Dr. Kevin HUANG

I knew I could do it.

[Scripps Research @scrippsresearch]

A new @NatureComms study from Jiang Zhu's lab reports a structure-guided strategy to stabilize influenza hemagglutinin (HA) trimers for nanoparticle vaccines. In preclinical models, the nanoparticles showed prolonged lymph node retention and elicited more robust immune responses.

More: https://t.co/Ax0kIHi3us

[Molecular Therapy Family of Journals @MolTherapy]

Human T Cell Engineering via Serial Delivery of mRNA Encapsulated within Lipid Nanoparticles https://t.co/1NxuenrnQ0 #MTNA

[Cell Reports Medicine @CellRepMed]

Online now: CD8+ stem cell-like memory T cells: Unveiling the potential for next-generation vaccination strategies https://t.co/TRMFuu8x7k

[Molecular Therapy Family of Journals @MolTherapy]

Novel lipid nanoparticle in a mRNA cancer vaccine drives tumor control via type I IFNs and effector CD8+ T cells https://t.co/FU49aE1FAg #MTNA

[nature @Nature]

China's biotechnology companies are producing medicines at a speed and cost that has drawn interest from the world’s largest pharmaceutical groups

https://t.co/6v1yobHgrg

[Molecular Therapy Family of Journals @MolTherapy]

Building better binders: De novo generation of TCR-like antibodies specific to oncogenic KRAS https://t.co/uEDvNWhOV4 #genetherapy #celltherapy

[Nature Biomedical Engineering @natBME]

Intracellular protein binders for imaging, control and future therapeutics https://t.co/ffkCTV7pVb

[Waggoner Lab @LabWaggoner]

A genome-wide map of the genetic network in monocytes that regulates type I interferon induction by the cGAS-STING pathway @scisignal
https://t.co/hN9Ag3oKCQ

[Trends in Pharmacological Sciences @TrendsinPharma]

Lysosome-targeted protein degradation platforms for spatiotemporally controlled degradation https://t.co/82tMOcxfjC

[Molecular Cell @MolecularCell]

Host transcriptional corepressor TLE1 is commonly exploited by RNA viruses for replication https://t.co/MnjKkNBDAe

[Cell @CellCellPress]

In the latest issue! Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system https://t.co/eJRTKqCvDe

[nature @Nature]

Nature research paper: Membranolytic peptide programs immunogenic cell death for cancer therapy

https://t.co/F0SKoZqwtR

[ShorterLab @ShorterLab]

An ER stress-responsive RNA rheostat for programmable gene and mRNA therapies: Cell Chemical Biology https://t.co/mgmML4gxkP

[good papers @paperperday]

Mechanism underlying the high regulatory performance of the doxycycline riboswitch G12

"capture-SELEX: RNA itself immobilized to a bead-bound oligo, while the ligand is free. Candidates only elute if binding the ligand triggers a conformational change"

https://t.co/iHl8D1ftDl

[nature @Nature]

Nature research paper: Rational design of disordered proteins for sequence–function investigation

https://t.co/BRWg6DS0Er

[Science Advances @ScienceAdvances]

Researchers have identified the receptor CD36 as essential for human sapovirus infection alongside bile acids, which help the virus enter intestinal cells.

This mechanism opens potential avenues for antiviral treatment and vaccine development. https://t.co/cnkF04C7UQ

[Science Magazine @ScienceMagazine]

Researchers in Science report the development of a general-purpose biomedical AI agent that can help automate biomedical research workflows.

The authors say their results point “toward a future in which AI agents work alongside human researchers to accelerate biomedical discovery from basic research to translation.”

Learn more: https://t.co/UdLl5uxMQe

[Nature Chemical Biology @nchembio]

Small molecules can covalently modify proteins and generate covalent neoantigens, triggering immune responses. Now, a chemoproteomic platform enables the discovery of covalent neoantigens, which can also be harnessed for immunotherapeutic applications

https://t.co/6ebbp7YycW

[CDC @CDCgov]

Sharks thrive in the right habitat. You can, too.
Healthy living isn't one big decision. It's the small choices you make every day.
✔️ Eat nutritious foods.
✔️ Be physically active.
✔️ Get enough quality sleep.
✔️ Stay up to date on recommended screenings.
✔️ Use broad-spectrum sunscreen with an SPF of 15 or higher.
✔️ Avoid all tobacco use.
✔️ Drink less alcohol.
Together, these healthy choices can help reduce your risk of chronic diseases, including heart disease, type 2 diabetes, and some cancers, and support a longer, healthier life.
This #SharkWeek, choose one healthy step. Small changes today can help protect your health for years to come.
#SharkWeek #ChronicDisease #GetActive #EatRealFood

[Scientific American @sciam]

While “protein maxxing” is all the rage, reducing your protein intake could add years to your life
https://t.co/SWaByWd1tP