PCF_SELECT

Multidisciplinary team working together to develop, validate, and implement liquid biopsies to improve the lives of patients with prostate cancer.

[PCF_SELECT @PCF_select]

.@PCF_SELECT #cfDNA assay detects #allelicimbalance (e.g. BRCA2, ATM, PTEN) in #prostatecancer plasma with high sensitivity. Consortium of @FrancescaBZNY @AttardLab @mishabeltran @ResearchWyatt @MarkARubin1 labs and teams! @PCF_Science @AIRC_it @CR_UK https://t.co/1Rw646GLWu

[Maite Bourlon @BourlonMaite]

The #IPCS26 @APCCC_Lugano with wonderful data in #prostatecancer

1️⃣Liquid biopsies
2️⃣Neuroendlcrine differentiation
🔵Epigenetics
🔴NEMO: Neuroendocrine monitoring panel
🟢Targeting methylation

@Silke_Gillessen @mishabeltran @DanaFarberNews @RodRogSan @feresparza06

[Michael Hofman @DrMHofman]

Clonal hematopoiesis (CH) in the @ANZUPtrials #TheraP study @ASCO #ASCO25 presented by Asli Munzur

■ ¹⁷⁷Lu-PSMA-617: higher incidence of emergent CH compared to cabazitaxel chemotherapy
■ Most new clonal hematopoiesis mutations ¹⁷⁷Lu-PSMA-617 fall in DNA damage repair response genes PPM1D, TP53, ATM, and CHEK2.
■ Clinical significance unclear but may become more relevant as radioligand therapy moves into earlier lines of treatment

@ResearchWyatt @AzadOncology

[pas_rescigno @PasRescigno]

Quick overview of news in Prostate Cancer from Esmo with @Ecastromarcos @AttardLab and Axel Heidenreich
Please follow https://t.co/6PRoCYDJd2

[Bernard-Tessier @alicebernardt]

Just out today in @jclinicalinvest 🚀
mHSPC is not one disease, but a kaleidoscope of biological states. We highlight what we know — and the key gaps that remain — on the road to precision medicine✨
Led by my mentor @mishabeltran 🙌
#ProstateCancer #mHSPC #PrecisionOncology

[Misha Beltran @mishabeltran]

Excited to share our new paper @NatureComms in collaboration with @RickmanLab, led by #RichaSingh @WeillCornell and @Bajji @DanaFarber #BeltranLab

[UroToday.com @urotoday]

Understanding ctDNA technology applications for cancer detection and characterization. @ResearchWyatt @VanProstateCtr joins @UroDocAsh @MDAndersonNews to break down the fundamentals of cell-free DNA and how ctDNA represents the tumor-derived portion of these fragments in the bloodstream. #WatchNow on UroToday > https://t.co/eb2gI07jCm

[Misha Beltran @mishabeltran]

Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer @NatureComms

https://t.co/b5Ss4UwxTW

Team science led by Kei Mizuno #BeltranLab @DanaFarber_GU @PCF_Science

[Francesca Demichelis @FrancescaBZNY]

Favorite study!

Germline-somatic tandems dictate cancer subtypes, provide clinical insights, and fuel molecularly informed studies.

Kudos: Blerta Stringa,
@Paola_Gasperini, Alessandro Alaimo, and
@LunardiLabCIBIO (co-last a!)
@NimaSharifiMD
https://t.co/cIHAS4PWFC
@UniTrento

[Michael Hofman @DrMHofman]

Stunning research from @EdmondMKwan on ctDNA in theranostics:
🧬Low ctDNA predicts better response with ¹⁷⁷Lu-PSMA-617 vs. cabazitaxel chemotherapy
⚠️PTEN alterations linked to worse outcomes on cabazitaxel
🧪ATM defects tied to favorable PSMA-617 results
🩻PET quantitative biomarkers (SUVmean) are additive

🌟We identify new candidate biomarkers for ¹⁷⁷Lu–PSMA-617 selection and ultimately expand the mCRPC predictive biomarker repertoire

Online at @NatureMedicine
https://t.co/WvEQS4ZWol

@ANZUPtrials #TheraP @MovemberAUS @PCFA
Support by @PCF_Science Challenge Award
@ResearchWyatt @AzadOncology @Prof_IanD

[Toni Choueiri, MD @DrChoueiri]

Elegant presentation from @ResearchWyatt on the evolution of ctDNA detection and characterization! Session chaired by @DanaFarber_GU's @OncoBellmunt and @BartsECMC 's @b_szabados

#GU25 @ASCO @OncoAlert @OncLive

[Francesca Demichelis @FrancescaBZNY]

Exciting work ahead on Large #Oncosomes at the @UniTrento @CIBIO_UniTrento with our team #DemichelisLab, Dolores Di Vizio @doldivizio at @CedarsSinai and Shannon Stott @svploeg at @MGH_RI funded by the @theNCI #PLUS

[Francesca Demichelis @FrancescaBZNY]

Proud of our LIG1 loss/PARP inhibition #SL study in @jclinicalinvest

by @GiuliaFracassi_ an @AIRC_it fellowship awardee
and @FraLo05 a @PCF_Science YIA

Collaborators: @quimmateo @FdAdF66

Relevant to #prostatecancer and beyond. Download it!
https://t.co/j3n4UdVdxl

[Toni Choueiri, MD @DrChoueiri]

PROSTATE Paper 2
Franseschini et al. developed a targeted DNA methylation assay for the detection of neuroendocrine prostate cancer using plasma cell-free DNA with an AUC > 0.93. Their assay also quantifies tumor content and offers a phenotype evidence score, which reflects various CRPC phenotypes. @CD_AACR . Lead our own @mishabeltran @DanaFarber_GU

https://t.co/DTrVCQKVCs

[Toni Choueiri, MD @DrChoueiri]

Heartbroken💔we lost Dr. Felix Feng— close friend, selfless collaborator, brilliant scientist & a man who saved many prostate cancer lives with a triad of generosity, kindness, & teamwork. We miss you @felixfengmd --too early my friend.

To all: please consider supporting this @ASTRO_org @AmericanCancer award in Felix name:

https://t.co/AcmQXJ9rP5?

[Andrea Miyahira @AndreaMiyahira]

Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️

[Andrea Miyahira @AndreaMiyahira]

The last time Felix stood on our stage, after a beautiful talk by @mishabeltran & intro by @AminaZoubeidi
💔💔💔
https://t.co/HUinL3Jc4X

[Dolores Di Vizio @doldivizio]

A tremendous loss for the cancer scientific community. @felixfengmd truly was one of the very best. I feel fortunate to have had the chance to meet him. This is heartbreaking but I want to remember him with the smile that always lit up his face 💔@MaryFengMD 💔

[Vancouver Prostate Centre @VanProstateCtr]

Exciting news! Dr. Alex Wyatt, a senior research scientist at the Vancouver Prostate Centre, is now the scientific director for the Clinical Cancer Genomics Program at BC Cancer. @ResearchWyatt
https://t.co/6rxS00Lh6T

[Michael Hofman @DrMHofman]

@mishabeltran sharing DLL3 PET/CT images including correlation with PSMA and FDG from @morr316 @PCF_Science
TACTICAL grant

#ESMO24 @myESMO