Bon

Orbiter

[Bon @maxcrow]

@RobertJenrick Isn’t your constituency Newark? Why do you never post about the good of Newark? Why do you try to fuel hatred in other counties? Is this what your Israeli funders are telling you to do? Are you just another greedy pawn in the great game?

[Led By Donkeys @ByDonkeys]

How Musk broke Twitter and helped elect Trump
(Location: Tesla European HQ, Amsterdam)

[FULLDOME UK @FULLDOMEUK]

We’re delighted to share the lineup for this year’s festival! Our team has carefully reviewed numerous entries and is excited to present a diverse selection of pioneering fulldome films.

Festival Dates: 11-12 October 2024
@CULTVRLAB , Cardiff

https://t.co/vp613SzOXV

[Alan Kelly @akellyucc]

Everyone slags Starmer over the family background in tools but in fairness he can assemble a cabinet quickly

[David It Up! @Dave_it_up]

Sources
[1] COVID-19: Long-term effects - Mayo Clinic https://t.co/pfDLI5Ci7y
[2] Elevated circulating monocytes and monocyte activation in COVID ... https://t.co/MrRNyirnsu
[3] SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 ... https://t.co/8ZtCvVw5d2
[4] Long COVID Basics - CDC https://t.co/FIPHXUMEtD
[5] How COVID-19 triggers massive inflammation https://t.co/HLhZ978kit
[6] SARS-CoV-2 Infection Of Monocytes Triggers Inflammation - Forbes https://t.co/M5t4XQYtO6
[7] Long COVID: Long-Term Effects of COVID-19 https://t.co/t0O20NQmKk
[8] Monocytes and Macrophages in COVID-19 - Frontiers https://t.co/Vdrnh4L0bP
[9] Impact of COVID-19 on people's livelihoods, their health and our ... https://t.co/KCHiF7MHW6
[10] FcγR-mediated SARS-CoV-2 infection of monocytes activates ... https://t.co/Xn5I8taspW
[11] Long-term effects of COVID-19 (long COVID) - NHS https://t.co/3mHd4aAxwW
[12] Functional reprogramming of monocytes in patients with acute and ... https://t.co/yMmWo3W1JC
[13] Consequences of COVID-19 and Its Variants - NCBI https://t.co/AwrR7oIpJ4
[14] A virus-specific monocyte inflammatory phenotype is induced by ... https://t.co/Uub19X58mb
[15] Underlying Medical Conditions Associated with Higher Risk ... - CDC https://t.co/dXXXCbKswG
[16] SARS-CoV-2 can infect blood monocytes and trigger inflammation ... https://t.co/WcJISOiAWc
[17] The Implications of COVID-19 for Mental Health and Substance Use https://t.co/MBJ89ZBVVw
[18] Monocytes and Macrophages in COVID-19 - PMC - NCBI https://t.co/ZYgddiNfsZ

[David It Up! @Dave_it_up]

COVID-19 Infecting Blood Monocytes, Oh my!

COVID-19 has profoundly impacted global health, economies, and daily life. The disease can lead to multi-organ complications and long-term health issues, now officially named "Long COVID.". The damage of Long COVID can persist from months to years and include fatigue, shortness of breath, cognitive issues, and organ damage[1][4][7].

The Role of Monocytes in COVID-19

Monocytes are a type of white blood cell that plays a crucial role in the body's immune response. They are part of the innate immune system and are responsible for phagocytosing pathogens and presenting antigens to T cells. In the context of COVID-19, monocytes have been found to be significantly affected by the virus, leading to various immune dysregulations.

Infection and Activation of Monocytes

Research has shown that SARS-CoV-2 can infect blood monocytes, which are then activated to produce inflammatory responses. Approximately 10% of blood monocytes in COVID-19 patients are infected with the virus[3][16]. The infection of monocytes triggers the formation of inflammasomes, which are multiprotein complexes that play a key role in the inflammatory response. This activation leads to a form of cell death known as pyroptosis, which releases pro-inflammatory cytokines and exacerbates inflammation[3][10].

Dysregulation and Long-term Effects

Monocyte dysregulation is not limited to the acute phase of COVID-19. Studies have found that even after the resolution of the initial infection, monocytes in convalescent patients exhibit altered levels and activation states. This dysregulation can last for several months and may contribute to the development of Long COVID symptoms, particularly pulmonary complications[2][12]. Elevated levels of specific monocyte subsets, such as CD14^+CD16^+ monocytes, have been associated with severe COVID-19 and long-term pulmonary issues[2][8].
Consequences of Monocyte Infection
The infection and subsequent activation of monocytes by SARS-CoV-2 have several significant consequences:

1. Hyperinflammation: The activation of inflammasomes in monocytes leads to the release of large amounts of pro-inflammatory cytokines, contributing to the cytokine storm observed in severe COVID-19 cases[3][6]. This hyperinflammatory state can cause extensive tissue damage and multi-organ failure.

2. Immune Dysregulation: The infection of monocytes disrupts their normal function, leading to impaired pathogen recognition and antigen presentation. This can result in an inadequate immune response and prolonged infection[12][18].

3. Long-term Health Issues: Persistent monocyte dysregulation can lead to chronic inflammation and contribute to Long COVID symptoms, including respiratory issues, fatigue, and cognitive impairments[1][4][7].

4. Potential Therapeutic Targets: Understanding the role of monocytes in COVID-19 pathophysiology opens up potential therapeutic avenues. Targeting the pathways involved in monocyte activation and inflammasome formation could help mitigate the severe inflammatory responses and improve patient outcomes[5][10].

The infection of monocytes by SARS-CoV-2 is a critical factor in the pathogenesis of COVID-19. It leads to significant immune dysregulation and contributes to both the acute severity of the disease and the long-term complications experienced by many patients. Continued research into the mechanisms of monocyte infection and activation is essential for developing targeted therapies to treat and prevent the severe consequences of COVID-19.

[NASA Earth @NASAEarth]

The last 12 months have each set record high temperatures for their respective month – an unprecedented streak, @nasagiss scientists say.

The records are part of a long-term warming trend driven by human activities, especially greenhouse gas emissions. https://t.co/93dkAWvBV1

[Bon @maxcrow]

@Stretchedwiener Great idea!

[Scarred for Life @ScarredForLife2]

SEVEN LITTLE MONSTERS (1971): beautiful and macabre Sesame Street short by Maurice Sendak, narrated by Ken Nordine. After reports that kids were 'freaked out' by it, they stopped airing it (but it later became a 1977 Sendak book and 00's kids show)

[Jason Major @JPMajor]

16mm film camera footage showing the descent and landing of the Apollo 11 LM Eagle on July 20, 1969. You can see the boulder field that Neil Armstrong had to avoid by continuing further west, passing over Little West crater and touching down about 60 meters beyond.

[Bon @maxcrow]

@Birduder344 @ProgRockGrandad @primarily_prog It’s the same recording as the anniversary 5.1 remaster that’s on the blue ray.

[ESA Earth Observation @ESA_EO]

Data don't lie:
as reported by @CopernicusECMWF from January to October, the year 2023 was 0.1°C warmer than the ten-month average for 2016, currently the warmest calendar year on record, and 1.43°C warmer than the pre-industrial reference period.

📈Global surface air temp anomalies
📈Daily sea surface temp

Full report for October here: https://t.co/E1wxgR1CvX

[Prism Pipeline @PrismPipeline]

We're excited to announce the release of Prism Pipeline 2.0 🥳

You can download the free version from the website or get a premium plan for additional features and support:
https://t.co/nYqWhRxYyY

You can also download the free version from GitHub:
https://t.co/5z1knH3fPC

[NSC Creative @NSCcreative]

Pink Floyd - The Dark Side of the Moon The Planetarium Experience has won the long form award at the Macon Film Festival '23. Thanks to the Pink Floyd team for the opportunity to create immersive visuals for such a renowned album and our team for bringing it to life on the dome

[Bon @maxcrow]

@kawauso_twi Thank you! We are making a sequel to We are Stars, using the same characters and visiting the most exciting places in the Solar System. The theme is about danger. So, hopefully only a small overlap with your production.

[Bon @maxcrow]

@MoveAI_ I’d like to make some free spooky animations as a halloween gift for planetariums

[Majella McAteer @majellamcateer]

Received many positive feedback on how much the families enjoyed their day out watching the show. Well done to all who involved making this inclusive for all 🙌

[National Space Centre @spacecentre]

🎶 It's almost time for @pinkfloyd's The Dark Side of the Moon to take over our planetarium.

📽️ Fulldome film produced by @NSCcreative, who worked with Aubrey Powell, Pink Floyd's creative director.

🎟️ Get your tickets for this great gig. https://t.co/wbjoKEQyh3

[Bon @maxcrow]

@FULLDOMEUK awesome. I really need that.