Patrick link

Husband. Father. Veteran. Biomedical engineering PhD. Postdoc studying pulmonary fibrosis. He/Him. Views are mine.

[APS Publications @APSPublications]

Congratulations to @AJPLung March #APSselect winners Betageri, @NCaporarello et al. for “The matricellular protein CCN3 supports lung endothelial homeostasis and function”.

https://t.co/f3cXm68brV

(pictured: Dr. Nunzia Caporarello)

@P_a_link @aj_haak @dtschump1 @MayoClinic

[AJP-Lung Cellular and Molecular Physiology @AJPLung]

🏅Congratulations to Dr. Nunzia Caporarello and coauthors for their #APSselect article “The matricellular protein CCN3 supports lung endothelial homeostasis and function”

Read more: https://t.co/sA64i1kxjJ

@NCaporarello @MayoClinic @budomtweets

[American Physiological Society @APSPhysiology]

CCN3 protein plays an important role in lung endothelial function and could lead to a targeted treatment for fibrosis: https://t.co/YEXwGA2HG1 via @AJPLung. Pictured: author @NCaporarello. #APSselect

[AJP-Lung Cellular and Molecular Physiology @AJPLung]

Authors led by @NCaporarello demonstrate that the matricellular protein CCN3, a regulator of lung #endothelial function, may represent a therapeutic target to facilitate #vascular repair and promote resolution of #PulmonaryFibrosis:

https://t.co/k6AWFUdXc1

@dtschump1 @P_a_link

[Nunzia Caporarello @NCaporarello]

Happy to share that our latest manuscript focused on the role of the matricellular protein CCN3 in supporting lung endothelial homeostasis and function is now out! Thanks to all the coauthors @P_a_link @aj_haak @dtschump1 for the great support! Happy reading 🫁

[APS Publications @APSPublications]

The #matricellular protein CCN3 supports #lung endothelial homeostasis and function (Betageri, @P_a_link, @aj_haak, @dtschump1, @NCaporarello et al. @MayoClinic) - just accepted in @AJPLung

https://t.co/26CY9ey6jK

#lunghomeostasis #pulmonaryfibrosis #articlesinpress

[AJP-Lung Cellular and Molecular Physiology @AJPLung]

🏅Congratulations to Dr. Andrew J. Haak and colleagues from @MayoClinic and @BUMedicine for their #APSselect article “Pim-1 Kinase is a Positive Feedback Regulator of the Senescent Lung Fibroblast Inflammatory Secretome”

https://t.co/hDUI5Q3GnY

@aj_haak

[Nunzia Caporarello @NCaporarello]

Happy to announce that our latest paper reporting the impact of aging on pulmonary vasculature and fibrosis is now out on @NatureComms! Thanks to all the co-authors for the great support! Enjoy the reading 🫁
https://t.co/sdRh5NZ89j
#aging #vasculature #lung #fibrosis

[Patrick link @P_a_link]

@DanAbebayehu @ASCBiology Congrats Dan!

[Joel Boerckel @jboerckel]

This paper is a fabulous demonstration of the combinatorial and compensatory functions of YAP and TAZ. It also gorgeously illustrates the diversity of YAP/TAZ-mediated cytoskeletal feedback across cell types.

Great work @P_a_link, @dtschump1, et al.!

[AJP-Lung Cellular and Molecular Physiology @AJPLung]

Control of #fibroblast contractile programs by #YAP and #TAZ reported in a new #ResearchArticle by Dr. Patrick Adam Link @P_a_link (c), @dtschump1 (r) & colleagues at @MayoClinic pictured here with EiC @RoryMorty (l): https://t.co/9FyFdNvFcI
#IPF #IdiopathicPulmonaryFibrosis

[APS Publications @APSPublications]

Combined control of the fibroblast contractile program by YAP and TAZ - new in @AJPLung

https://t.co/yKle5AEBHt

#Fibroblast #articlesinpress

[Patrick link @P_a_link]

It is my first, first-author publication in the @dtschump1 lab with co-authors Kyoung Choi, @AnaDiazEspinosa, @dakota_jones2, Ashley Gao, @aj_haak and of course @dtschump1.

[Patrick link @P_a_link]

Very pleased to present my newest work which has been published in @ajplung. We show that YAP and TAZ together regulate a focused gene program in fibroblasts that is essential to contractile function. 
https://t.co/mrurwIwmY2.

[Daniel Tschumperlin @dtschump1]

Our latest work, linking dopamine receptor activation to fibroblast inactivation: GPCR‐mediated YAP/TAZ inactivation in fibroblasts via EPAC1/2, RAP2C, and MAP4K7 https://t.co/vry3cD1gSP

[Patrick link @P_a_link]

Our team, @SHWeinbergLab, @beccaheise , and myself, investigated mitosis and Rho GTPase mechanics to suggest that middle-stalk cells undergoing mitosis can disrupt the GTPase cycling of developing vessels.

[Patrick link @P_a_link]

Does functional angiogenesis require a predetermined mitotic order? Our article in @SpringerNature #bmmb asks this question. Check it out: https://t.co/wP8TKl7TWb

[Journal of Cell Biology @JCellBiol]

In efforts to understand the role of epigenetic events in establishing mechanical memory, @dakota_jones2, @dtschump1 and colleagues identify a novel role of ZNF416 in mechano-activation of fibroblast gene programs and functions central to tissue fibrosis. https://t.co/RsQE5L76uP

[Naftali Kaminski @KaminskiMed]

Really cool: combination of #RNAseq of freshly sorted fibroblasts & hypothesis testing in cultured #IPF fibroblasts offers path toward identification of novel regulators of lung fibroblast deactivation, maybe fibrosis resolution #CureIPF https://t.co/RkWtGbke0q

[Daniel Tschumperlin @dtschump1]

I cannot think of a more important time for a meeting on lung development, injury and repair:
https://t.co/Pxb9k2EffM