Our big story on the importance of "stripy" T cells in antigen response, which started as a MSc Thesis 6 years ago, has finally made its way out in @ScienceMagazine! 🤩
Massive congrats to @BenHale95 & thanks to all collaborators particularly @LabOxenius & @blutspendesrk 🥰
Two exciting studies out in @Nature show that high tumor PGE2 limits IL-2 sensing and antitumor function in TIL. Disrupting this axis can potently enhance antitumor responses. Nice work @CoukosGeorge@JBoettcherLab and teams!
https://t.co/6HTcYVQdhB
https://t.co/4ZV79YNVek
Now online in @CD_AACR: CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T cell Pool https://t.co/T2T093pCfY @KapteinPaulien@Thommen_ds@NKI_nl
Don't miss the 1st International Symposium of Institut Curie, bringing together researchers from all walks of science such as @mt_christin, postdoctoral researcher at @NKI_nl, who will give a talk on intratumoral heterogeneity in luminal #breastcancer.
➡️ https://t.co/J0hPhOGyyX
📆 Les 15, 16 et 17 mai prochains, l'Institut Curie vous donne rendez-vous au cœur de Paris dans un cadre historique et prestigieux, pour la 1ère édition de son Symposium International "From Basic Science to Cancer Research".
Pour en savoir plus ↘️
https://t.co/AOEPbod7rH
Really happy to see this beautiful study out, unveiling TEs distinct expression patterns across the T-cell exhaustion axis and upon ICB. Glad to have contributed to this work! Congrats to all authors and specially to @pe_bonte, Christel Goudot and Sebastian Amigorena 🎉
Really happy to share my PhD work recently published in @SciImmunology in which we study the impact of T cell exhaustion on transposable elements (TEs) and explore their potential as biomarkers in #cancer and #immunotherapy
https://t.co/pvSEuOxrgj
#ScienceImmunologyResearch 🧵⬇️
CD8+ T cells in the cancer-immunity cycle: CD8+ T cells are “end effectors” of cancer immunity. Wherry, Kaech, Giles, & Globig review the current understanding of CD8+ T cell differentiation and function in cancer, discussing recent advances within a four-signal framework that incorporates T cell metabolism and the impact of the tumor microenvironment. https://t.co/CJrJSwlySe
I’m delighted to share our @NatureCancer paper by Anne Kraemer et al. https://t.co/QETM3Lrwso Our objective was to investigate whether there are substantial differences in the antigenic landscape presented in tumors that are T cell inflamed versus those that are non-inflamed.
Seventy years on from the discovery of the structure of DNA, controversy still surrounds two central points: how much credit Rosalind Franklin deserved, and the degree to which she was denied it https://t.co/nSHwbJ2fxA
A 2021 @institut_curie@psl_univ study involving patients with lung #cancer defined the origins and organization of tumor-infiltrating killer T cells.
📄: https://t.co/bOkWC4feha
Excited to share that our work on regional T cell clonal responses to immune checkpoint blockade is out now! Very grateful to @AndrewChowMDPhD, Matthew Hellmann, @Satpathology, and all other co-authors for this wonderful collaboration.
Check it out here!
https://t.co/SJQmfG8iFn
Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature https://t.co/jPfmX2Ilrq