Parham Lab

@StanfordMed Studying the biology, genetics and evolution of the Major Histocompatability Complex (MHC) and other immune molecules.

[Parham Lab @ParhamLab]

Amazing paper by Dr Emily Wroblewski on Malaria-driven adaptation of MHC class I in wild bonobo populations - read it here! https://t.co/WAbBZkBByt

[Alex Cocker @Alex_Cocker89]

Very excited to say our paper exploring CD56neg NK cells has been published! Through a combination of meta-analysis, and both CyTOF and scRNAseq datasets, we investigate this unique population of NK cells linked to HIV-1 and other chronic virus infections https://t.co/fR6fgSZ4Z3

[Billy Palmer @BillyHPalmer]

New paper with @PN0rmski, Gabriel Santpere, @ArcadiNavarro, and @MarcoTelford. Does peptide-specific immune recognition shape herpesvirus protein diversity?
https://t.co/bGyDXbc2Qa

[The Journal of Immunology @J_Immunol]

#JI_TopRead: From researchers @stanfordimmuno @ParhamLab @PN0rmski @HLAB8 | Following Transplantation for Acute Myelogenous #Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01 #ReadTheJI https://t.co/aG74VARJFR

[Parham Lab @ParhamLab]

Our latest release: HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity. @DjaoudZ. https://t.co/XLh7NGgXbg

[Parham Lab @ParhamLab]

Our latest release from @DjaoudZ 'Dimorphism in the TCRγ-chain repertoire defines 2 types of human immunity to Epstein-Barr virus' https://t.co/mhHNr3PgS0

[Dan Davis @dandavis101]

Here’s our new paper — On genetic diversity in the human immune system — five years of research, led by postdoc @pippa_kennedy, and many collaborators. In @scisignal https://t.co/Mum7h0SgZG

[Pippa Kennedy @pippa_kennedy]

Natural Killer cell research in @scisignal ? Well isn’t that just a perfect Xmas present!

[Parham Lab @ParhamLab]

Enhancing NK cell missing self responses with in vitro education by KIR3DL1. Our latest paper out now in @LSAjournal https://t.co/61eVpkM5fe

[Nature Immunology @NatImmunol]

Altfeld and colleagues identify the NK cell receptor NKp44 as directly interacting with the class II HLA-DP in a partially peptide-dependent manner and with functional consequences for NK cell activity https://t.co/hK4eT0QcLC

[Malcolm Sim @mjwsim]

Report from the Eleventh Killer Immunoglobulin-like Receptor (KIR) Workshop: novel insights on KIR polymorphism, ligand recognition, expression and f... - PubMed - NCBI

Hoping to attend the next one in 2020, hosted by ⁦@PN0rmski⁩ https://t.co/5UlK43tJwq

[Parham Lab @ParhamLab]

Our new perspective on the exciting research from @mjwsim and others, an encouraging step for identifying orphan KIR ligands and a role for NK cells in defense against bacterial infection.

[NK cell Biology @NKcellBiology]

A natural killer cell receptor takes sharp aim at the world of bacteria. https://t.co/JkZKJ4sXk4

[Lluis Quintana-Murci @QuintanaMurci]

Review on how population genetics can greatly inform questions in human immunology @CellCellPress, see https://t.co/0JT3jsn1Xl... and a great Cell's 2019 Special Issue: Unraveling the Human Genome! See https://t.co/enccsIJM81

[Parham Lab @ParhamLab]

Our latest paper in collaboration with @PN0rmski and others out now, KIR and HLA class I diversity in Sub saharan African populations, 28 novel KIR alleles but surprisingly no new HLA alleles https://t.co/VYO5RAS4n3

[@JillahJillah.bsky.social @jillahjillah]

Super excited to see our paper finally out today @PNAS! A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson’s disease https://t.co/ljnTyZ10lM

[Parham Lab @ParhamLab]

Our new review with Dr Emily Wroblewski is out now, studying Hominid species to understand 'the evolutionary dance between two cooperating systems of MHC class I and NK cell receptors'
https://t.co/lJagLvM74V
@WUSTLbioanthro

[Malcolm Sim @mjwsim]

**🚨 NEW PRE-PRINT🚨 **

So excited to share our work on KIR2DS4!!!!

#NKcells #immunology #HLA

[MalmbergLab @MalmbergLab]

1/x. NK cell education is tightly linked to remodelling of the lysosomal compartment. Educated NK cells carry a greater cytotoxic payload in large dense-core secretory lysosomes (See T shirt). https://t.co/nzGeR4MDZo @jodegoodridge @CIM_Sweden @UiO_LifeSci @NatureComms

[Horowitz Lab @Icahn School of Medicine Mount Sinai @AmirHorowitz]

Thanks to Christina Tato @chanzuck biohub for very nice highlight of my 2013 CyTOF study with @ParhamLab and Catherine Blish published @NatRevImmunol. 1st report of human NK cells by CyTOF.
https://t.co/8z4xOUVVqv

[MalmbergLab @MalmbergLab]

Wow! So nice to see that the complex genetics of NK cell education revealed by @AmirHorowitz has a role in AML and Immunotherapy. Makes perfect sense!