Jia Le Lee

Research interest: Ageing and Immunology! | Schmidt Science Fellow @harvardmed | PhD alum @Cambridge_Uni | @astar_research

[Jia Le Lee @plusle17]

Game-changing study on same-slide spatial proteomics and transcriptomics linking transcriptomics to cell type, state, and tissue landscape, enabling more in-depth biological studies 🤯 Huge congrats to the team!

[YaoYu Yeo @yeoyaoyu]

Spatial proteomics & transcriptomics are amazing technologies that have transformed how we study diseases. Can we do more?

Here's our new preprint that combines both assays into one! (massive thanks to @SizunJ @Yuzhou_Chang Huaying @QinMaBMBL et al.

https://t.co/I0bsLsjhXk

[Nature Methods @naturemethods]

The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳

For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread.

https://t.co/phXooJzJda

[Jia Le Lee @plusle17]

Thoroughly enjoyed my first Science Leadership Program with the fellow 2024s! Amazing workshops, deep discussions, and fun team-building. Huge thanks to the @SchmidtFellows team and senior fellows for making it happen. Grateful to be part of this inspiring community!

[Schmidt Science Fellows @SchmidtFellows]

Culture, community, ambition, risk, failure, and perseverance. Inclusion, perspective, and reflection...no punting...but pasta, and how to change the world. That's a wrap on the first Science Leadership Program for our 2024 Fellows.Thanks to all who made it special. Safe travels.

[James Lee @Dr_James_Lee]

There's been amazing coverage of our new paper @Nature https://t.co/qkrUksBYVW but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...

[Nico Gagelmann @NicoGagelmann]

Tumor immunology, simplified😅

[Jia Le Lee @plusle17]

@LintermanLab Thank you Michelle! 😊 Always grateful for your mentorship and support!

[Waggoner Lab @LabWaggoner]

Following influenza virus rechallenge, lung resident but not circulating memory B cells differentiate into plasma cells near infected alveoli (outside iBALTs) with signals from innate (NK) cells @JExpMed @Tal_Arnon_Lab
https://t.co/gRRCLTZIx1

[Jia Le Lee @plusle17]

@oliwiagoldman @astar_research Thanks Olivia! Congratulations to you too 🎉 Can’t wait to meet in person!

[Jia Le Lee @plusle17]

Very honored and humbled to be selected as a 2024 Schmidt Science Fellow (and to be one of the firsts from 🇸🇬)! Thank you to my mentors, colleagues, family, friends,and @astar_research for their support. Looking forward to learning, growing, and driving meaningful Science!

[Schmidt Science Fellows @SchmidtFellows]

We’re so excited to announce our 2024 Schmidt Science Fellows.  32 exceptional early career scientists will join our global community to pursue interdisciplinary research and help change how science is done. https://t.co/QDbIT042gG

[Jia Le Lee @plusle17]

@aliceroselyn Thank you Alice!! 😊

[Jia Le Lee @plusle17]

Special shoutout to @LintermanLab, Anis, Prof Chu, @SizunJ, @aliceroselyn, @Stephane_Guil, Hendrik, and Precious for their help and support for my application! And @_audreylow for encouraging me to apply when I didn’t believe in myself. Extremely thankful for all of you 😊

[Iannacone Lab @iannaconelab]

💥 Exciting News! Our latest research is now online @NatImmunol! Discover how prior infection or vaccination provides antibody-independent protection against heterologous SARS-CoV-2 challenge! 🧵🔬 (1/10)
https://t.co/G3EYjGut9q

2/ 🛡️ Shifting paradigms, our research highlights T cells' paramount role in defending against COVID-19 beyond antibody responses. Even in the complete absence of antibodies, T cells stand guard.

3/ 🧬 Our study utilized advanced mouse models, including a pioneering human/mouse ACE2 hybrid, to unveil that T cell immunity effectively counters various SARS-CoV-2 strains without relying on antibodies.

4/ 💪 Highlight of our findings: CD8+ T cells are crucial for combating severe infections, complemented by CD4+ T cells in less severe cases. The linchpin? Interferon-gamma (IFN-γ), driving this antibody-independent protection.

5/ 🔄 Demonstrated across models mimicking the spectrum of disease severity, this research shows that T cells not only prevent disease but also curb early SARS-CoV-2 replication.

6/ 📚 Building on the collective efforts of many in the field, our study underscores T cells' essential and sufficient role in safeguarding against SARS-CoV-2, reinforcing the critical importance of cellular immunity in the fight against COVID-19.

7/ 🌐 While our findings support vaccine strategies enhancing T cell responses, it's essential to acknowledge the efficacy of current vaccines in eliciting T cell immunity. We advocate for evaluating T cell responses alongside antibodies to fully assess vaccine effectiveness and explore targeted strategies for optimal T cell activation.

8/ 🙌 A heartfelt thank you to our incredible team and collaborators, especially lead author @ValeFuma91, along with key contributors Micol Ravà and Davide Marotta, as well as our collaborators Luca Guidotti, Marco Bianchi, and Raffaele De Francesco.

9/ 🌟Appreciation to our supporters @ERC, @AIRC_it, @EMBO_YIP, @ArmeniseHarvard, @mur_gov_, @SanRaffaeleMI, @MyUniSR, Fondazione SAME, Fondazione Prossimo Mio. Thanks also to our reviewers and Nick Bernard for their invaluable contributions to our journey.

10/ Dive deeper into our study to grasp its impact on immunology and future vaccine development. We're eager to hear your thoughts and engage in discussions! https://t.co/G3EYjGut9q. Your feedback and insights are invaluable. 📖💭

[Jia Le Lee @plusle17]

Congratulations @yeoyaoyu, @SizunJ, and team!!

[Sizun Jiang @SizunJ]

Whats the physiological role of tumor viruses? How do we systematically study the tissue microenvironment in a spatially iterative fashion?

Well here's a fun paper! By @yeoyaoyu Huaying @ZhuBokai Yunhao, w/ Margaret Shipp, Scott Rodig & more
https://t.co/euZmY3Jv2P

[Sizun Jiang @SizunJ]

Wanna dissect host-microbiome interactions in situ? Incredibly excited to share work from @BokaiZhu with @GarryPNolan, and @shaleklab @MikeAngeloLab @yeoyaoyu @xavi_r_c @hanimal725 and others

[Jia Le Lee @plusle17]

@immunoliugy @ragoninstitute @ForbesUnder30 Congrats Sophia!! 😊

[EdjCarr @EdjCarr]

How to study mucosal SARS-CoV-2 neutralising antibodies 📈 with live virus 🦠 at scale ⚖️ from VTM 🧪

📸 Current mRNA vaccines boost mucosal neutr.

Assay is ideal tool 🔨 to evaluate next gen mucosal vaccines

Unpacked in great 🧵👇by @MaryYiWeiWu

⬇️
https://t.co/b2S6AzSGzk

[Jia Le Lee @plusle17]

@Xin_Ge_ Coooool! I got mine secondhand from the Harvard Bookstore 😆

[Jia Le Lee @plusle17]

This weekend’s read! Did you know the origin of the name of cancer (the disease)? 🦀 I didn’t.

[Maxim Artyomov @maxim_artyomov]

If you ever wanted to *really* know what is happening to PBMC in healthy aging - now you know!
Just out in @ImmunityCP , our latest work in immune aging - dissection of >300 PBMC samples aged from 25 to 85 years. Huge dataset and detailed annotations.
https://t.co/1LRuA0yhUQ

[Jia Le Lee @plusle17]

@KlausOkken @beecellnumbers @LintermanLab @SizunJ Thanks for the kind words, Klaus. I enjoyed the Viva and learnt a lot too. Thanks to you and @beecellnumbers, it didn’t feel as long as it was!

[Jia Le Lee @plusle17]

Passed my Viva! Thank you @KlausOkken and @beecellnumbers for the insightful discussions.

Although this title page only has my name, I have many to thank for this milestone- in particular Michelle and the @LintermanLab!

And one week into post-doc at the Jiang Lab @SizunJ 😎