Dipesh Risal

Life Sciences pun-dit. i like telling stories. stx biologist by training.

[Dipesh Risal @ls_pun_dit]

a new way of thinking about mental conditions

[Justin Garson @justin_garson]

Excellent paper by @JTAuthor arguing most cases of depression are functional responses to circumstances, not dysfunctions - as most cases of pain are functional responses to bodily harm. This is crucial for healing, as it points us outward, toward the world and how we view it.

[Dipesh Risal @ls_pun_dit]

who else here gets their entire news filtered through the posts of others? guilty

[Dipesh Risal @ls_pun_dit]

@OdedRechavi something else to worry about. 5 days per paper *on average* is impossible, I can confidently say, having published seven myself during my previous reincarnation.

[Oded Rechavi @OdedRechavi]

When I read this headline for the first time I read "5 years" not "5 days" and thought "hmmm that actually sounds like a reasonable amount of time to complete a paper"

[Dipesh Risal @ls_pun_dit]

we keep digging only to find out there is more to dig

[Jonathan Sebat @sebatlab]

When critics say “psychiatric genetics hasn’t delivered” what they are really saying is “I have no clue where to start within this complex web of factors that regulate brain development.” Perhaps they were were hoping for a big flashing sign that says “put drug here” 🙄

[Dipesh Risal @ls_pun_dit]

we keep digging and find out there is more to dig

[Itai Yanai @ItaiYanai]

Reading the literature, it seems as though everything is known. But analyzing practically any dataset yourself quickly reminds you how little we can actually explain.

[Dipesh Risal @ls_pun_dit]

@BioMickWatson We keep digging and find out there is more to dig. There is a better way. Look to the "East" for a wholistic approach to medicine, but *without* throwing out logic and the scientific method

#scientific_method

[Dipesh Risal @ls_pun_dit]

yeah, no.

there might be a biotech boom, but really understanding biology especially disease biology is a long way away. we are just scratching the surface and we find that the more we dig, the more there is to dig. we need a paradigm shift in biotech research.

[Ash Jogalekar @curiouswavefn]

I think he's being very overoptimistic here. Unlike the determinism of engineering, biology is vastly more non-linear with feedback loops and unknown complexity. There will be a revolution in biotech, but not necessarily of the engineering kind and not that soon.

[Dipesh Risal @ls_pun_dit]

the more we dig, the more we see that there is to dig. when will we stop?

[Andy Shih @AndyShih_Lab]

It's all connected... In this study, we show that tiny injuries created deep in the brain's capillary bed can contribute broadly to blood flow impairment by constricting upstream supply vessels. https://t.co/D38oMFbIwD

[Dipesh Risal @ls_pun_dit]

waiting for all of them to sprout horns or tails (or whatever else GMOs are supposed to do)

[David R. Liu @davidrliu]

Our lab as well as students in the class I teach this semester enjoyed tasting the first CRISPR-edited salad greens, in which the myrosinase gene that results in the pungency of raw mustard greens (Brassica juncea) has been disabled, yielding a nutrient-dense, tasty, and attractive, salad without the ‘mustard bomb’. Thank you @PairwisePL for providing the samples!
The science behind the greens: https://t.co/KDef1iwGKK
Disclosure: I am a cofounder of Pairwise Plants along with @JKeithJoung and @zhangf.

[Dipesh Risal @ls_pun_dit]

in other words, Zen and the Art of Motorcycle Maintenance. Pirsig said it many years ago.

[Itai Yanai @ItaiYanai]

Daniel Dennett just published "I've Been Thinking"! In it he discusses his process of “tillosophy”: when you realize you're stuck, deliberately switch to a less intellectually demanding activity (like tilling a field on a farm), as this actually helps move the thinking forward.

[Dipesh Risal @ls_pun_dit]

yea, what you said with salt and black pepper

[Rhea 🌊 @rheajgurung]

is there really anything more simple and decadent than a soft boiled egg ✨

[Dipesh Risal @ls_pun_dit]

@phylogenomics wonderful color palette

[Dipesh Risal @ls_pun_dit]

omiscs-ome

[Ewan Birney @ewanbirney]

There is increasing need to talk about multi-dimensional, different molecular measurements of humans and life - germ line genomics, somatic genomics, transcriptomics, proteomics, metabolomics. But we have a comms issue - what umbrella term do we use for these?

[Justin Garson @justin_garson]

I suspect when it comes to madness, we are unable to distinguish the suffering that stems from the intrinsic nature of the experiences, if you will, and that which stems from how those experiences are framed and managed by society. This creates a profound moral responsibility.

[Dipesh Risal @ls_pun_dit]

epi-transcriptome...

one more -ome to join the circus thanks to @RongFan8

we dig and we dig and we find there is more to dig

[Rong Fan @RongFan8]

I am humbled to share this article @NatRevMCB 🎊🎊 Kudos to my phenomenal student @AlevBaysoy who put together this comprehensive & impressive review! Kudos to @Zhiliang_Bai, a super talented postdoc and rising star! Thanks a ton to @satijalab for the computational section!!!

[Dipesh Risal @ls_pun_dit]

looks like a 100uL just by the tip:pipette ratio

[the above is not a tweet]

[Vega Shah @dr_alphalyrae]

no comments

[Dipesh Risal @ls_pun_dit]

flys are overrated. they fly around, eat crap and make more flies. they don't even wiggle wiggle

[Michael 英泉 Eisen @mbeisen]

You know how sometimes people discover million dollar paintings for $10 in a thrift store?

[Dipesh Risal @ls_pun_dit]

unpopular opinion: maybe give out Nobels in the life sciences only AFTER someone makes pills to cure the Big Diseases.... @NobelPrize

[Dipesh Risal @ls_pun_dit]

how would a drug (which can pass the BBB) interact with this system at the atomic level? nobody knows.

we dig and dig and find out there is more to dig.

[Jeffrey van Haren @JeffreyHaren]

Vesicular transport in a bundle of neurons. Made this movie some years ago. Incredible how much material is constantly being moved around in our cells over long distances by tiny (nanometer scale) motor proteins #microscopy, #science, #cells_are_amazing

[Dipesh Risal @ls_pun_dit]

wow, amazing science.

but i just added one more to my ever-increasing list of -omes [background: i believe we dig and dig but we find more to dig so...]

assemblome©

[Prof. Lee Cronin @leecronin]

A quick thread on our @Nature paper on Assembly Theory. https://t.co/R82Nl8U9FM 1/10 Assembly theory provides a new framework to understand selection and evolution that integrates physics and biology. It redefines objects not as particles but by their formation histories.