🚨T-minus 3️⃣ months to go until the @AmerUrological In-Service and @UroOnc OKAT exams ➡️ great time to get ahold of @HighYieldUro 2026 📖🚀 https://t.co/b7EVZjnzDY
💥Phase III BART trial (n=153) in locally advanced #BladderCancer after cystectomy + chemo:
🔹 RT (n=77) vs Obs (n=76)
🔹2-yr locoregional recurrence: 8% RT vs 26% Obs (p=0.006)
🔹OS trend ↑RT (68% vs 57%), not sig
🔹No ↑ severe late adverse events
👉Adjuvant RT ↑ control & DFS, esp T3/4 & N+ pts. #ASTRO25 #RadOnc
Just completed the first FANS ureteroscopy at @PH_Surgery using the @DornierMedTech Hoover suction access sheath. A true game changer for the management of kidney stones!
Bladder cancer care is evolving fast! From NMIBC to mUC, learn more with Drs. Sia Daneshmand (@siadaneshmand), Laura Bukavina (@laurabukavinamd), Matthew D. Galsky (@MattGalsky), & Sarah P. Psutka, MD, MS, FACS (@spsutkaMD)! https://t.co/WhovTmtHaB @PeerView
We need to be thoughtful about what our patients want and counsel them well so they make the best decision possible!!
Especially in the era of ever improvements in bladder sparing efficacy…. This data is super valuable
LVI is tough. With our improved management and therapies I am generally aggressive in promoting bladder sparing for NMIBC - but this gives pause: T1 with LVI had higher node positivity rates than MIBC without LVI, at least in NCDB 2004-2014..
Need large granular series that include more variables (blue light, presence of LVI at re-TURBT) and contemporary agents (especially immune) to get more answers
https://t.co/bfOOS74gih
Editor's Choice: Risk-adjusted Screening for Prostate Cancer—Defining the Low-risk Group by Data from the PROBASE Trial by Agne Krilaviciute et al
Read the full article here: https://t.co/onQxNk0peU
Come back later to read the Editorial!
#UroSoMe#MedTwitter#eururol #editorschoice #highlightarticle #ProstateCancer #PCa #Spotlight
@GGiannarini
🚨 Promising alternative to BCG for #NMIBC! Drs. @SHPatelMD1 & @MaxKates@brady_urology sit down with @UroCancerMD @VUMCurology to discuss phase II trial results: 100% complete response at 3 months & 92% at 12 months with gemcitabine + docetaxel. Key takeaways: combination therapy logistics, maintenance strategies, & BCG shortage solutions. #WatchNow > https://t.co/tzbqxd2zp0 @urogabe
END OF YEAR TOP ALL CANCER TRIALS in 2024!
JUST in on 1 JAN 2025:
Paper 1:
#neoadjuvant checkpoint inhibitor Phase 3 trial in melanoma! #NADINA trial shows ipi+nivo significantly improves EFS vs. adjuvant nivo alone (HR 0.32, p<0.0001). #ASCO24 plenary #Melanoma @A@ASCO@ProfCUBlankNKI
https://t.co/3ndFElEAA8
Nectin-4 is the target for Enfortumab Vedotin and is widely expressed in UC (median 275/300) . EV302 is 1st randomised trial to explore its relationship with response. IHC results show no clear relationship between Nectin-4 and outcome (RR,PFS,OS) or PD-L1 #ESMO2024
Robot-assisted Radical Cystectomy with IUD Versus Open Radical Cystectomy: 3-Year Outcomes from a Randomized Controlled Trial
Confirms: similar outcomes, shorter OR time with ORC, lower EBL with RARC
https://t.co/xG4oDQFrGE
#BladderCancer
Enfortumab + Pembro outperforms platinum chemotherapy in advanced UC with a doubling of PFS and a halving of the risk of death @nejm. G3/4 AEs of 56% for EVP vs 70% for chemo & CR=29%. Editorial by @gniegisch ‘EVP is the new standard against which future trials must be compared’
@Agarwal_CaB@UroDocAsh@joanfundi What’s interesting is we have started to experiment with ctcs with comp like signatera. example of this is we had pt with nac. Post nac signatera elevated. Then rc with lnd. N1. Post rc signatera 0. Unclear what this means,prospective follow up correlating recurrence needed