Ojore Oka

Research focuses on how proteins fold in the Endoplasmic Reticulum (ER) and mechanisms that cause cell stress and how cells adapt under stress conditions.

[Ojore Oka @ojoreoka]

Our paper on the #UPR transducer, ATF6, is published today in #PNAS. We highlight redox-dependent dimerisation of ATF6 as key regulatory element. Many thanks @BulleidNeil, @Saxy_Scientist, and members of @BulleidNeil Lab. 🙏🏾 @wellcometrust for funding.

https://t.co/YobCOy8WAV

[Avezov lab @AvezovL]

Congrats team!

[Science Magazine @ScienceMagazine]

Plant cells undergo incomplete division and remain connected. This image illustrates two daughter cells linked by strands of endoplasmic reticulum spanning plasmodesmata—tiny bridges for intercellular communication.

New findings in Science reveal that the endoplasmic reticulum holds these bridges open during cell division; without it, plasmodesmata close, addressing a long-standing question about how to combine cell division and communication. https://t.co/N38POIt9tk

[bioRxiv Cancer Bio @biorxiv_cancer]

IRE1-dependent GOLIM4 expression controls protein secretion to modulate glioblastoma cell adhesion and migration https://t.co/soqn4gCUdf #biorxiv_cancer

[UK Dementia Research Institute @UKDRI]

Image 5 of 5: AstrocytER

The endoplasmic reticulum (ER), a network of membranes through which proteins and other molecules move, is stained within astrocytes, the star shaped supporting brain cells.

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[UK Dementia Research Institute @UKDRI]

Image 4 of 5: Amyloid Precursor Protein (APP) - an intracellular journey

APP produces the toxic amyloid beta protein that forms amyloid plaques in Alzheimer's disease. Researchers found that APP's location in the cell is important for how much amyloid is produced.

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[UK Dementia Research Institute @UKDRI]

Image 3 of 5: Super Nova

Astrocytes and Microglia eating up amyloid plaques to fight against the build up and damage caused by misfolded amyloid protein.

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[UK Dementia Research Institute @UKDRI]

Image 2 of 5: Microglia Pioneers

Microglia usually help maintain brain health, but scientists believe they may contribute to the development of Alzheimer's. Here, human microglia (green) grown on a thin slice of mouse brain interact with mouse neurons (red).

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[UK Dementia Research Institute @UKDRI]

Image 1 of 5: The First Responders

Microglia (red and cyan) respond to amyloid plaque (yellow), one of the hallmarks of Alzheimer’s. Microglia are specialised cells that can take on different roles depending on where and how they are needed.

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[Avezov lab @AvezovL]

🔔@CecileCrapart talking at #EMBOer24 about her PhD work on how ER structure dictates its function as a Ca2+ delivering device
covered in https://t.co/mbM153ULCe and https://t.co/gsfDCeZHHX

[Martin Turner @MartT_babraham]

I hated writing—until I learned there’s a science to it | Science | AAAS https://t.co/DhhqsfVEBu

[Verena Kohler @_VerenaKohler]

Ribosomes hibernate on mitochondria during cellular stress https://t.co/wqyUezlYb5

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

[University of Glasgow @UofGlasgow]

We are delighted to once again be named in the world’s top 100 universities in the @timeshighered World University Rankings!

More: https://t.co/J3SkmPZ75j

#THEUniRankings @THEworldunirank

[Biochemical Society @BiochemSoc]

Final call for Scientific Outreach Grant applications! With different funding levels available, don't miss out on this chance to take your molecular biosciences activities to a new and broader audience. Deadline 9 October! https://t.co/cfPSCbCatM

[Avezov lab @AvezovL]

Check this out, nanopores used to look at how a chaperone works, can potentially explain how HSP70/BiP can disaggregate proteins

[Avezov lab @AvezovL]

📰 The updated version of our paper on ER fluidics is out in @eLife

https://t.co/kYB8W08r86

[American Society for Cell Biology @ASCBiology]

MBoC Call for Papers: Special Issue on Protein Quality Control
Submit an article by October 31 to be considered by lead editors:

@LizMillerCU, @MRC_LMB and @Guillou76, @NTUsg

Learn more and submit:https://t.co/HOIAG153Y1

[Journal of Cell Biology @JCellBiol]

ER–plasma membrane contact sites deliver ER lipids and proteins for rapid cell surface expansion, say Madison Smith, Lincoln Gay, and Markus Babst @UofUBiology: https://t.co/DVpCv2AgfN

#Membrane #lipid #Trafficking #Biochemistry #ER_literature

[maurizio molinari @MolinariLab]

Pre-Ai, hand drawn schematics by Ari Helenius published many years ago. Up there, Ari tells us how enveloped viruses enter our cells. Down below, Ari discovers how our cells check the quality of the proteome. Seminal discoveries. Happy 80th birthday Ari.

[Tom Van Agtmael @TomVanAgtmael]

Paper Alert!
Our new work shows collagen IV variants act by collagen IV deficiency, hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease, a major cause of #stroke & #dementia @eBioMedicine @TheLancet @UofGSCMH
https://t.co/x6BRIGBTPD
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