parth

Expanding human agency & machine capability. Building Imparting @aevonehq

[parth @liminalbits]

agentic rx is here

[Benjamin Jack, MD @bjackmd]

I'm an ER physician, and I built a way to get a real prescription through Claude Code - or any AI agent.

[Parimal @Fintech03]

In the late 1890s, inside a bustling lab on Bowbazar Street in Calcutta, a young Indian medical student sat in total darkness, his eyes heavily bandaged after a horrific lab acid explosion had prematurely ended his medical career. Rather than surrendering to despair, he used his heightened sense of smell & sound to launch a parallel industrial empire, inventing a hair elixir so legendary that it birthed the 1st science-fiction story in the Bengali language & setting up a homemade recording studio that would capture the voices of the revolution before the West could patent them.

The history of early Indian consumer enterprise has no character more cinematic than Hemendra Mohan Bose (popularly known as H. Bose). After his tragic accident forced him out of medical college, Bose pivoted entirely to organic chemistry & perfumery. In 1894, he formulated Kuntaline Hair Oil, a brilliant, non-greasy, deeply aromatic hair elixir infused with pure natural extracts. But Bose was not just a chemist; he was perhaps the most brilliant, quirky & avant-garde marketing wizard independent India had ever seen.

To sell his Swadeshi hair oil against deeply entrenched British competitors, Bose pulled off a masterstroke of product placement. He instituted the Kuntalin Puraskar (Kuntaline Awards), inviting writers from across the country to submit short stories. The prize money was massive, but there was 1 highly eccentric, genius catch: the narrative had to seamlessly feature Kuntaline Hair Oil/his Delkhosh perfume within the plot w/o making it look like an overt commercial.

In 1896, an anonymous entry won the very first Kuntalin Puraskar. Titled Nirrudesher Kahini (Story of the Untraceable), it told the story of a terrifying cyclone bearing down to completely annihilate Calcutta. In a desperate bid to save his ship from the monstrous cyclonic waves, the hero remembers a scientific theory about oil smoothing out turbulent waters & dumps his massive cargo of Kuntaline Hair Oil into the ocean, instantly calming the sea & saving the city.

The anonymous author who wrote this product-placed story? None other than the legendary physicist Sir Jagadish Chandra Bose, writing what is now recognized as the very 1st science-fiction story in the Bengali language.

Later, a young, unknown writer named Sarat Chandra Chattopadhyay won the same award, launching his historic literary career. But H. Bose's audacity went far beyond print. In 1900, he imported an early Edison Phonograph to privately record his friends. When British recording companies began charging extortionate prices to press records of Indian musicians, Bose weaponized his workshop.

By 1907, he began manufacturing his own wax recording cylinders, launching H. Bose Swadeshi Records. He manually captured & preserved the voices of India's intellectual titans. It was inside H. Bose’s studio that Rabindranath Tagore stood before a brass horn & recorded his very 1st rendition of Bande Mataram. When the British govt aggressively banned the public singing of nationalist anthems, Bose secretly duplicated his Swadeshi cylinders & distributed them across the country in boxes disguised as Kuntaline hair oil shipments.

His son, Nitin Bose, trained in his father's improvised labs, went on to become the pioneering father of Indian cinema technique, inventing the concept of playback singing at New Theatres. Yet today, if we search through the modern digital music & cosmetics landscape, the name of the blind-struck chemist who recorded the soul of the revolution is entirely absent.

The modern entertainment & beauty industries are driven by multi billion dollar streaming algos & synthetic grooming formulas backed by global corporate capital, yet every single time an artist steps up to a microphone to record a track of defiance/a writer creates a world out of raw imagination, the heavy, rhythmic ghost of H. Bose’s wax cylinders still spins in the dark proving that while a foreign empire can try to mute a nation, they can never stop the sound & scent of its freedom.

[parth @liminalbits]

India's new national family health survey just dropped.
>Adult obesity in women rose in 33 of 35 states.
>In Kerala, 1 in 3 men now has high blood sugar.
>Goa's worse.

Diabetes, obesity & hypertension climbing in nearly every state, fastest in the richest ones. NFHS-6 mapped state by state👇
https://t.co/ngPTCDXnwk

[Ministry of Health @MoHFW_INDIA]

#HealthForAll

Union Health Ministry Releases National Family Health Survey – 6

NFHS-6 Reflects India’s Accelerated Progress in Maternal and Child Health, Nutrition and Financial Protection

Institutional Deliveries Reach 90.6%

ANC Coverage increases from 92.6% to 95.9%

Any Vaccine received by Children age 12-23 months remains Consistently High above 96%

95.6% children received most vaccinations through public health facilities as preferred choice

Rotavirus Vaccination Coverage more than Doubled

Primary Healthcare Strengthening Propels India Towards Significant Improvement in Full Immunization Coverage from 83.8% to 87.1%

Child Nutrition Indicators show Improvement with Reduction in Stunting by 17% and Severe Wasting by 32%

Ayushman Bharat-PMJAY and Expanded Health Protection Initiatives Strengthen Financial Security in Healthcare

https://t.co/v7yvAaMCOV

[Internet Archive @internetarchive]

Turns out the real Backrooms were hiding in web archives. 👀

Internet sleuths tracked down the original location of the Backrooms image using the @waybackmachine, proving once again that preserving the web is important for internet history, folklore, and mysteries, too.

[TaraBull @TaraBull]

🚨 This is terrifying. A guy bought a 7-OH pill from a gas station, sent it to a lab for testing, and the results confirm what experts are warning about: it's extremely dangerous and highly addictive.

These "gas station heroin" pills are sold openly as harmless supplements but act like potent opioids on your brain. They can lead to addiction, severe withdrawal, overdose, and serious health damage.

FDA and doctors are sounding the alarm: avoid 7-OH products completely. They're not safe, not natural in these concentrated forms, and way riskier than people think.

If you or someone you know is using this, get help. This stuff is destroying lives.

[parth @liminalbits]

@tidemid Impressive. Guanfacine + Clonidine ?

[Dr. Datta M.D. (Radiology) M.B.B.S. 🇮🇳 @DrDatta_AIIMS]

Done with Indian VCs!👎🏽

Visiting Singapore and US soon guys!

Any connections with healthcare VCs who fund at pre-seed stage to research teams to build new categories of products will be appreciated!

We have raised more from equity free grants by spending 1/10th time of what we spent wasting time with Indian VCs! L aise India mein deeptech banega!

[parth @liminalbits]

BPC-157 is about to enter its public mythology phase.

[Andrew D. Huberman, Ph.D. @hubermanlab]

The new Huberman Lab episode is out: Peptides: The Science, Uses & Safety | Dr. @AbudBakri

0:00 Abud Bakri
3:33 What are Peptides?, Receptors
6:26 BPC-157, Discovery, Animal Proteins
11:19 BPC-157, Animal Data, Regeneration
12:27 Sponsors: Eight Sleep & Lingo
14:51 BPC-157, Regeneration & Healing, Neurological Effects
19:27 Adverse Events, Clinical Trials & Legality of BPC-157
29:41 GLPs & Compounding Pharmacy; Peptides & Gray Market
35:25 Manufacturing, Compounding Pharmacies, Gray Market, Black Market
41:32 Peptides & Tumor Growth?; Angiogenesis
45:17 Sponsor: AG1
47:01 Pharmaceutical Patents, Clinical Trials for BPC-157, Potential Outcomes
54:19 BPC-157 Healing, Patient Experiences
1:01:22 Physician Counsel, FDA Legality, Malpractice
1:07:25 Pinealon, Epithalon, Discovery; Sleep & Cognitive Performance, Risks
1:18:17 Sponsor: Function
1:19:55 Pineal Age Deterioration, Epithalon, Eye Health
1:29:38 Thymus, Age Shrinkage; Thymosin Alpha-1, Immune Function
1:38:13 TB-500; Pet Health; Thymic Peptide Doses, Thymulin, Zinc
1:49:13 Sponsor: LMNT
1:50:33 GHK-Cu (Copper GHK), Collagen
1:55:32 Illness Recovery, Thymic Score, Tool: Blood Test & Immune Cell Counts
2:04:01 Growth Hormone Secretagogues, Age Decline, Cancer Risk, Insulin
2:15:36 GHK-Cu, Topical Cream, Red Light Therapy
2:20:25 GLPs, Discovery, Physical & Cognitive Long-Term Effects, Fertility
2:33:53 Retatrutide; Drug Patents & Nomenclature
2:39:03 Peptides: Women Reproductive Disorders; TBI, Neurologic Effect; Safe Sources
2:45:34 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

Includes paid partnerships.

[Olivia Moore @omooretweets]

Self-driving cars are fun because you never see competing SaaS products having a literal standoff in the street

[parth @liminalbits]

@A_S_L_O I'm interested in the self balancing scooter. That's the AI we need

[pj @BeingPractical]

31 May 2020:
I was on the road, staring at failure at the start of my 40s.

1 June 2020:
6 years back, on this day I started my journey of building Raise (@RaiseTheBarHQ) from zero.

The day before, I held a fancy title of Founder, Managing Director and CEO of a financial services company, was an industry pioneer and a leader, built and scaled a product that redefined how India invested online, that made mutual funds popular, and introduced direct mutual funds to the masses. Built a venture that managed few billions dollars and was possibly valued as much as.

Next day, I had nothing. No titles, No power. No team. No salary, No stocks. Practically made no money from the venture I gave everything to for 3 years to make it a grand success. Founders like me are emotional fools & immature beings who trust easily and take a word as a word, only to realise one day - the world doesn't work the way one thinks it works.

Tried to raise money from venture capital, which I thought would be a easy thing to do but it was not. Almost every VC out there rejected me. Few influential people made raising capital a bit difficult. Many VC & partners who promised term-sheets, stopped responding to emails / chats or just backed out.

All of this happened during peak COVID times. I was staring at failure at the start of my 40s. I had no idea what the future would hold for me. Job was never an option, I am too practical and also much of a straight-talker to survive in a corporate life. I had started up 3 times earlier, and was more or less a failure. Somehow gathered courage to start-up again just because giving up again was never an option.

Times have changed since then!

Today we are a team of ~650+ builders and believers at Raise.

Only thing we care about is building the best consumer experiences across all the products we are building - @DhanHQ @ask_fuzz @Upsurge_club @Stratzy_HQ @FilterCoffeeHQ and few more ventures in insurance, wealth and investing that we are building.

5 years back value of everything was Zero. Today for whatever it means, Raise is a unicorn valued at USD 1.2 Bn. At some point, I was offered good money as some sort of settlement which of course I never took. This is why I say that as founders, some of us are emotional fools who keep taking chances even after losing it all!

Looking back, even after this crazy journey and tons of luck by my side, I am still more of an emotional & introvert founder fool. We are still in our early days of building and are far from where we want to be.

Once again, there's no inspiration or gyan here for anyone. Tu tera dekh le bhai, yahaan mein khud bhagwan ke bharose pe hoon..

I post this just as a reminder to myself - never forget where & how we started from.

More importantly to express my gratitude to all those who stood by me and supported us in my tough times - as co-founders, team members, colleagues, believers, supporters, cheerleaders, well wishers, investors, friends and most importantly as our customers.

Thank you, I wouldn't have made it till here without you 🙏

[Dave W Plummer @davepl1968]

He was the multimillionaire software visionary that created the Zip file format still used almost universally to this day. And now, at the age of just 37, Phil Katz was dead. His life came to an inglorious ending in a lonely hotel room somewhere in Milwaukee County, Wisconsin.

He had a home nearby, and the cops had been summoned to it at least once before when neighbors complained of odors, insects, and mice infesting the neighboring luxury apartments. Once inside, the police were confronted with knee-deep garbage, decaying food scraps, and much more.

When they later found his lifeless body slumped against a nightstand in that dingy south side hotel room, he was still cradling an empty bottle of liquor. A half dozen similar bottles littered the room.

He was completely alone now, having long since been estranged from his family and now virtually a stranger even to the employees of his own company. His body could no longer sustain the abuse from years of chronic alcoholism, and he died alone that night of acute pancreatic bleeding.

The Dark History of Zip Files: you might already know that I wrote the Zip file support that's been in Windows for about 30 years...

But I had nothing to do with the creation of the Zip format, which goes back to Phil Katz. This is his tragic and cautionary tale... as told by me.

I never met Phil before he died. I'd like to think that before he started his descent into darkness, we'd have a lot to talk about.

[V🍀 @verdedraws]

Always liked this one

[𝓒𝓸𝓶𝓶𝓪𝓷𝓭𝓮𝓻 🏴‍☠️ @c0mmandderr]

I don't wanna feel like I'm fighting for civil rights every time I wanna wash up 😭

[ангел𓂀𓋹🪽𖤓 @cleomythra]

‘Hands weaving magnetic-core memory, IBM, Poughkeepsie, New York,’ 1956. Photograph by Ansel Adams.

[Anita Zsurzsan 🇵🇸 🕎 @iamjourjean]

How your email finds Europeans from June to September

[NO CONTEXT HUMANS @HumansNoContext]

I’m not using my free will enough