Excellent paper by @JTAuthor arguing most cases of depression are functional responses to circumstances, not dysfunctions - as most cases of pain are functional responses to bodily harm. This is crucial for healing, as it points us outward, toward the world and how we view it.
@OdedRechavi something else to worry about. 5 days per paper *on average* is impossible, I can confidently say, having published seven myself during my previous reincarnation.
When I read this headline for the first time I read "5 years" not "5 days" and thought "hmmm that actually sounds like a reasonable amount of time to complete a paper"
When critics say “psychiatric genetics hasn’t delivered” what they are really saying is “I have no clue where to start within this complex web of factors that regulate brain development.” Perhaps they were were hoping for a big flashing sign that says “put drug here” 🙄
Reading the literature, it seems as though everything is known. But analyzing practically any dataset yourself quickly reminds you how little we can actually explain.
@BioMickWatson We keep digging and find out there is more to dig. There is a better way. Look to the "East" for a wholistic approach to medicine, but *without* throwing out logic and the scientific method
#scientific_method
yeah, no.
there might be a biotech boom, but really understanding biology especially disease biology is a long way away. we are just scratching the surface and we find that the more we dig, the more there is to dig. we need a paradigm shift in biotech research.
I think he's being very overoptimistic here. Unlike the determinism of engineering, biology is vastly more non-linear with feedback loops and unknown complexity. There will be a revolution in biotech, but not necessarily of the engineering kind and not that soon.
It's all connected... In this study, we show that tiny injuries created deep in the brain's capillary bed can contribute broadly to blood flow impairment by constricting upstream supply vessels. https://t.co/D38oMFbIwD
Our lab as well as students in the class I teach this semester enjoyed tasting the first CRISPR-edited salad greens, in which the myrosinase gene that results in the pungency of raw mustard greens (Brassica juncea) has been disabled, yielding a nutrient-dense, tasty, and attractive, salad without the ‘mustard bomb’. Thank you @PairwisePL for providing the samples!
The science behind the greens: https://t.co/KDef1iwGKK
Disclosure: I am a cofounder of Pairwise Plants along with @JKeithJoung and @zhangf.
Daniel Dennett just published "I've Been Thinking"! In it he discusses his process of “tillosophy”: when you realize you're stuck, deliberately switch to a less intellectually demanding activity (like tilling a field on a farm), as this actually helps move the thinking forward.
There is increasing need to talk about multi-dimensional, different molecular measurements of humans and life - germ line genomics, somatic genomics, transcriptomics, proteomics, metabolomics. But we have a comms issue - what umbrella term do we use for these?
I suspect when it comes to madness, we are unable to distinguish the suffering that stems from the intrinsic nature of the experiences, if you will, and that which stems from how those experiences are framed and managed by society. This creates a profound moral responsibility.
I am humbled to share this article @NatRevMCB 🎊🎊 Kudos to my phenomenal student @AlevBaysoy who put together this comprehensive & impressive review! Kudos to @Zhiliang_Bai, a super talented postdoc and rising star! Thanks a ton to @satijalab for the computational section!!!
how would a drug (which can pass the BBB) interact with this system at the atomic level? nobody knows.
we dig and dig and find out there is more to dig.
Vesicular transport in a bundle of neurons. Made this movie some years ago. Incredible how much material is constantly being moved around in our cells over long distances by tiny (nanometer scale) motor proteins #microscopy, #science, #cells_are_amazing
A quick thread on our @Nature paper on Assembly Theory. https://t.co/R82Nl8U9FM 1/10 Assembly theory provides a new framework to understand selection and evolution that integrates physics and biology. It redefines objects not as particles but by their formation histories.