Lindsey Montefiori

Postdoc at St. Jude interested in transcriptional regulation and cancer

[Lindsey Montefiori @LeMonte63]

@jkobject How do the openers and shufflers know where to go?

[Matthias Mann Lab @labs_mann]

Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. https://t.co/Fozb4LfdQk

[Matthias Mann Lab @labs_mann]

1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
https://t.co/5RJ0nVoQ81

[Anders Sejr Hansen @Anders_S_Hansen]

Going from the discovery of epigenetic silencing of CTCF insulators https://t.co/Qyhnk32yKq to aberrant E-P looping https://t.co/RCzXjfZDPB to a successful clinical trial https://t.co/lcO3fZHRj9 all from Brad Bernstein's lab

[Dmitry Penzar @dmitrypenzar]

10/ Remarkable. We are still way far from trully decyphering regulatory logic. For now, we are working with sophisticated, yet surprisingly easy-to-break, dictionaries.

[Katie Galloway @GallowayLabMIT]

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

[ElowitzLab @ElowitzLab]

Just out: our forward-looking essay on mRNA “delivery cells”—engineered cells that could locally manufacture mRNA at disease sites within the body and transfer it to target cells in extracellular vesicles.

[Jason Buenrostro @JD_Buenrostro]

Can we control cells by forcing TFs to collaborate?

Interested? Read our preprint! An awesome collaboration with @cgersbach, @christian_mcam, @IGVFConsortium, led by @Rachel_E_Savage:
https://t.co/8az4zt9nlr

🧵

[Lindsey Montefiori @LeMonte63]

Very cool finding. Depending on how you look at it, is our genome remarkably robust or remarkably fragile? 🤔

[Nitzan Gonen @gonen_nitzan]

1/n
🤩 Beyond excited to share our recent paper, published today @NatureComms!! 🤩
This study represents, in my view, one of the most striking phenotypes we ever found with really important findings and implications.

https://t.co/zG6QqPPEua

[William Gibson @wgibson]

What if a small molecule could activate a transcription factor program in one cell type and destroy the same pathway in another? In our new preprint, we describe one such story on bifunctional molecules that toggle between transactivation and repression.

[Simon Kohl @saakohl]

Today we're launching Latent-Y: the world's first autonomous agent for drug design, lab-validated end to end.

Give it a research goal. Latent-Y reasons, designs, iterates, and delivers lab-ready antibodies, autonomously or collaboratively, with the biological reasoning of a PhD protein design expert.

Technical report: https://t.co/E7IHfkvvD3
Blog post: https://t.co/GfJAfzj0Qx
Apply for access: https://t.co/E0SR9znZiP

[Di Jiang @dijiang319]

Unstructured transcription factor interactions enable emergent specificity | @ScienceMagazine https://t.co/vQric0jGzE

[Julian Pulecio @julian_pulecio1]

Are the enhancer regions that control the expression of lineage genes established from early embryonic stages or do they gain their transcriptional potential along differentiation? Today in @CellGenomics we address this question: https://t.co/atWlKbDUVq 1/15🧵

[Flora Paldi @flora_paldi]

A few days late in sharing, but but thrilled to share that my postdoctoral work on #3Dgenome and #CellularMemory is now published in @NatureGenet: https://t.co/IVB4dwq33t

[Russell Ryan @RussellJHRyan]

New from us in @CellGenomics: Using FFPE-compatible Hi-C to detect oncogenic rearrangements genome-wide in routine lymphoid cancer biopsies. Congrats to first author pathologist-scientist Jamin Wu, co-senior author Matija Snuderl @NYUGSOM_Path, and @ArimaGenomics.

[Lindsey Montefiori @LeMonte63]

I can imagine a future where it might be a novelty, and a pleasure, to work exclusively with humans

[Lindsey Montefiori @LeMonte63]

🤣

[Anshul Kundaje @anshulkundaje]

A genius recently suggested that we just take our raw data & shove it into Claude Code. And I said no it can't help us cuz it's all about coding stuff & we work on non-coding stuff. Spoke too soon.

[Anshul Kundaje @anshulkundaje]

The @ENCODE_NIH Phase 4 Registry of candidate cis regulatory elements (ccREs) (2.37 million human and 967,000 mouse cCREs) is officially out

https://t.co/uuJAsO334Z

https://t.co/wtCW3beYlv

Congrats to @MooreJillE
@ZhipingWeng & everyone else.

Lots more incoming ...

[Jian Xu @JianXuLab]

Excited to share our new study published online today @CD_AACR. Beyond mutagenesis, we show that LINE-1 locus-specific transcription reshapes 3D genome architecture to control cancer gene expression @JianXuLab @StJudeResearch
https://t.co/oEmNj8IGf9

[Cigall Kadoch @CKadoch]

A New Year, a new paper out on Jan 1 in @ScienceMagazine ! Congratulations to @SiddhantUJain and all our co-authors and collaborators! This study answers a longstanding question in our field regarding recruitment of chromatin regulatory machinery and provides a powerful new framework for development of precision medicines in #cancer and beyond! @kadochlab @alex2110x @hhmi_science @DanaFarberNews @DanaFarber
https://t.co/nUE3Fs2acw
#generegulation #chromatin #cancer #therapeutics #basicscience #BAFcomplex #mSWISNF #chromatinremodeling