Lukas Gruber

stealth

[Lukas Gruber @lukasgruber__]

you can think of the World Liberty team what you want, but this was by far the most productive conference with not only industry makers but also policy makers and tradfi institutionals @ mar a lago

will share some of the insights & opinions from policy makers i got in the coming days. happy to be able to talk about @StreetFDN & valuable tokens to these people

[Lukas Gruber @lukasgruber__]

This is a pretty poor take after the HuggingFace incident. Few scenarios:

(a) one misaligned agent with access to the knowledge can immediately consolidate tens of billions of dollars

(b) insider at one of the frontier labs abuses the knowledge for personal gains

(c) payoff could soon become worth revealing it

(d) Using it doesn’t necessarily reveal it, and that's imo the most problematic bad narrative for "sovereign" crypto.

(e) If the first lab expects competitors to discover the same method, using it as soon as possible on e.g. satoshis wallet could be more valuable than keeping it secret

can't even say nothing ever happens because things keep happening in the past month

[Lukas Gruber @lukasgruber__]

@zamdoteth you don't want to know how many stanford students i met this year who raised $3m+ pre-seed in '25 with the pure intent of paying themselves a salary to life-maxx during university

[Lukas Gruber @lukasgruber__]

@0xSigil @a16z @khoslaventures @HummingbirdVC @AnthropicAI @MenloVentures @patrickc @naval @rauchg @polynoamial @Thom_Wolf @Mascobot @tszzl @OfficialLoganK @underdogdotai @ConwayResearch nice congrats

[Lukas Gruber @lukasgruber__]

I have enormous conviction in Agemica’s team and mission.

Proud to help raise $200,000 for cancer and disease research.

I’ve locked my $AGE holdings and committed more of my own capital to the ecosystem because I believe in what we’re building.

The Agemica team is here for the long term, and I believe the biggest chapters are still ahead of us.

[Lukas Gruber @lukasgruber__]

@useKled time to flip grass

[Kled AI @useKled]

This is Kled V3. We've solved data collection for artificial general intelligence.

Any consumer dataset that can exist, can now be collected from physical reality in under 72 hours.

All powered by the largest and most comprehensive data application layer on the planet. (Thread)

[Lukas Gruber @lukasgruber__]

@Armv7lFx the 2s position open delay is pretty insane ngl, there‘s absolutely no edge, pure casinofication of perpetuals.

bullish though, every edge in crypto should be decayed to the house

[Lukas Gruber @lukasgruber__]

@maxmarchione *0.0001 bps

[Lukas Gruber @lukasgruber__]

@katexbt @hack_vc you seriously think hack vc killed a person😭

[Dario Amodei @DarioAmodei]

Today we announced the Claude-led discovery of a molecular machine that we suspect could represent a new gene editing mechanism. Its precise function, biotechnological utility (if any), or level of significance is not yet clear, but at minimum it is work I would have been proud to do as a PhD student. The work was done mostly, though not entirely, by Claude: our life sciences team suggested a broad area of research, Claude read through the literature and a bunch of genome data and discovered something interesting, then Claude proposed experiments to verify the discovery and our team carried them out.

It’s easy to dismiss this as a one-off or curiosity, but we’ve repeatedly seen a pattern where AI performance in new intellectual domains goes from weak to superhuman in a matter of a few years. In 2023 models struggled to do math at the level of an average high-school student. In 2024 they started to do well on math competitions for the best high-schoolers in the country, in 2025 they started to solve minor open problems, in early 2026 more significant open problems, and in late 2026 they are beginning to solve the top few open problems in all of mathematics. We believe AI for biology is on a similar exponential trend.

The main difference between biology and mathematics, of course, is that math can be done purely theoretically, while biology requires experimentation. Some have used this to draw the conclusion that AI’s utility in biology will be limited. We think this is wrong. As we’ve demonstrated today, humans can collaborate with AI to perform the experiments, validate key results in a few weeks and, if necessary, work with the AI to iterate on what they find. Eventually it may even be possible for Claude itself to safely perform the experiments by autonomously controlling lab equipment, with appropriate safeguards in place, but we aren’t doing that today (our lab is also a BSL1/BSL2 facility that doesn't handle materials dangerous to humans).

More broadly, biomedical advancement has many stages — from fundamental biology discoveries, to translational research, to drug discovery, clinical trials, and finally the actual delivery of medicines and health care to patients. We are also interested in these later stages, but even simply accelerating the first stage of fundamental biological discoveries has the potential to speed up and broaden the entire pipeline. Improving our understanding of biology and sharpening biologists’ tools can drive forward all of the later stages, for example by identifying new drug targets, finding new therapeutic modalities, allowing for more precise measurement, and speeding up the experimental loop which itself further accelerates our understanding of biology. This will not in itself speed up clinical trial times, but if it succeeds it could greatly increase the number of promising candidates that go into the pipeline — an increase in throughput even though latency remains.

In Machines of Loving Grace, I wrote about AI’s potential to “cure most diseases in 5-10 years” — a goal that sounds impossible, but one I believe is just barely possible if AI is applied to every stage of the pipeline. The first step is showing that AI can first help with, and then drive, biological discoveries.

Claude’s discovery is the latest in a line of related prior work that goes back decades, beginning with systems like CRISPR, and continuing with discoveries like the bridge recombinase and VIPR in the past few years. Recently, there has been heightened interest in systems based on reverse transcriptase (RT) enzymes, the enzyme underlying the system Claude identified. And most recently, a Stanford team working independently described a novel RT system with an associated non-coding array that is in some ways similar to the one Claude found, though they are distinct systems that evolved independently from each other. I believe that we’re at the very beginning of finding such systems and developing them into powerful tools for biotechnology.

I’m proud of the resources Anthropic has invested in accelerating the public benefits of AI through the life sciences, and we’re aiming both to grow our life sciences team and to work with other scientists to extend this approach to a broad range of problems. If you have a proposal for a research collaboration or are interested in joining our life sciences team, please reach out.

[Agemica @AgemicaCom]

Introducing Agemica.

On our mission to solve aging.

[Lukas Gruber @lukasgruber__]

Excited for this partnership with @AgemicaCom and @RonjonNag.

[Street Foundation @StreetFDN]

Excited to work together with @AgemicaCom on their mission to solve aging.

[Lukas Gruber @lukasgruber__]

@Shaughnessy119 yes ai top is in because we‘re dumping scale ai (dead company since 2023) secondaries on coinbase

[Lukas Gruber @lukasgruber__]

@hhpStreet very interesting

[Lukas Gruber @lukasgruber__]

@the_vc_intern real

The startup opportunity is in making those pieces work together: Investor verification, shareholder records, transfer restrictions, corporate actions and trading.

[Lukas Gruber @lukasgruber__]

@Rileyspnl @cz_binance @StreetFDN won't take a lot more waiting time....

[Lukas Gruber @lukasgruber__]

@mewwts real

[Lukas Gruber @lukasgruber__]

@MEADGod @ponsdotfamily check pm pls

[Lukas Gruber @lukasgruber__]

@heettike tk is an awesome founder, generational opportunity to work with someone insanely talented & driven

shoot him a PM

[Lukas Gruber @lukasgruber__]

@AnoMrsp being pro crypto = being pro the west(ern governments)