Panpan Zhang

Postdoc in @CedricFeschotte lab. Code Connoisseur, TE enthusiast, eccDNA and 3D genomes.

[Edward Chuong @edchuong]

I’m excited to share our latest study led by
@GiuliaPasquesi out today in @CellPressNews , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵

[Panpan Zhang @panpan_ird]

@AbiramiSoundir1 CONGRATULATIONS 🥂

[Panpan Zhang @panpan_ird]

Amazing lab retreat 😉. I LOVE the TE community and everyone I've met through #CSHLTE24. Thanks to everyone for all the knowledge/brainstorming/collaborative advice ❤️ 🥰

[Cedric🧬➰🧬Feschotte @CedricFeschotte]

Feschotte Lab richly represented at #cshlTE24 Special shout out to @TE_penthouse for bussing the gang 🚐💕 #proudPI

[Panpan Zhang @panpan_ird]

@AbiramiSoundir1 What?! So many of you are there 😭😭😂

[Panpan Zhang @panpan_ird]

Pity that I didn’t join #ICTE2024 this time, but my PIs from graduate @MANGOLAB1 and postdoc @CedricFeschotte met there! 🎉

[Emilie Aubin @milie_aubin]

Nice talk of Marie Mirouze about eccDNA of TEs with @MANGOLAB1 @sophie_lanciano @panpan_ird @AbiramiSoundir1
#ICTE2024

[Panpan Zhang @panpan_ird]

Welcome 2rd year grad student Cedric 😂😂😂😂—-so funny to see different scenarios of my PI acting out: from humiliation to confidence.

[Science Magazine @ScienceMagazine]

Human telomerase threatens genome integrity by adding telomeres to broken chromosomes and is held in check by ATR kinase signaling.

Learn more in Science ⬇️
📄: https://t.co/OgPfniWBsZ
#SciencePerspective: https://t.co/fBAljiyebU

[Itai Yanai @ItaiYanai]

How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. https://t.co/0ZR8aH23PJ @BoXia7

[Panpan Zhang @panpan_ird]

@CedricFeschotte spicy Doritos works🌶️ 🌶️ 🌶️🤪🤪🤪

[Panpan Zhang @panpan_ird]

@aconga7 @PLOSGenetics Congrats Adrian!

[Panpan Zhang @panpan_ird]

🧬 Amazing follow-up on the Arc gene story! Knowing Arc is derived from a retrotransposon, retaining the gag function to create VLPs for intercellular communication. But what regulates the capsid release? And the role of Arc extracellular vesicle? Check it out #ArcGene #VLP #GAG

[Jason Shepherd @JasonSynaptic]

New preprint 🚨 from the lab! Another paper years in the making from @AliciaRavens and Kaelan Sullivan (not on twitter). TDLR: we describe a new form of intercellular synaptic plasticity! It involves Arc and another cool protein IRSp53. 🧵/1 https://t.co/SbaY06nCAk

[Guillaume Bourque @guilbourque]

We all take repeat annotation in the human genome for granted but are we sure it's correct?

In a 🚨new paper 🚨 from the lab, @xunchen85 shows that up to 30% of primate ERVs/LTRs instances are mis-annotated.

[Panpan Zhang @panpan_ird]

Join us for the #TransposonFest 🔥🎃

[Cedric🧬➰🧬Feschotte @CedricFeschotte]

#TransposonFest at @cornell is this Friday! 🧬➰🧬

Join us if you’re around to celebrate the darkest corners of the genome! 🎃

Symposium with 🔥 lineup will showcase some of the exciting work on TEs on our campus + guest of honor @SueWessler for McClintock Lecture @4pm💥

[Simona Cristea @simocristea]

coming from Jonathan, this must be a wonderful resource for understanding all the details on how population genetics actually works

[Panpan Zhang @panpan_ird]

Incredible story 🌟 Truncated isoform of IFN receptor by Exonized Alu that highly expressed in many cell types: IFN receptor decoy. Can’t be more excited to learn about it!

[Edward Chuong @edchuong]

Excited to share our latest preprint, led by @GiuliaPasquesi , on transposons and interferon signaling! 👇 for a 🧵 on cryptic splice variants, decoy receptors, and viruses (1/N)

[Panpan Zhang @panpan_ird]

@CedricFeschotte @CancerGrand Yeah!!!!

[Panpan Zhang @panpan_ird]

@SharonShle @CedricFeschotte @KeystoneSymp @arburga @panpanzhang Certainly, the realm of TE in tandem array is an under-explored area that holds significant potential. Link of TE expansion pathologies is intriguing.

[Panpan Zhang @panpan_ird]

In general, by sequencing both the eccDNAs and genomes of Arabidopsis epigenetic plants we detected a high eccDNA load associated with genome instability. We speculate that the abundance of eccDNA in ddm1 mutant combinations triggers alternative DNA repair pathways to SVs. 6/n

[Panpan Zhang @panpan_ird]

Finally my graduate work gets out after long process! In this study, we employed our lab's Mobilome-seq/eccDNA-seq methodology to delve into eccDNAs originating from transposable elements within epigenetic plant models. #eccDNA #TEs

[MANGO LAB @MANGOLAB1]

On #eccDNAs, SVs, epigenetic mutants and hot spot of instability at R genes, using #Nanopore. Feedback welcome! 😊https://t.co/fMzq9ntu7m

[Panpan Zhang @panpan_ird]

Unexpectedly, beyond chimeric or truncated TE insertions linked to eccDNA we found large SVs in hypomethylated plants. We detected large tandem duplications (〜55kb) and small deletions in single plants of ddm1 and ddm1/polIV, complexifying the landscape of genomic variation. 5/n