Our new Nature study, lead by @yuexing identifies a brief early-life window when skin dendritic cells sense common allergens and trigger inflammation right in the skin without migrating to lymph nodes. We define this in-situ activation state as peripheral immune inducer (pii)DC, and show it emerges because of a still-maturing HPA axis and low systemic glucocorticoids. #Naiklab
👉Key takeaways:
1. Early-life immunity plays by different rules. During this window, innate responses to allergens in skin are heighted.
2. Hormones shape immunity in real time. Developmental neuroendocrine states profoundly tune how the immune system reacts, and can set the stage for inflammatory disease.
Thanks our incredible collaborators @niroanandalab@EmmaGuttman@kamalkhanna@Teresalu@Amandalund and others. Our funders @NIAIDNews @NIH@DermalCell@SinaiImmunol@MSHSDerm
https://t.co/Ipqicx4TDo
You should be so lucky to have people throughout your research career that you can openly bounce ideas to and from - especially if they complement your strengths in your areas of weakness - it is a rare and precious gift.
Looking for a new scientific adventure? 🌟 Assistant Professor (non-tenure) position available in the @DrShrutiNaik lab at @IcahnMountSinai — explore the frontiers of tissue biology in a collaborative, supportive environment. 🧬https://t.co/uAn8zHfSwy
Congrats to superstar @Asma_Farhat2 for being selected as a Simons Postdoctoral fellow to study how inflammation impacts sensory development and function in the Naik lab and the Allen Discovery Center. @SimonsFdn@SinaiImmunol@SinaiBrain
https://t.co/2zOmvK8VZ8
Interested in Inflammatory Memory? Want to learn more about a seminal paper that redefined our understanding of immunology? Check out @DrShrutiNaik and I’s Pillars of Immunology article on Foster, Hargreaves, and Medzhitov’s landmark 2007 Nature study
https://t.co/NInrEhWZdV
A new Yale study shows for the first time that immune-system T cells are present in the brain, sent by the gut to a region that regulates hunger and thirst — a finding about T-cell physiology “that changes everything,” says one researcher: https://t.co/qkfBY46mWh #Yale
Thrilled to share the results of our 8-year-long expedition into the Wild, the city of #NYC , the wild west of #LosAngelesCA , and more—in search of the roots of gut fungal commensalism! 🧵https://t.co/P4vv7Ll9dp
Comment l Stefan Jordan and colleagues from the C3R Wildling HeaD consortium share their experience designing a facility for safe and ethical research with Wildling mice @ChariteBerlin@Jordan_LoMMI@SRosshart@DiefenbachLab
Link 👉 https://t.co/rOUjAL1cDV
Today we report Evo, a generalist foundation model for biology, on the cover of @ScienceMagazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.
Over the moon to be named among the #50ScientistsThatInspire across diverse fields by @CellCellPress!
A heartfelt thank you to my former and current lab members, mentors, collaborators, and friends—you are my daily inspiration!
https://t.co/NnQszWxgIu