Marie Robert

Resident in Internal Medicine and Clinical Immunology - MD-PhD @APHP @InstitutPasteur @criu1149

[Journal of Clinical Investigation @jclinicalinvest]

Maladaptive trained immunity in viral infections

In this Review, Dmitri Sviridov et al. @GWTweets posit maladaptive trained immunity arises from contextual factors and discuss its contribution to system disease and viral vaccine responses.

https://t.co/KAPNTaEq2Z

[ACR_Journals @ACR_Journals]

A 79 y/o man with an 8-month history of VEXAS, with myelodysplastic syndrome, presented with acute-onset fever, bilateral anterior nodular scleritis, and a pustular skin rash. Exam showed large, widespread, non-follicular pustules

Clinical images in A&R
https://t.co/Y3nXy20Yxd

Captions:
Large, widespread, non-follicular pustules were observed (A and B). Skin biopsies from two separate lesions revealed a dense neutrophilic infiltrate in the superficial dermis containing poorly differentiated neutrophils similar to band neutrophils and prominent leukocytoclasia, with no evidence of vasculitis (C, D, and E)

[AmericanJournalofHematology @AjHematology]

Anti-ADAMTS13 antibodies trajectory is associated with ADAMTS13 recovery in immune-mediated #TTP
https://t.co/zvLyD8riko #hematology

[Jerome HADJADJ @HadjadjJerome]

Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
Congrats @PBreillat @TerrierBen @KosmiderO https://t.co/9RFXKXLxht

[Journal of Clinical Investigation @jclinicalinvest]

ICYMI: Chemotaxis as a driver in immune privilege.

O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.

https://t.co/HjHwwf8OO3

[Marie Robert @mimrobert]

Our paper with @ArthurMageau is out in @AjHematology 🗞️
Close monitoring of anti-ADAMTS13 antibodies titer may guide immunomodulation strategies #iTTP 🩸
Thanks to the wonderful team of CNR MAT 🤝🏼 🇫🇷
https://t.co/CVDv7c9sd6

[RMD Open @bmj_rmdopen]

🔍 New study: Cluster analysis identifies 3 distinct clinical patterns among patients with systemic autoimmune diseases & anti-Ku antibodies

🫀 Cardiac involvement is common & evolves differently across clusters—highlighting need for vigilant follow-up

👉https://t.co/OXSC97LXM0

[The Lancet Rheumatology @TheLancetRheum]

NEW RESEARCH for #LUPUS2025—Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study https://t.co/JuugKrtiWO

Plus, linked Comment https://t.co/Ebihee1Pwv

[Journal of Experimental Medicine @JExpMed]

Chilblains were reported in #SARSCoV2–exposed individuals without PCR- or serologically defined #COVID19. Saidoune, Gilliet, @AhmadYatim_ et al. show that excessive TLR7 responses to SARS-CoV-2 by pDCs are linked to I-IFN–driven chilblain development. https://t.co/v9f3OzBQF6

[Nature Protocols @NatureProtocols]

#NewNProt: Protocol Extension describing joint spatially resolved epigenomic and transcriptomic profiling on a tissue section using #microfluidic chips https://t.co/Mh21S2uXfV #spatialtranscriptomics #spatialepigenomics see also associated News&Views

[Jerome HADJADJ @HadjadjJerome]

Five years after the first description by our group and others of SOCS1 insufficiency as a new cause of monogenic immune dysregulatory disorder, we are very pleased to share this international cohort of patients just published in @TheLancetRheum
https://t.co/gMpuMr1z8k

[Nick Banovich @NeBanovich]

🙌🙌🙌

https://t.co/fz2wGBOT8V

[Nature Rev Immunol @NatRevImmunol]

Trained immunity in chronic inflammatory diseases and cancer https://t.co/GTjgJDKl1J

[Journal of Experimental Medicine @JExpMed]

.@Clemence_Dvd et al. @crow_lab suggest that UNC93B1 mutations cause monogenic systemic #lupus erythematosus or chilblain lupus due to differentially enhanced TLR7 and TLR8 signaling. https://t.co/T9bsycia38

📘 In our #Immunology update collection: https://t.co/laek6xwqwp

[Marie Robert @mimrobert]

See our Comment on: Inflammatory plasma protein levels are elevated years before sarcoidosis diagnosis 🇸🇪🇫🇷 thanks to Etienne Villain @NaderYatim @ArthurMageau @RaphaelBorie @nathanpsmad @darragh_duffy and all co-authors
https://t.co/1rBUHovOBB

[JAMA Network Open @JAMANetworkOpen]

Nonischemic cardiac involvement in VEXAS syndrome is rare, primarily pericarditis, myocarditis, and heart vasculopathy; these are directly linked with VEXAS’s systemic inflammation. https://t.co/jANipDoBiS @mimrobert @TerrierBen @mekinian2 @RimBourguiba1 @SophieGeorgin

[Marie Robert @mimrobert]

💙🤍♥️

[Emmanuel Macron @EmmanuelMacron]

Le 13-Novembre est gravé dans nos mémoires en lettres de douleur.

Le Bataclan, les terrasses, le Stade de France. Paris, Saint-Denis. La France. Marqués à jamais par l’effroi.

Les victimes, les familles, ceux qui ont tout donné pour préserver la vie, à jamais dans nos cœurs.

Ce soir de 2015 et les jours qui ont suivi, face à l’horreur et à la haine, notre courage a redoublé.

Toujours, nos valeurs et notre unité sont demeurées inébranlables.

Nous n’oublierons jamais.

[Cell Stem Cell @CellStemCell]

Trained immunity in the bone marrow: Hub of autoimmunity https://t.co/n8k11NEGnL

[Marie Robert @mimrobert]

Merci à la Villa M, au groupe Pasteur Mutualité et leurs mutuelles partenaires de soutenir notre projet MoSAR !!
Merci aussi à l’@institutpasteur et à l’@APHP de rendre ce projet possible !! @darragh_duffy @NaderYatim @KarimSacre @nathanpsmad @RaphaelBorie on avance !!