Vikram Prasad

Scientist | Striated Muscle Biology |

[Waggoner Lab @LabWaggoner]

New @biorxivpreprint preprint from @doug_millay lab @CincyResearch
mRNA transcription in skeletal muscle drives growth and determines nuclear accretion
https://t.co/f4eiY6gKUk

[Cincinnati Children’s Research @CincyResearch]

We’re proud to celebrate @CincyKidsHeart's Jeff Molkentin, PhD, for receiving @UCincyMedicine's 2025 Daniel Drake Medal—college's highest honor! His groundbreaking work in cardiovascular biology continues to advance science & inspire next-gen researchers: https://t.co/m05nWnU3VG

[Prachee Avasthi @PracheeAC]

Right now is the best chance the scientific community has ever had to end the artificial scarcity of academic journals.

Check out my new op-ed urging @NIH @NIHDirector_Jay to disallow taxpayer dollars towards journal publication fees — something both publishers and scientists have played a role in perpetuating.

The last day for public comment on this topic is Monday, Sept 15. It’s time to unleash science.

Links in 🧵

[Prof. Nikolai Slavov @slavov_n]

This rate of validation suggests that affinity reagents such as antibodies should be considered non-specific until proven otherwise:

357 validated antibodies out of 1,124 tested.

.

[Kehat Lab @KehatLab]

Found in translation: Using single-molecule imaging, we show that ERK signaling controls where protein translation happens during hypertrophic stimulation in #cardiomyocytes —revealing a dynamic response. @itaie21 #Biorxivpreprint #cardiotwitter
Read: https://t.co/HzaFGLInef

[Dr Kate Weeks @k8weeks]

Did you know heart muscle cells can have multiple nuclei? (See pic on my profile for example!)

Within each nucleus, there can be multiple sets of chromosomes (polyploidy). 🧬🧬🧬🧬

This paper in @JMCCardiology describes a new method for assessing polyploidy in cardiomyocytes.

[Rüegg Lab @RueggLab]

Myc and muscle growth: necessary in muscle stem cells, dispensable in muscle fibers and harmful if overexpressed. Check out our latest work https://t.co/ACbr55RXuz in @NatureComms, where we explore the role of Myc in muscle growth and more.

[Eldad Tzahor @Tzahore]

Super excited to share that our manuscript is finally OUT @CellSystems!!🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. https://t.co/pZhWBCyPtG🧵(1/)

[Hesham Sadek @heshamasadek]

Happy to share our latest work on the role of induced cytokinesis in regulation of cardiomyocyte nucleation and myocardial regeneration. Years of hard work by @NicholasLamPhD ! Many thanks to our collaborators @Alisson48184507 and @LiorZangi

[Hesham Sadek @heshamasadek]

Excited to share the latest collaboration spearheaded by @oibergmann @FrisenJonas @StavrosDrakos this work started with our Leducq consortium 6 years ago showing that LVAD responders have a higher rate of new myocytes formation. https://t.co/pjNcPtRyzy

[Jen Kwong @KwongLab]

Excited to share our work on the mitochondrial citrate carrier, a new regulator of #CHD and metabolic reprogramming in the developing #heart. Congrats to Chiemela Ohanele, @JPeoples88, @nasabgee and our amazing collaborators @AnjaKarlstaedt @FaundezLab! #mitochondria

[Matthew S. Alexander @Matt_Muscle_Guy]

Nice @NatureComms study from @doug_millay & colleagues: Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations. https://t.co/oHXPTmrGYH

[Cat Mak @CatMak23]

Excited to share our latest work in @JMCCardiology demonstrating that the microprotein ALN regulates cardiomyocyte Ca2+ handling via integration of neuroendocrine signaling w/ SERCA2a activity🫀 Congrats @keira_hassel & our amazing team of collaborators💪🏼

https://t.co/8vJ1fXuYd3

[Circulation @CircAHA]

YAP activation induces adult cardiomyocyte division by promoting cytoskeleton disassembly and mitotic rounding @jkim @RichGangLi @ShijieLiu_CCHMC @jmartinlab https://t.co/mEm6wThu67

[Peyman Milanfar @docmilanfar]

Two basic concepts are often conflated:

Sample Standard Deviation (SD) vs Standard Err (SE)

Say you want to estimate m=𝔼(x) from N independent samples xᵢ. A typical choice is the average or "sample" mean m̂

But how stable is this? That's what Standard Error tells you:

1/6

[Jan Skotheim @JanSkotheim]

Mike Lanz's latest paper from our group on what happens when cells get too big just came out in NSMB. Read all about it at the link below. Diluting the genome produces a response similar to limiting an essential nutrient https://t.co/Jeadm0PszJ

[UC Pharmacology, Physiology, and Neurobiology Dept @UCPPNDept]

Research Associate Michelle Nieman (Lorenz lab) was elected to the University's Staff Senate, which advises the University's leadership. @UCincyMedicine

[Kehat Lab @KehatLab]

Check out our new paper @jclinicalinvest by the great @Ramihdd and @shkedio. We show that the protein RPSA is required for ribosome localization, localized translation, and the maintenance of the sarcomere. https://t.co/C23OfsbxaW

[Michaela Patterson @caelagamoo]

Some have touted Runx1 as a marker of cardiomyocyte dedifferentiation... we're not so sure. What we do know is that it can induce cell cycle re-entry, but that's not always a good thing. Check out Akins et al. Thanks @ajpheartcirc! https://t.co/Lqq162aUMK

[Davy Vanhoutte @davy_vanhoutte]

Hot off the presses:
#Excited to share our latest work on how #Thrombospondin-1 directly incites #SkeletalMuscle #Atrophy through TGFb-Smad2/3-ATF4 signaling!

Grateful to #MolkentinLab and all who contributed to this work 😊

Check it out @CellReports 👇https://t.co/26qVbX0Atw