neuro aging

Researcher on longevity promoting interventions. Purposefully vague.

[neuro aging @neuroaging]

@Aging_Scientist @metapredict not the OP, but in my view

1 - voicing concerns about misallocation of resources can be constructive

2 - you're mixing life expectancy at birth with adult lifespan and mixing global avgs with best-case countries. the jump from 30s mainly reflects fewer kids dying young

[neuro aging @neuroaging]

@JerichoSionNat @wethebots_ @ydeigin @agingdoc1 It's possible only if you have unlimited resources and scientists willing to work on a paper that will be published after they're long dead, as one of a 100 authors. Science is merciless, it's not feasible and I'm telling you objective constraints as someone who works in aging

[neuro aging @neuroaging]

@ydeigin @felixchin1 Please note that both of these use AAVs, which differs greatly from transgenic models where, one would assume, these benefits would be observed first due to more robust expression

(there are tissue-specific reprogramming strains)

[neuro aging @neuroaging]

@ydeigin @AlexanderMWolf7 It needs to be cell-specific. Tissues are heterogeneous and various cells (even of the same type) respond differently to reprogramming either due to stochasticity, delivery variance, microenvironment etc.

There are people working on this

[neuro aging @neuroaging]

@wethebots_ @JerichoSionNat @ydeigin @agingdoc1 It has been done in flies, and the number of genes that change is in the hundreds/thousands. The same experiment in mice is not feasible due to the number of generations needed - who's gonna fund (and carry out) a 100+ year experiment?

[neuro aging @neuroaging]

@CharlesMBrenner @ydeigin Maybe the experiments are ongoing, manuscripts are in prep, or there are IP reasons why you (or the general public) hasn't seen this data yet ;)

[neuro aging @neuroaging]

@bdmarotta @bryan_johnson I wish he does, then he'd need to show all the data.

So it won't happen. If someone publishes false and misleading statements about your business, you take them to court. But not Bryan. Ask yourself why.

[neuro aging @neuroaging]

@DerKeerlen @bryan_johnson @R89Capital It's funny how he pretends he doesn't know what survivorship bias while saying NYT published false and misleading statements. If anyome wasn't sure if he was scamming before, now you have your answer

[neuro aging @neuroaging]

@bryan_johnson @R89Capital Aren't you now publishing false and misleading statements?

People who have side effects will not complete the study. The allegation is that only 300 out of 1700 people completed the study. Stop trying to weasel your way out of this and give a direct answer to what's being asked.

[neuro aging @neuroaging]

@NUSMedicine "Professor" Boris Djordjevic? Are you sure about that? At which university? As far as I know, they don't even hold a doctorate

Also, 199 "Research institute" sounds a bit like Andrew Tate's Hustlers "University"

[neuro aging @neuroaging]

@ydeigin @sebastian_gero I am aware of the limitations, organ failures and teratomas in reprogramming. And we need safety. But targeting the subset of cells that we know are detrimental on their own is the extreme. So no, I don't think we have robust data on reprogramming extending lifespan (yet). (5/5)

[neuro aging @neuroaging]

@ydeigin @sebastian_gero Don't get me wrong, this is interesting work. But to really prove the power of reprogramming in aging, we need to go beyond just targeting cells that we know cause problems when they accumulate with age. That would be a true breakthrough in aging research. (4/5)

[neuro aging @neuroaging]

@MaxUnfried Agreed, those are two separate questions. But if something can extend maximum mouse lifespan by 100%, then it's unlikely that it wouldn't have *any* effect on human lifespan

It doesn't have to yield the same 100%, and it likely wouldn't. Still more valuable than a 3 year delay

[neuro aging @neuroaging]

@ydeigin They sometimes trigger me too. Similar to economic reasons in papers when some argue what is the societal burden of life with disability and how much profits could be made and money saved if only people weren't as sick. Those people should be in politics or economics, not aging

[neuro aging @neuroaging]

@JulesBass6 @NathanCycle @LSTCI_Lab This ain't it, chief

[neuro aging @neuroaging]

@davidasinclair No, they wouldn't. To solve aging you need the tech required for the stuff you mentioned, and a lot lot more. What a bad take, even for you.