Maladaptive trained immunity in viral infections
In this Review, Dmitri Sviridov et al. @GWTweets posit maladaptive trained immunity arises from contextual factors and discuss its contribution to system disease and viral vaccine responses.
https://t.co/KAPNTaEq2Z
A 79 y/o man with an 8-month history of VEXAS, with myelodysplastic syndrome, presented with acute-onset fever, bilateral anterior nodular scleritis, and a pustular skin rash. Exam showed large, widespread, non-follicular pustules
Clinical images in A&R
https://t.co/Y3nXy20Yxd
Captions:
Large, widespread, non-follicular pustules were observed (A and B). Skin biopsies from two separate lesions revealed a dense neutrophilic infiltrate in the superficial dermis containing poorly differentiated neutrophils similar to band neutrophils and prominent leukocytoclasia, with no evidence of vasculitis (C, D, and E)
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
Congrats @PBreillat @TerrierBen @KosmiderO https://t.co/9RFXKXLxht
ICYMI: Chemotaxis as a driver in immune privilege.
O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.
https://t.co/HjHwwf8OO3
Our paper with @ArthurMageau is out in @AjHematology 🗞️
Close monitoring of anti-ADAMTS13 antibodies titer may guide immunomodulation strategies #iTTP 🩸
Thanks to the wonderful team of CNR MAT 🤝🏼 🇫🇷
https://t.co/CVDv7c9sd6
🔍 New study: Cluster analysis identifies 3 distinct clinical patterns among patients with systemic autoimmune diseases & anti-Ku antibodies
🫀 Cardiac involvement is common & evolves differently across clusters—highlighting need for vigilant follow-up
👉https://t.co/OXSC97LXM0
NEW RESEARCH for #LUPUS2025—Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study https://t.co/JuugKrtiWO
Plus, linked Comment https://t.co/Ebihee1Pwv
Chilblains were reported in #SARSCoV2–exposed individuals without PCR- or serologically defined #COVID19. Saidoune, Gilliet, @AhmadYatim_ et al. show that excessive TLR7 responses to SARS-CoV-2 by pDCs are linked to I-IFN–driven chilblain development. https://t.co/v9f3OzBQF6
Five years after the first description by our group and others of SOCS1 insufficiency as a new cause of monogenic immune dysregulatory disorder, we are very pleased to share this international cohort of patients just published in @TheLancetRheum
https://t.co/gMpuMr1z8k
.@Clemence_Dvd et al. @crow_lab suggest that UNC93B1 mutations cause monogenic systemic #lupus erythematosus or chilblain lupus due to differentially enhanced TLR7 and TLR8 signaling. https://t.co/T9bsycia38
📘 In our #Immunology update collection: https://t.co/laek6xwqwp
See our Comment on: Inflammatory plasma protein levels are elevated years before sarcoidosis diagnosis 🇸🇪🇫🇷 thanks to Etienne Villain @NaderYatim @ArthurMageau@RaphaelBorie@nathanpsmad @darragh_duffy and all co-authors
https://t.co/1rBUHovOBB
Nonischemic cardiac involvement in VEXAS syndrome is rare, primarily pericarditis, myocarditis, and heart vasculopathy; these are directly linked with VEXAS’s systemic inflammation. https://t.co/jANipDoBiS @mimrobert @TerrierBen @mekinian2@RimBourguiba1@SophieGeorgin
Le 13-Novembre est gravé dans nos mémoires en lettres de douleur.
Le Bataclan, les terrasses, le Stade de France. Paris, Saint-Denis. La France. Marqués à jamais par l’effroi.
Les victimes, les familles, ceux qui ont tout donné pour préserver la vie, à jamais dans nos cœurs.
Ce soir de 2015 et les jours qui ont suivi, face à l’horreur et à la haine, notre courage a redoublé.
Toujours, nos valeurs et notre unité sont demeurées inébranlables.
Nous n’oublierons jamais.
Merci à la Villa M, au groupe Pasteur Mutualité et leurs mutuelles partenaires de soutenir notre projet MoSAR !!
Merci aussi à l’@institutpasteur et à l’@APHP de rendre ce projet possible !! @darragh_duffy @NaderYatim @KarimSacre @nathanpsmad@RaphaelBorie on avance !!