Amit Kumar Singh, PhD

Immunologist | Postdoc at HIV Cure Research Center, Ghent University Immunology | Immunotherapy | Host-Pathogen Interaction | Nanotechnology #Athiest

[Justin Eyquem @j_eyquem]

I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo.
A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models.

https://t.co/t3pyjHyGWS

a 🧵

[Global Immunotalks @globalimmuno]

Looking forward to our next #globalimmuno talk this Wednesday, October 1st, at 9am PST, noon EST, 4pm GMT by Dr. Galit Alter.

Title: “Dissecting the antibody-OME to understand human disease”
ZOOM LINK: https://t.co/NLHvXAmaNq
LIVE ON YOUTUBE: https://t.co/oeHYAkS4wt

[Wasim Jaffer @WasimJaffer14]

Series drawn but India take the Anderson-Tendulkar Trophy on boundary count @MichaelVaughan 😜 #ENGvIND

[ParisSG INFOS @Paris_sginfos]

🔴✨ Luis Enrique ✨🔵

[Trends in Microbiology @TrendsMicrobiol]

Advances in host-directed therapy for tuberculosis and HIV coinfection: enhancing immune responses https://t.co/3cowP6fVlY

[Meru @MeruOnX]

Shashi Tharoor should be made India’s international spokesperson ASAP!

[NanoMedicines Innovation Network @NMIN_NCE]

ONLINE SEMINAR: Engineering Synthetic Nanocarriers for Precision Therapy with @ProfScottBME @UVA, Feb 21, 2025

More info: https://t.co/EDNz3xLY04

[Waggoner Lab @LabWaggoner]

Review @NatRevImmunol @SilvestriDM @DeannaKulpa
Immune-mediated strategies to solving the HIV reservoir problem
https://t.co/uBoyZT0ge4

[Journal of Experimental Medicine @JExpMed]

Lee, Benoist et al. @harvardmed profiled all immunologic cell types by RNAseq after systemic exposure to IL1β, IL6, and TNFα, revealing highly redundant cytokine network, with intertwined effects between disparate #cytokines and cell types. https://t.co/jaYfnSVCmH
#Inflammation

[BowTiedBiotech 🧪🔬🧬 @BowTiedBiotech]

1/ THREAD: Where do mRNA vaccines go after injection?

Lipid nanoparticles (LNPs) are the workhorses of mRNA vaccines, but how do they move through the body?

New PET-CT imaging in rhesus macaques gives us answers. 🧵👇

[Amit Kumar Singh, PhD @only_aks]

Excited to share that I have joined Dr. Smith's
@lab_nie lab at @MSUIQ @michiganstateu as a Postdoc in #NanoImmunotherapy! Thrilled to contribute to innovative research tackling cancer and chronic diseases! 🔬🧑‍🔬

[Prof. Nikolai Slavov @slavov_n]

Why does cancer incidence increase with age?

Is it the accumulation of mutations?
Is it declining immune system?
Is it other factors?

This PNAS article emphasizes the role of immune system decline over mutation accumulation.

1/2

[Waggoner Lab @LabWaggoner]

BACH2 regulates T cell lineage states to overcome dysfunction driven by tonic CAR signaling
https://t.co/RgFyPnrTlT
@NathanSinghLab

[Nanoscale journal family @nanoscale_rsc]

How do you get to the mitochondria of a specific cancer cell type? A dual targeted nanoparticle offers such a navigation strategy.
@dharlab @SylvesterCancer @umiamimedicine

Read Nanoscale's inside front cover article by Shanta Dhar et al. here 👇:
https://t.co/82hViRRJ1K

[Nicholas Fabiano, MD @NTFabiano]

The irony

[Waggoner Lab @LabWaggoner]

Review
Tissue-resident immune cells: from defining characteristics to roles in diseases
https://t.co/7c3PRPE5Wq

[Waggoner Lab @LabWaggoner]

Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies
@NatureComms
https://t.co/iFgw2OifDP

[Amit Kumar Singh, PhD @only_aks]

@lab_nie Congratulations to Yapei Zhang! Excited to read the review and be part of such a vibrant team soon!

[David Usharauli @3DiMMUNE]

'Surprisingly, CD8+ T cells with identical T cell receptors exhibit wide variation in avidities, suggesting an additional level of regulation of T cell activity.'

This indicates that we cannot predict a priori which T cells are most protective against tumors.

#immunology

[Nick Norwitz MD PhD @nicknorwitz]

🧬💥What if I told you that social stress doesn’t just mess with your head—it damages your DNA and biologically ages you? (link at the end)

🧵1/9) That’s not hyperbole; it’s hard science from new data published in @NatureAging

If you’re like me—juggling a life full of psychological stress—you might be wondering: How can I fight back?

Let’s break down the data...

(I'll tease: this thread also includes a little honest opinionated "revealer" about @hubermanlab)