MPI Bioinformatics Toolkit (MPI for Biology)

An integrative platform for protein sequence and structure analysis. Tweets by @Vikram_Alva @MPI_Bio

[MPI Bioinformatics Toolkit (MPI for Biology) @mpitoolkit]

Our paper describing the new Toolkit is out!
https://t.co/1hxY4beQN8

[Vincent Conticello @VincentContice2]

Donor Strand Complementation and Calcium Ion Coordination Drive the Chaperone-free Polymerization of Archaeal Cannulae https://t.co/1NKKP7hFqj

Happy that the preprint is now published. Great collaboration with fantastic colleagues. @conticellolab @EmoryChem

[Alex Bisson @Archaeon_Alex]

This story started 5y ago with my lab. Spearheaded by fearless 1st authors @theopi and Olivia Leland. Theopi is now a PhD student at @BrownUniversity. Olivia is a physics PhD student at @BrandeisU, a self-taught biologist, and made us love soft matter. A (very long) thread (1/24)

[Vikram Alva @Vikram_Alva]

Excited to share our team's discovery on tissue-like multicellularity in archaea under mechanical compression! Led by @theopi, Olivia Leland & @Archaeon_Alex, it rethinks the evolution of multicellularity beyond eukaryotes. @HFSP @MPI_Bio

https://t.co/ONNTYKIiDm

[Alex Bisson @Archaeon_Alex]

New paper online @PNASNews! Great collab with @Vikram_Alva, @PohlschroderLab, @SchmidLab and inspiring team work within the Bisson lab.

PNAS: https://t.co/JQ63AmQ8kB

Preprint: https://t.co/QT9EWXA1Sb

Blurb: https://t.co/QYJnOc2D5J

highlights below (1/4)

[Remus T. Dame @DameLab]

I am very pleased to share our recent study on prokaryotic histone structure and diversity https://t.co/d20OHSG8LS Great work by PhD student @SammyBoterhammy. With @aimeelboyle, @Vikram_Alva, Birte Hernandez Alvarez, Yimin Hu, @MPI_Bio, @LeidenScience

[Leiden Science @LeidenScience]

Some bacteria have proteins much like ours that organise their DNA. Biochemists from @DameLab & the @MPI_Bio reveal this in a new paper. Their work helps us better understand evolution & how bacteria organise their DNA. Read: https://t.co/R0SYshku5y
@Vikram_Alva
@SammyBoterhammy

[Vikram Alva @Vikram_Alva]

Thrilled to share our manuscript on bacterial histone HBb from Bdellovibrio in @NAR_Open! We report DNA-bound HBb structures, showing its DNA bending properties. With Birte Hernandez Alvarez, @DameLab, Yimin Hu, @SammyBoterhammy, @MPI_Bio, @LeidenScience

https://t.co/F0qEpmPyES

[Jonathan Doye @JonathanDoye]

I am excited to share our new preprint on the structure of S-layers. The work is a collaboration between @OxfordChemistry (Ed Johnston and myself) and @buse_isbilir and @TBharat_lab at @MRC_LMB and @Vikram_Alva at @MPI_Bio. 🧵 1/11
https://t.co/SbZqHfjrFc

[Vikram Alva @Vikram_Alva]

Excited to share our new preprint on S-layers! We've modeled ~150 S-layers spanning the prokaryotic tree of life. Great collaboration with Ed Johnston, @JonathanDoye at @OxfordChemistry, @buse_isbilir, @TBharat_lab at @MRC_LMB, and myself at @MPI_Bio.

[Vikram Alva @Vikram_Alva]

Happy to share our review on the versatile and emerging roles of PII-like proteins in cell signaling, coordinating vital metabolic states across life forms. @MPI_Bio

[Vikram Alva @Vikram_Alva]

🔬Excited to share the revised version of our manuscript on the bacterial histone HBb from Bdellovibrio, led by Yimin Hu and @SammyBoterhammy. A fantastic collaboration with Birte Hernandez Alvarez, @DameLab, @HartmannLab.
@MPI_Bio @LeidenScienceEN

https://t.co/TKLc1a6U6P

[Vikram Alva @Vikram_Alva]

🌱 Thrilled to share our latest research on #BrownAlgae sex determination! Led by Susana Coelho, our team has revealed a fascinating connection between the sex determination processes in brown algae and animals. #Evolution @MPI_Bio https://t.co/KafnclGmMF

[Vikram Alva @Vikram_Alva]

Thrilled to share our latest preprint on BiorXiv! A fantastic team effort led by @za_curtis, Pedro Escudeiro, and John Mallon! Check out @Archaeon_Alex's thread for a quick dive into our exciting findings! 🔬

[Alex Bisson @Archaeon_Alex]

We have a new story out at BiorXiv! Amazing work led by @za_curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson).

Great collaboration with @Vikram_Alva (Max Planck) and @pohlschr (UPenn).

A summary of our findings in the thread (1/22)
https://t.co/qGvuQ7mwO1

[derekseveri.bsky.social @DerekSeveri]

For those of you who missed this post last year, I welcome applications until the end of January. This is approximately 50% bench and 50% computation, involving both microbiology and plant work.

[Intelligent Systems @MPI_IS]

We are hiring! Calling all outstanding candidates in the field of intelligent systems to establish up to two new W2 independent #research groups at our institute's #Stuttgart site: #Robotics, Human-Machine Interaction, Robotics for #Healthcare, #AI etc.
https://t.co/KAYjoPZVxz

[Vikram Alva @Vikram_Alva]

Delving deeper, we used DAP-seq to reveal that HBb binds along the entire genomic DNA of B. bacteriovorus without sequence specificity. The wonders of bacterial histones continue to unfold! Dive into our manuscript for more details: 👉 https://t.co/y4XGgZNk5F

[Vikram Alva @Vikram_Alva]

🔬New insights on bacterial histones! 🧬 Our study, led by Yimin Hu & @SammyBoterhammy, shows that in Bdellovibrio bacteriovorus, HBb bends DNA uniquely, differently from eukaryotic & archaeal histones. Great collaboration with Birte Hernandez, @DameLab. @MPIBio @LeidenScienceEN

[Remus T. Dame @DameLab]

Now online our studies on the role of the Bdellovibrio bacteriovorus bacterial histone in chromatin organization https://t.co/tTy0qKKgbH
Great collaboration between @Vikram_Alva, Birte Hernandez and @DameLab spearheaded by Yimin Hu and @SammyBoterhammy. @MPIBio @LeidenScienceEN