Runyu Mao

[Ethan Goddard-Borger @ethangbaus]

A big thanks to @RoySocChem for awarding our team the 2024 Chemistry Biology Interface Horizon Prize. It is wonderful recognition for a productive collaboration with @sjwill99, @ProfG101 and so many others. #RSCPrizes #glycotime

https://t.co/pGsDujXqTv

[Runyu Mao @mryzjjs]

@ethangbaus Cool!

[Ethan Goddard-Borger @ethangbaus]

How does nature catalyse C–C bond formation between protein and mannose?

The answer can be found in @nchembio today: https://t.co/a7adBPRb9q

This was a wonderful collaboration with @lab_locher, @Joel_S_Bloch, and many others. Congrats and thanks to all involved!

#glycotime

[Nature Chemical Biology @nchembio]

Work by @Joel_S_Bloch, @lab_locher, @ethangbaus reveals the structure, mode of peptide recognition, and catalytic mechanism of the eukaryotic C-mannosyltransferase DPY19. Open access: https://t.co/GpW3A0Pm6o #glycotime

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

[Ethan Goddard-Borger @ethangbaus]

The role of tryptophan C-mannosylation in the malaria parasite lifecycle - now out in @NatureComms. It was great to be involved in this multidisciplinary effort led by @drboddey. @WEHI_research #glycotime #malaria https://t.co/rELYAKN13K

[John Burn-Murdoch @jburnmurdoch]

NEW: for the first time in the pandemic, a Covid infection now carries less mortality risk than a flu infection in England, the result of widespread immunity and the emergence of a less virulent variant in Omicron.

Our story: https://t.co/BnFWG7xwaS

[Michael Worobey @MichaelWorobey]

We have just released two preprints on the origin of SARS-CoV-2:

1. "The Huanan market was the epicenter of SARS-CoV-2 emergence"
https://t.co/OAVNoWdezs

[Scott Bagley @BagPhos]

I’m so excited to share our #PfizerChemistry collaboration with the @uwyoongroup @TehshikYoon @UWMadisonChem on photochem/Cu(II) mediated cross-coupling – no photocatalyst needed!
https://t.co/0ejoOYq2gq
1/n

[pieterstreicher @pieterstreicher]

1 of 6:

Gauteng #Omicron update:

Cases in Gauteng are likely to peak between 12 and 20 December.

The growthrate in 7 day average cases is slowing down consistently. It was 5% per day in the last day, down from 28% per day 12 days ago.

[Cees Dekker @cees_dekker]

Today we publish a paper in @ScienceMagazine that expands nanopore readings to the proteome:
a nanopore-based scanner to read off PROTEINS at the single-molecule level! 🤩

Awesome experiments by postdoc Henry Brinkerhoff of our #CDlab, with MD simulations of @aksimentievLab

1/x

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The 2021 #NobelPrize in Chemistry has been awarded to Benjamin List and David W.C. MacMillan “for the development of asymmetric organocatalysis.”

[Ethan Goddard-Borger @ethangbaus]

Our latest work on tryptophan C-mannosylation is out today in @J_A_C_S. It describes photoreductive cross-coupling methods for the late-stage C-mannosylation of peptides. Congratulations to Runyu @mryzjjs and the rest of the team. 1/4
https://t.co/KhDLfkiHuG

[Michael Roy @dr_mroy]

Please RT: Are you passionate about targeted protein degradation? Apply + join our new team @WEHI_research: 2x chemists PhDs (https://t.co/QgT5un0tC7), Cell Biologist/Proteomics PhD (https://t.co/BKzLuySLbg), Structural Biologist RA (https://t.co/KhruHPH91E). Closing 26 Feb 2021.

[Nature Portfolio @NaturePortfolio]

Computer, which reaction should I run next? Research in Nature shows that Bayesian optimisation can be used to help synthetic chemists optimise their reactions with greater efficiency and consistency. https://t.co/qYFmByLnpb

[Ethan Goddard-Borger @ethangbaus]

My lab’s latest work on tryptophan C-mannosylation was just published in @nchembio.
https://t.co/5ZxI6dCtWC

Congrats to @DrAlanJohn and all else involved!

The main points to take home from this work are as follows... (1/7)

[WEHI (Walter and Eliza Hall Institute) @WEHI_research]

New @NatureComms research led by @ethangbaus has revealed how the body regulates mucus viscosity. The findings could help to advance airway-clearing treatments for people with chronic respiratory conditions.

https://t.co/Cgf2eJMffy

[Runyu Mao @mryzjjs]

@ethangbaus PAINs？

[Corey Stephenson @crjsteph]

The group was super excited by the news this morning. Congratulations to Anthony Allen on being awarded a @NSFGRFP fellowship. His mechanistic investigations have dramatically expanded the scope and understanding of our aminoarylation reaction (https://t.co/g2Hqdvz4Ja)

[David R. Liu @davidrliu]

Screen of 3,000 FDA- and IND-approved drugs for the ability to block #SARSCoV or #COVID19 #SARSCoV2 infectivity in cultured Vero cells identified Niclosamide (IC50=0.28 uM, minimal tox) and Ciclesonide (IC50=4.3 uM) as promising hits for further study. https://t.co/oADP6ZBsJb