Noble Kumar

PostDoctoral Fellow, Investigating the role of mitochondria in NAFLD and metabolic syndrome

[Noble Kumar @nobletalari]

@UCPPNDept @UCincyMedicine @GradCollegeUC Congratulations Georgios

[Silvi Rouskin @silvirouskin]

As I’ve said multiple times , postdoc is the worst job you can have with a PhD in these times. I try hard to soften this blow for anyone in my lab and it barely scratches the surface..

[Noble Kumar @nobletalari]

@cohenlaboratory @ChihHsuanHsu1 @UNC_SOM Congratulations

[Noble Kumar @nobletalari]

@OlzmannLab @ASBMB Congratulations James Olzmann.

[Noble Kumar @nobletalari]

Excited to share equal first author paper published in @JMCCardiology
Full article link: https://t.co/Ssp15qbrB1
Huge thanks to @KarthicK_PhD , @MattamUsho14047 and @kdrosato

[Karthick Chella-Krishnan, PhD @KarthicK_PhD]

6/ Huge thanks to the amazing team @nobletalari, @MattamUsho14047, Afra, Brook & collaborators! @UCPPNDept @UCincyMedicine @UCResearch @UCCOM_undergrad
Read the full story: https://t.co/EA3QpkA28N
#OpenAccess #ScienceTwitter #MASH #LiverResearch

[Karthick Chella-Krishnan, PhD @KarthicK_PhD]

5/ Why this matters:
Understanding these mitochondrial dynamics offers new insights into how hepatic energy metabolism adapts (or maladapts) in MASH.
Could this open doors to novel therapeutic strategies?

[Karthick Chella-Krishnan, PhD @KarthicK_PhD]

4/ Morphological changes:

Early MASH: PDMs became larger & more elongated.
Advanced MASH: CMs became smaller & fragmented.
👉 This compartmentalization hints at mitochondrial specialization during metabolic stress.

[Karthick Chella-Krishnan, PhD @KarthicK_PhD]

3/ Key findings:

PDMs = bioenergetic powerhouses, with higher pyruvate oxidation, TCA flux & oxidative phosphorylation protein complexes.
CMs = shifted towards fatty acid oxidation, reflecting metabolic adaptation.
Distinct mitochondrial functions drive MASH progression!

[Karthick Chella-Krishnan, PhD @KarthicK_PhD]

2/ What did we investigate?
We examined cytoplasmic mitochondria (CM) and peridroplet mitochondria (PDM) in a diet-induced MASH mouse model.
As MASH progressed, we observed an inverse relationship between these two mitochondrial populations!

[Karthick Chella-Krishnan, PhD @KarthicK_PhD]

1/ New paper alert!
Excited to share our latest work on hepatic mitochondrial subpopulations and their distinct roles in MASH progression!
👉 Read here: https://t.co/EA3QpkA28N
#LiverResearch #Mitochondria #Metabolism #MASH #MASLD

[Noble Kumar @nobletalari]

we characterized the importance of hepatic PDM and CM, found that their content, dynamics, and bioenergetic capacities differentially altered from steatosis to fibrosis progression. Huge thanks to @MattamUsho14047, our PI @KarthicK_PhD  and the entire K lab team

[Noble Kumar @nobletalari]

Excited to see my another first author publication on hepatic mitochondrial subpopulations (Peridroplet mitochondria (PDM) and Cytoplasmic mitochondria (CM) @commBio. https://t.co/pqq6y41Yg9

[Noble Kumar @nobletalari]

@Mottillo_Lab Congratulations Emilio Mottillo

[Karthick Chella-Krishnan, PhD @KarthicK_PhD]

The K lab had an amazing time at the 38th Annual Meeting of the Ohio Physiological Society (OPS)! 🎉 We presented posters and delivered oral talks. Huge congrats to @nobletalari for securing one of the top 5 Blitz Talk awards! 🏆

[Martin Picard @MitoPsychoBio]

One of the most important issues of our time - particularly critical in the US

[Karthick Chella-Krishnan, PhD @KarthicK_PhD]

So excited to announce the publication of our research in @iScience_CP. Kudos to our postdocs, Noble Kumar Talari and Ushodaya Mattam, and our undergrads, Irene Sotomayor-Rodriguez and Afra Rahman. @UCPharmSysPhys @UCincyMedicine @MedSciMenon
https://t.co/xFSI6ynZmJ

[Marc Liesa @marcliesa]

It is out! Here we describe a new method to isolate peridroplet mitochondria (PDM) from white adipose tissue (WAT), revealing unique functional characteristics in WAT PDM determined by lipid droplet size. https://t.co/2GfQ85e4ln

[Noble Kumar @nobletalari]

@KarthicK_PhD @nih_nhlbi @UCPharmSysPhys @UCincyMedicine @UCResearch Congratulations Karthick…

[Noble Kumar @nobletalari]

Happy to share our paper out in @NatureComms, in which we developed a method to isolate lipid droplet associated mitochondria from liver and showed it is bioenergetically different from cytosolic mitochondria population
https://t.co/16Vt1aVITa