MD student @SchillerLab @LMU_Muenchen | MSc Bioinformatics @EdinburghUni - interested in single cell omics | mountaineering enthusiast | Views are my own
Very excited to share that our paper (and my MD thesis work) on perturbational single cell genomics to study early stage pulmonary fibrosis is now published in Science Translational Medicine!!!
👉 https://t.co/yUf6EWnGn4
@ScienceTM
Great teamwork with co-first @schniering_j
‼️ Landmark #lungcancer research published today in Cell
Scientists at the Francis Crick Institute and UCL have discovered a 14-protein blood signature that predicts lung cancer more than 5 years before diagnosis, works in never-smokers, and could identify who benefits from prevention treatment.
People with high levels of these proteins were the ones who actually benefited from a drug to damp that inflammation down, cutting their lung cancer risk nearly in half.
This could finally give us something lung cancer has never had: a way to prevent it in the people most at risk.
https://t.co/SaZwBHnxvZ
#LCSM
1/n
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
https://t.co/ggvtGE3NMA
@NeBanovich Adding this cool preprint from the labs @IPFdoc and @alisonejohn to this collection of IPF spatial trancriptomics papers:
https://t.co/RAT6rgwsXk
Two exciting spatial transcriptomics papers mapping the altered cellular landscape in Pulmonary Fibrosis
in @NatureBiotech and @ScienceAdvances - they have been around as preprints for some time, but just stumbled across them today. #CureIPF
Details below👇
Just stumbled across this super impressive preprint from @NeBanovich's Lab - which must not be missing from this collection - Particularly impressed by how they provide a spatially-resolved model of disease progression over time - definitely worth a read!
https://t.co/SSkmEFZjvB
Exciting paper in @NatureCVR: venous ECs branch and differentiate into capillary ECs to regenerate the alveolar gas exchange unit following lung injury - but NOT in fibrotic (KRT5+) or AT1 depleted regions - some food for thought:
https://t.co/EBDhf67EPj
Last day on the wards as a med student! Now, time to focus on finals so I can return as a physician soon :)
Grateful for all I’ve learned during my elective year in Zürich & Basel 🙏
Plus, I got to share some magic moments with old and new friends high up in the alps! 🇨🇭🏔️
Super excited to share our latest work on immune-epithelial interactions in lung fibrosis post COVID-19! This would not be possible without the invaluable help from all the co-authors and our collaborators - Thank you!
Read below for more info!
https://t.co/bzwfVQ3BKI (1/11)