying photos for perfectionists

1. Moon bridge

[Tom Powles @tompowles1]

The EMA has approved Enfortumab Vedotin and pembrolizumab for 1st line urothelial cancer. It supersedes 1st platinum based therapy as the new standard of care in Europe. https://t.co/vn4Tp2Racf

[Álvaro Pinto @dralvaropinto]

J&J's Balversa earns EU nod as first precision therapy for FGFR3-altered bladder cancer https://t.co/cqZxQnkUCF

[François d’Estais @fdestais]

C’est déjà la fin de ces Jeux Olympiques historiques. 💔

On a vécu des moments d’émotion et de beauté absolument surréalistes. Alors je vous propose de les revivre ensemble !

THREAD des moments sportifs les plus marquants de ces Jeux de #Paris2024. 👇

[Constance Thibault @laconss]

@MathieuSlama C’est pas du nationalisme. C’est du patriotisme ! Comme dirait Romain Gary: « Le patriotisme c’est l’amour des siens. Le nationalisme c’est la haine des autres ». Mais apparemment, vous avez un cœur de pierre en plus d’être un gros rabat joie

[Martyn Ziegler @martynziegler]

France just won the #Paris2024 gold medal in rugby sevens and then did this !!!