As I’ve said multiple times , postdoc is the worst job you can have with a PhD in these times. I try hard to soften this blow for anyone in my lab and it barely scratches the surface..
5/ Why this matters:
Understanding these mitochondrial dynamics offers new insights into how hepatic energy metabolism adapts (or maladapts) in MASH.
Could this open doors to novel therapeutic strategies?
4/ Morphological changes:
Early MASH: PDMs became larger & more elongated.
Advanced MASH: CMs became smaller & fragmented.
👉 This compartmentalization hints at mitochondrial specialization during metabolic stress.
2/ What did we investigate?
We examined cytoplasmic mitochondria (CM) and peridroplet mitochondria (PDM) in a diet-induced MASH mouse model.
As MASH progressed, we observed an inverse relationship between these two mitochondrial populations!
1/ New paper alert!
Excited to share our latest work on hepatic mitochondrial subpopulations and their distinct roles in MASH progression!
👉 Read here: https://t.co/EA3QpkA28N
#LiverResearch#Mitochondria#Metabolism#MASH#MASLD
we characterized the importance of hepatic PDM and CM, found that their content, dynamics, and bioenergetic capacities differentially altered from steatosis to fibrosis progression. Huge thanks to @MattamUsho14047, our PI @KarthicK_PhD and the entire K lab team
Excited to see my another first author publication on hepatic mitochondrial subpopulations (Peridroplet mitochondria (PDM) and Cytoplasmic mitochondria (CM) @commBio. https://t.co/pqq6y41Yg9
The K lab had an amazing time at the 38th Annual Meeting of the Ohio Physiological Society (OPS)! 🎉 We presented posters and delivered oral talks. Huge congrats to @nobletalari for securing one of the top 5 Blitz Talk awards! 🏆
So excited to announce the publication of our research in @iScience_CP. Kudos to our postdocs, Noble Kumar Talari and Ushodaya Mattam, and our undergrads, Irene Sotomayor-Rodriguez and Afra Rahman. @UCPharmSysPhys @UCincyMedicine@MedSciMenon
https://t.co/xFSI6ynZmJ
It is out! Here we describe a new method to isolate peridroplet mitochondria (PDM) from white adipose tissue (WAT), revealing unique functional characteristics in WAT PDM determined by lipid droplet size. https://t.co/2GfQ85e4ln
Happy to share our paper out in @NatureComms, in which we developed a method to isolate lipid droplet associated mitochondria from liver and showed it is bioenergetically different from cytosolic mitochondria population
https://t.co/16Vt1aVITa