Edgar Pinedo-Carpio

Postdoctoral Research Fellow. Functional Genomics, DAGS@ Merck | PhD. in Experimental Medicine@ McGill| CRISPR-based Spatial Genomics

[Rafeeque @rafeequemavoor]

Free scientific illustrations for biologists! 😍

@NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations!

all freely available in the public domain.

Retweet and spread the message!
https://t.co/p1bD1kxO7H

[MRC Laboratory of Medical Sciences (LMS) @MRC_LMS]

FANCI that! New #LMSResearch from @RuedaLab has solved the decades long mystery of how DNA damage by sunlight, alcohol and pollution is identified so it can be repaired.

This discovery opens up opportunities for improved cancer treatments.

https://t.co/2t3b2RZ9je

[Arjun Raj @arjunrajlab]

Excited to launch our cloud-based image analysis platform today at https://t.co/sXb3CPV5B4! Analyze and interact with your data, all in the browser. Follow sign-up instructions to request an account.

[Edgar Pinedo-Carpio @lymphocytePC]

@elonmuskADO Twitter

[Steven Ge @StevenXGe]

How did humans loose our tails?
~25 million years ago, a monkey in Africa had a random mutation due to transposable elements (TEs) - pieces of DNA that can copy themselves in the human genome.

An Alu element was inserted into the intron of the TBXT gene, producing alternative transcripts lacking the 6th exon. This is due to pairing with another Alu element in the other side of the 6th exon.

This mutation is only observed in hominoids without tails: gibbons, gorilla, chimps. Their common ancestors can be traced to that one monkey-like animal 25 million years ago.

Introducing this mutation to mouse results in complete loss of the tail.

Congrats @ItaiYanai
Read this week's cover story of Nature.
https://t.co/J5VHqy9HQJ

[FIFA World Cup @FIFAWorldCup]

Only one team could progress to the next round... 🇯🇵🇸🇳

#BeachSoccerWC

[The Sapieha Lab @psapieha]

We are thrilled to share our study on the role of cellular #senescence in #diabetic macular edema and clinical data for the first #senolytic developed for the eye . Congrats @SerCresGar and @UnityBiotech!
@UMontreal @NatureMedicine @CellSenResearch
https://t.co/8p60afLoko

[Alberto Ciccia @CicciaAlberto]

Excited to share our recent study in @CellCellPress led by @GiuseppeLeuzzi_ on the dual role of the DNA translocase SMARCAL1 in regulating innate immune signaling and the expression of the PD-L1 immune checkpoint factor! https://t.co/TCsq0f0XYo

[Mark Smith Photography @marktakesphoto]

On a scale of 1-10, 10 being perfect, I have to award this eagle with a 12. 😃 If you ever wanted to see a perfect example of an eagle’s ability to fly, grab a fish and eat it in mid air, I think this is it. What would you give this eagle on a scale of 1-10?

[Gaublomme Laboratory @GaublommeL]

Excited to share: "CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue". We applied our novel approach in wonderful collaborations with @CicciaAlberto, @DrEdmondChan, @elhamazizi, and @landau_lab. https://t.co/ucvRawmLdz

[Guido Meijer @guido_meijer]

I was watching Lord of the Rings last night and realized there are many parallels with academia!

A thread 🧵👇

[Edgar Pinedo-Carpio @lymphocytePC]

@soccergoalie67 @SebMarinMD @LoveThePlateau France's tuition fees for international undergrad students: €2,770 Euros per year, €3,770 for postgrad study and €380 Euros per year for a PhD. Non-EU PhD candidates are not subject to new differentiated tuition fees. But QC thinks FR is giving them a preferential rate 🙄

[Josh Wolfe @wolfejosh]

Wow. Wow. Wow.

Incredible powerful message (incredible speech writing)—to those who stumbled on the wrong path and may ruin their future for not knowing the past.

The weight of history

[Manolis Kellis @manoliskellis]

Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity
Paper 1: scRNA + vulnerability + resilience https://t.co/I7cmizyj9C
Paper 2: scATAC + GWAS + Epigenome Erosion https://t.co/bdtlu9bWDr
Paper 3: Microglia States + reprogramming https://t.co/NzEJF1wY3t
Paper 4: DNA damage + gene fusions https://t.co/hIY1tMMhLo
MIT News: https://t.co/oLDuBBb45S
Issue: https://t.co/Mup3orjhcl
News & Views: https://t.co/xQk5mepDqz

[Nature Biotechnology @NatureBiotech]

Genes associated with autism and other neurodevelopmental disorders are identified using CRISPR screening in human forebrain assembloids. #NBThighlight
https://t.co/qfRsPXffQV

[Science Magazine @ScienceMagazine]

Svetlana Mojsov helped discover the hormone GLP-1, which led to the development of blockbuster obesity drugs. Now, she’s fighting for recognition. #LongReads https://t.co/MN5g9lFk6M @NewsfromScience

[Edgar Pinedo-Carpio @lymphocytePC]

@CarlosMendezPhD Thanks Carlos!! You advice was always appreciated 😉

[Edgar Pinedo-Carpio @lymphocytePC]

@DessaptJ Congrats brother, very proud of this story and all the amazing teamwork that led to this publication. I FIRRMly believe that we are going to hear a lot about this novel protein and its partners.

[orthweinlab @orthweinlab1]

We are very excited to share with you the results of great teamwork with @AmelieFT lab! In this study, two graduate students @lymphocytePC and @DessaptJcharacterized the critical role of FIRRM/C1orf112 in the disassembly of RAD51 during DNA repair. https://t.co/N8ytJexUVR

[David R. Liu @davidrliu]

Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. https://t.co/oLp8VN0Iiw
PDF: https://t.co/JoKm9BxW89
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