I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo.
A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models.
https://t.co/t3pyjHyGWS
a 🧵
Looking forward to our next #globalimmuno talk this Wednesday, October 1st, at 9am PST, noon EST, 4pm GMT by Dr. Galit Alter.
Title: “Dissecting the antibody-OME to understand human disease”
ZOOM LINK: https://t.co/NLHvXAmaNq
LIVE ON YOUTUBE: https://t.co/oeHYAkS4wt
Lee, Benoist et al. @harvardmed profiled all immunologic cell types by RNAseq after systemic exposure to IL1β, IL6, and TNFα, revealing highly redundant cytokine network, with intertwined effects between disparate #cytokines and cell types. https://t.co/jaYfnSVCmH
#Inflammation
1/ THREAD: Where do mRNA vaccines go after injection?
Lipid nanoparticles (LNPs) are the workhorses of mRNA vaccines, but how do they move through the body?
New PET-CT imaging in rhesus macaques gives us answers. 🧵👇
Excited to share that I have joined Dr. Smith's
@lab_nie lab at @MSUIQ@michiganstateu as a Postdoc in #NanoImmunotherapy! Thrilled to contribute to innovative research tackling cancer and chronic diseases! 🔬🧑🔬
Why does cancer incidence increase with age?
Is it the accumulation of mutations?
Is it declining immune system?
Is it other factors?
This PNAS article emphasizes the role of immune system decline over mutation accumulation.
1/2
How do you get to the mitochondria of a specific cancer cell type? A dual targeted nanoparticle offers such a navigation strategy.
@dharlab@SylvesterCancer@umiamimedicine
Read Nanoscale's inside front cover article by Shanta Dhar et al. here 👇:
https://t.co/82hViRRJ1K
'Surprisingly, CD8+ T cells with identical T cell receptors exhibit wide variation in avidities, suggesting an additional level of regulation of T cell activity.'
This indicates that we cannot predict a priori which T cells are most protective against tumors.
#immunology
🧬💥What if I told you that social stress doesn’t just mess with your head—it damages your DNA and biologically ages you? (link at the end)
🧵1/9) That’s not hyperbole; it’s hard science from new data published in @NatureAging
If you’re like me—juggling a life full of psychological stress—you might be wondering: How can I fight back?
Let’s break down the data...
(I'll tease: this thread also includes a little honest opinionated "revealer" about @hubermanlab)