Nilimesh Das (নীলিমেশ দাস)

Physical Chemist
Postdoc in Boston Children's Hospital
Phd in IIT Kanpur
Interest: Biophysics, Bengali literature, food, mohun bagan, Barcelona, Indian Cricket

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

Happy to share my first author paper.

RNA-binding proteins are thought to enhance transcription by forming condensates.
We show that nascent RNA recruits FUS to boost polymerase loading
and accelerate elongation by preventing R-loops, without requiring condensates

[Nilimesh Das @NilimeshDa6026]

Thrilled to share our paper in @NatureComms

RNA-binding proteins can enhance transcription largely independently of condensation

Nascent RNA recruits FUS to transcription site, boosting RNAP loading and preventing R-loops to enhance elongation.
https://t.co/6KC1knQYkR

[The Nogales Lab @NogalesLab]

How does human NuA4/TIP60 recognize and modify nucleosomes? Our work reveals cooperative recognition involving the acidic patch and linker DNA and uncovers an interaction between the Tudor domain and catalytic core that regulates HAT activity.
Preprint: https://t.co/h91vtCpXFr

[Alberto Ciccia @CicciaAlberto]

Excited to share that our map of the genetic interaction network of the DNA Damage Response is out in @NatureBiotech! Led by Sam Hayward, @vaitsiankova and @tlmdz_.
https://t.co/hIV5BLcJuQ

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

How RNA methylation reshape condensates?

It binds FUS more strongly and is associated with larger, more stable condensates.

A small chemical modification with potentially important consequences for the organization of RNA–protein assemblies.
https://t.co/CEWOGevEBO

[Helen Miller @Miller_HelenL]

1/ Are you interested in macromolecular crowding? Then you should check this out:
https://t.co/Mv1pWHKFnI
Why is this important? Well, small molecules tend to diffuse around in cells to get where they need to be, so if there are a lot more obstacles (crowders) that might change

[Jim Haseloff @jimhaseloff]

Macromolecular crowding used to control spatial organization of gene expression in cell-sized vesicles - DNA plasmids and mRNA become localised at the inner surface of vesicles while translation machinery remain uniformly distributed
(https://t.co/M8Ack0apej)

[ZhuLab@NUSChem @zhu_ruyi]

Thrilled to share another piece on DNA catalysis @angew_chem @ResearchFoS. We harness substrates-binding induced crowdedness in DNA pocket for diverse asymmetric 3-component rxns, many of which have not been realized before. Check it out: https://t.co/aJjurhCY9H

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

Polyethylene
Glycol Crowding Enhances Protease-Mediated
Albuminolysis with Distinct Surface Tension Dynamics https://t.co/cps9yH4MgI

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

Rare conformational states may be invisible—but their exchange leaves fingerprints.
CEST NMR across many magnetic field resolves these hidden states to construct the folding path

https://t.co/ygEE4hUnFm

[Subhabrata Maiti @Subhachem]

Our latest @ACS_Langmuir by @adityajoshi112 @Shikha3342 @NandhaEttikkan @ladidakalana85 from @DCS_IISERMOHALI @IiserMohali 🙏 @dbtindia fr funding.
Polyethylene Glycol Crowding Enhances Protease-Mediated
Albuminolysis with Distinct Surface Tension Dynamics https://t.co/bRnIKU8ztr

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

FCS reveals an U-shaped ligand–G4 affinity on crowder size.

Viscous drag suppresses association at first, but larger PEGs generate depletion effects that accelerate ligand capture.

A nice example of competing physics inside crowded environments.

[Sobhan Sen @SenSobhan]

We are happy to share our new findings on how molecular crowding plays a critical role on the Ligand binding to G-quadruplex DNA through the interplay of viscosity and depletion-interaction! Thanks to SRRB (ANRF) for funding support.
@ANRF
https://t.co/meFF4RQ9T2

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

Allosteric regulation of enzymatic catalysis by molecular crowding:

Molecular crowding increases enzymatic activity if the rate-limiting step is formation of the enzyme-substrate complex.

It decreases the activity if the this step is product release.

https://t.co/BtBeNcdrYo

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

Macromolecular crowding effects in the Arrhenius-like and non-Arrhenius temperature regimes of human platelet isoform of phosphofructokinase-1 (PFKP).

PFKP maintains temperature robustness of catalytic activity by soft Interactions, & not crowder size. https://t.co/iPCtAZiLgy

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

Tau aggregation inside condensates is different?

Inside it, Tau enters a distinct kinetic regime: nucleation accelerates, aggregation becomes weakly dependent on total protein concentration, and the resulting fibrils adopt different structures.

https://t.co/aDtx7rUhqO

[Biophysical Journal @BiophysJ]

#OPENACCESS: Predicting water at the protein interface in cryo-EM structures from MD-excess chemical potential. Qinfang Sun, Sriram Aiyer, Avik Biswas, Allan Haldane, Sompriya Chatterjee, Nobuyuki Matubayasi, Dmitry Lyumkis, and Ronald M. Levy. https://t.co/O5Or8rIOUi

[Roshan Rai @RoshanKrRaii]

Breaking : Shekhar Suman comes out in support of Sonam Wangchuk on his show Shekhar Tonite.

This is the most powerful 1 minute you will watch today 🔥

This takes courage and spine, he has become even more brutal after ED Raid on his show’s producer.

Must watch, Must Share

[Sonam Wangchuk @Wangchuk66]

TOO WEAK TO SAY ANYTHING
Amidst all pain this little girl brought a smile on my face.

[Appie Culé @appiecule]

Zlatan Ibrahimović: 🗣️🚨💣

“Today, more than ever, I’m convinced that the campaign after the Argentina vs. Egypt game wasn’t against Argentina—it was aimed specifically at Messi.

“Today we saw a clear handball in the build-up to Mbappé’s goal against Bono. The goal should have been disallowed, yet it stood and completely changed the course of the game. Still, we didn’t see the same outrage or the usual accusations.

“Where are the people who kept claiming Messi had FIFA’s full support and that everything was rigged in his favor? They’ve completely disappeared. Why? Because Messi wasn’t on the pitch.

“For them, it was never about refereeing or fairness—it was always about Messi. Their problem has always been Messi, not Argentina or any other national team.

“Cristiano Ronaldo’s fans are extremely emotional and simply don’t like Messi.”

[Arindam Ghosh @ArindamPhysics]

We need to adapt quickly to the inevitable. Is the capability to effectively use chatGPT or other platforms equivalent to scientific reasoning and innovation that we expect in faculties or students to possess? The line is thin.
https://t.co/kmOGB5h21k

[Nilimesh Das (নীলিমেশ দাস) @nilimeshda]

Correlating picosecond electron transfer and confined water dynamics in Prussian Blue using electrochemical two-dimensional infrared spectroscopy | PNAS https://t.co/pEahZpgm2D