Steve Mount

Steve Mount, Univ. of Maryland.
Interested in gene structure and function, especially pre-mRNA splicing.

[Steve Mount @ongenetics]

@Ronaldofp_ @RepArrington @RepBrecheen @michaelcburgess @RepBuddyCarter The cuts to NIH DO NOT align with America First, if America First means continuing to lead in biomedical research.

[Steve Mount @ongenetics]

RFK Jr. is apparently going to tell Congress today that HHS doesn't need much money.
The cuts have damaged important science. If he says it's all waste and duplication he's either lying or doesn't know his job.
@RepArrington @RepBrecheen @michaelcburgess @RepBuddyCarter

[Steve Mount @ongenetics]

@Ronaldofp_ @RepArrington @RepBrecheen @michaelcburgess @RepBuddyCarter That's what he says, but his actions say that he doesn't think America can afford to be healthy any more.

[Steve Mount @ongenetics]

I loved the TAGC (The Allied Genetics Conferences).
This is really too bad.
@GeneticsGSA

[Steve Mount @ongenetics]

It comes down to the new algorithm. It shows you more of whatever you engage in. The trick is to not engage (not even pause scrolling) with content that you don't want to see a lot more of.
Another thing I do is bookmark in my browser specific people and go directly to their feed.

[David J Glass MD @davidjglassMD]

RNAseq is commonly performed. We compared N=30 wild-type Bl6 mice to an N=30 heterozygotic knockout with a phenotype, and then downsized. We found you need at least an N= 8-12 to avoid a >50% false positive rate. A 2nd line confirmed the finding.

https://t.co/wwKRUcdKmH

[Intermittent Fasting @IFdiet]

Fitbit users are unanimously opposed to removing the browser interface. Many of us feel strongly about it.
https://t.co/BMPMoxoJ3M
The claim that data and features of the dashboard are available in the app is a lie.
Why did they do this? It makes no sense.
#Fitbit is failing.

[Steve Mount @ongenetics]

Rosaceae (berries, stone fruits, apples, and more) has amazing diversity in fruit development.
@BerryLab_UMD has vast omics data that captures much of this variation.
Now, Muzi Li has put it on a nice database.
https://t.co/aD6J4jPxhR
https://t.co/dX85LHl4O5
Glad to have helped.

[Burge Lab @daSpliceIsRight]

Want to understand how splicing decisions are actually made in the cell based on pre-mRNA sequence? PhD student Kayla McCue has been hard at work modelling just that, & we're very excited to announce that now you can read about it in her new preprint! https://t.co/mU2rbjWhjo

[Steve Mount @ongenetics]

You and @DrJennyLord did a great job putting this together!

[Diana Baralle @ProfDBaralle]

Predicting the impact of rare variants on RNA splicing in CAGI6. New paper from us ⁦@CAGInews⁩ #CAGI6 thank you ⁦@DrJennyLord⁩ ⁦@Carolinaj215⁩ ⁦@HtooW⁩ ⁦@ongenetics⁩ ⁦@pedjagogue⁩ https://t.co/7DxVuSuIaQ

[Diana Baralle @ProfDBaralle]

Predicting the impact of rare variants on RNA splicing in CAGI6. New paper from us ⁦@CAGInews⁩ #CAGI6 thank you ⁦@DrJennyLord⁩ ⁦@Carolinaj215⁩ ⁦@HtooW⁩ ⁦@ongenetics⁩ ⁦@pedjagogue⁩ https://t.co/7DxVuSuIaQ

[Steve Mount @ongenetics]

@PetrovADmitri @NKWhiteman The vasoconstrictive properties of nicotine can lead to stroke, but it's definitely better smoking.

[Steve Mount @ongenetics]

Splicing variation shapes mammalian complex traits.
"more sVariants were called than eVariants, and ... multi-tissue sVariants alone explained a similarly large proportion (66%) of heritability to eVariants and sVariants jointly (69.2%)."
Also - many trans sVariants!

[Alejandro Montenegro @aemonten]

OBITUARY

Michael Ashburner (1942–2023)

https://t.co/uEHCW42p6o

[Steve Mount @ongenetics]

I'm starting as one of 23 Associate editors in this new section.

[Frontiers - Bioinformatics and Systems Biology @FrontBioinf]

It's our pleasure to announce a new section, #RNA Bioinformatics, in Frontiers in Bioinformatics, led by Prof. Shuhui Song of the Beijing Institute of Genomics, Chinese Academy of Sciences.

This section is now open for submissions

Discover more: https://t.co/f1QZQiV3J5

[Steve Mount @ongenetics]

Join ISMB/ECCB 2023 in Lyon, France, or virtually July 23-27!

I'm not going to make it this year, but ISMB is always a great conference.

Let's shape the future of our field together! https://t.co/4SVYlFFuGn

#ISMBECCB2023 #ComputationalBiology #Bioinformatics #Conference

[Steve Mount @ongenetics]

This is a nice story about genetic analysis leading to a cure. STAT4 variants contribute to disabling pansclerotic morphea, and it looks like JAK inhibitors are a potential treatment.
I've been hearing about it from @brynjmatt for a while now.
https://t.co/mThDjC8QGu

[Steve Mount @ongenetics]

Another very original insight from @Mayr_Christine!
"a novel mode of protein activity regulation"

[Christine Mayr @Mayr_Christine]

New preprint from us!

mRNAs act as chaperones for IDRs.

mRNAs often bind to IDRs. This changes their conformational ensembles to drive protein complex assembly, and controls protein activity.

Thank you @VickyLuo0223!

https://t.co/0LeTA2bjXv

[Steve Mount @ongenetics]

I'm looking at https://t.co/4lzNULmXfT.
You can also sign up for Post.
https://t.co/xHzIfzg2D2

[Steve Mount @ongenetics]

@aemonten Yes.