Adam He

Machine learning, RNA transcription, genomics, statistical genetics. Postdoc @ Stanford Genetics

[Anthropic @AnthropicAI]

The US government, citing national security authorities, has issued an export control directive to suspend all access to Fable 5 and Mythos 5 by any foreign national, whether inside or outside the United States, including foreign national Anthropic employees.

The net effect of this order is that we must abruptly disable Fable 5 and Mythos 5 for all our customers to ensure compliance.

Access to all other Claude models is not affected.

We apologize for this disruption to our customers. We believe this is a misunderstanding and are working to restore access as soon as possible.

Read our full statement: https://t.co/bwn0sximKZ

[Nature Biotechnology @NatureBiotech]

A deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency https://t.co/piJGOCOLZw
https://t.co/fk95nlWxte

[antisense. @razoralign]

HoloCell: A Generative Foundation Model for Holistic Cellular Modeling https://t.co/8gBVsBbl8k

[nature @Nature]

Nature research paper: Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

https://t.co/bIQVEcuRgG

[antisense. @razoralign]

CREP: Cis-Regulatory Element Predictor Based on Fine-Tuned Enformer https://t.co/oE1tRAZIBQ

[Jian Yang @jyang1981]

SV-GWAS is highly accessible now! Our new paper in @NatureGenet shows how HiFi long-read assemblies let us repurpose SNP-based GWAS data to impute structural variants (SVs) to interrogate their role in human complex traits and diseases. @WeiyangBai https://t.co/zSB90E3at0

[nature @Nature]

Nature research paper: Distinct genetic architecture in the tails of complex traits

https://t.co/W7ONBMmjtw

[Adam He @missing_a_rib]

@dmitrypenzar To be even more precise, "crazy fast", and it would seem both are true.

[Jason Chin @infoecho]

@mbeisen Maybe we just don’t understand AI enough, I am all sold by this (I can’t take responsibility for AI generated work here, I can’t be as good as AI)

[Peter Koo @pkoo562]

[SAVE THE DATE] MLCB 2026 will be held Nov 16–17 at the New York Genome Center in NYC!

Submission deadline is July 1 AOE
• 8-page full papers: oral or poster, with optional proceedings
• 2-page work-in-progress papers: posters

Spread the word! RT!

https://t.co/BTmQMzLN4d

[Adam He @missing_a_rib]

@anshulkundaje Best case scenario is that they forgot to plot some exons or the tracks are on different genome builds. 😱

[Adam He @missing_a_rib]

@jmschreiber91 @anshulkundaje DeepLIFT/SHAP reports a lot of scary deltas when I've run it at bf16 before, so I mostly stick to tf32 where the deltas look more smol.

[Adam He @missing_a_rib]

@anshulkundaje Wow how did it know I'm from Mumbai and Nigeria??

[UCSC Genome Browser @GenomeBrowser]

Two new variant-impact tracks from Illumina on the UCSC Genome Browser: PrimateAI-3D scores every coding missense variant (hg38/hg19); PromoterAI scores every non-coding substitution near transcription start sites (hg38). See our news for more: https://t.co/FMNe3en9L5

[Nature Biotechnology @NatureBiotech]

An in vivo gain-of-function perturbation sequencing approach enables large-scale mapping of astrocytic transcription factor function in healthy and diseased mice #NBThighlight https://t.co/JIG6ei8sTt

[Emmy Liu @_emliu]

wrote a guide on getting compute grants as a student, something I wish I did more at the beginning of my PhD. It's honestly one of the highest ROI things you can do as a student (we've gotten 100k+ gpu hrs for roughly 2 weeks of work writing).

https://t.co/U15nwau88a

[Hao Yin @HaoYin20]

Harmony2 required only 2.1 GB and 1.3 minutes per million cells, and "scales linearly", and can integrate the full Tahoe-100M dataset & Human Lung Cell Atlas (Hierarchical integration)

vs Harmony scVI ComBat-seq Seurat-RCA LIGER-Quantile Normalization/-Centroid Alignment

@m_hemberg @ilyakorsunsky bioRxiv 2026
https://t.co/3tcRb0RBcn

[Abdul Muntakim Rafi @muntakim_rafi]

was asked how far seq2exp models generalize across species.remembered this amazing work.Enformer predicts accessibility,histone marks across mammals and even birds.But hit a wall at fish,suggesting there's a phylogenetic breakpoint.lots of other cool stuff
https://t.co/PXeFNunJff

[Sasha Gusev @SashaGusevPosts]

Monthly median Received to Accepted time (days) at Nature Genetics