Scott Lab

We are a lab at University of Pennsylvania @pennvet investigating host-pathogen interactions.

[Scott Lab @pscottlab]

Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity https://t.co/ZTnXaRiGyd

[Camila Farias Amorim, Ph.D @amorim_cfa]

A #translational study evaluating the role of #skin #microbiome in driving IL-1b #immunopathology in a parasitic infection, cutaneous #leishmaniasis.
@hostmicrobe @tpsinglab @novaislab @LovinsTori @pscottlab @HarrisOnTheSkin #eGrice https://t.co/al3pRoheRH

[Camila Farias Amorim, Ph.D @amorim_cfa]

Come to work in a GREAT multidisciplinary team @Penn super interested in Host-Pathogen interactions and cutting-edge high-throughput NGS single-cell technologies #JobAlert #Bioinformatician💻🐛🧫

[Daniel Beiting @hostmicrobe]

Start your New Year with a new job! We're hiring a bioinformatics specialist to lead analyses of single cell genomic data 💻. Great opp. to work w/ a large and interdisciplinary team of immunologists and infectious disease researchers. Apply below!

https://t.co/8rpIa5WWOk

[Journal of Experimental Medicine @JExpMed]

Findings by @tpsinglab @pscottlab and colleagues @pennvet @PennMedicine have clinical ramifications for cutaneous leishmaniasis and other skin diseases associated with a dysregulated microbiome when Tregs are limited or dysfunctional. https://t.co/nQtgy6GLt0

#InfectiousDisease

[Journal of Experimental Medicine @JExpMed]

Insights: Michail Lionakis @LionakisLab @NIAIDNews discusses study from @tpsinglab, @pscottlab et al. (https://t.co/nQtgy6GLt0) showing that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth: https://t.co/hlvMvrqZ9M

[Tej Pratap Singh @tpsinglab]

Learned more about S. aureus as editor of this excellent review @WolfDermGraz @PennSbdrc @pscottlab
Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis https://t.co/R2L0RfHoCF

[Camila Farias Amorim, Ph.D @amorim_cfa]

This cover is amazing! Our recent publication is here! Evaluating the role of #skin #microbiome in driving IL-1b #immunopathology in cutaneous #leishmaniasis

[Tej Pratap Singh @tpsinglab]

We highlight how the human microbiome can shape disease outcomes in cutaneous leishmaniasis and suggest pathways toward host-directed therapies to mitigate the inflammatory consequences. Nice work @amorim_cfa @microbiome @RNAseq @immunology
https://t.co/sTRZ2bottV

[Journal of Experimental Medicine @JExpMed]

Regulatory T cells control Staphylococcus aureus and disease severity of cutaneous leishmaniasis, say Tej Pratap Singh @tpsinglab, Phillip Scott @pscottlab and colleagues @pennvet @PennMedicine: https://t.co/nQtgy6GLt0

#InfectiousDisease #HostDefense

[Journal of Experimental Medicine @JExpMed]

Tregs tame skin bacteria and IFN-γ-associated pathology. Michail Lionakis @LionakisLab @NIAIDNews discusses recent study from @tpsinglab, @pscottlab et al (https://t.co/nQtgy6Hjiy) in new Insights: https://t.co/hlvMvrrwZk

#InfectiousDisease #HostDefense #Tolerance

[Camila Farias Amorim, Ph.D @amorim_cfa]

A #translational study evaluating the role of #skin #microbiome in driving IL-1b #immunopathology in a parasitic infection, cutaneous #leishmaniasis.
@hostmicrobe @tpsinglab @novaislab @LovinsTori @pscottlab @HarrisOnTheSkin #eGrice https://t.co/al3pRoheRH

[Journal of Experimental Medicine @JExpMed]

Insights from @LionakisLab: Mibrobial dysbiosis worsens cutaneous leishmaniasis. @tpsinglab, @pscottlab et al (https://t.co/nQtgy6GLt0) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth https://t.co/hlvMvrqZ9M

[Rockefeller U. Press @RockUPress]

Insights @JExpMed by @LionakisLab: Mibrobial dysbiosis worsens cutaneous leishmaniasis. @tpsinglab, @pscottlab et al (https://t.co/5n09I6JMgp) show that Rorγt+ regulatory T cells suppress pathogenic IFN-γ responses to control Staphylococcus aureus growth https://t.co/rJwPrV9YVe

[Camila Farias Amorim, Ph.D @amorim_cfa]

We appreciate immensely the @LionakisLab, for your insights on our recent work showing that Foxp3+ Rorγt+ Tregs suppress pathogenic IFN-γ responses to control S. aureus growth @tpsinglab @pscottlab #eGrice

[Scott Lab @pscottlab]

Led by @tpsinglab, collab with @amorim_cfa, @LovinsTori , Charles Bradley, Carvalhos labs and Elizabeth Grice 🧫

#translationalresearch #infectiousdiseases #inflammation #immunology #Tcell #bacteria #parasite #omics #DualRNAseq #datascience #datamodeling #clinicaloutcome

[Journal of Experimental Medicine @JExpMed]

Study by Singh, Scott et al. @PennMedicine involving mice and #Leishmania braziliensis patients reveals that Treg levels function as a rheostat, controlling bacteria in the skin & influencing whether bacteria induce IL-17 or IFN-γ-mediated immunopathology. https://t.co/nQtgy6GLt0

[Boris Striepen @striepenlab]

Looking to study parasites for your PhD training? Join us a Penn! Great breadth cell biology, genomics, immunity, drug and vaccine development. Great labs & environment! @KingOfPathogens @yiweichang @odomjohnlab @DeBroski1 @hostmicrobe @PoveLab @omartheharb @pscottlab @dsro5os

[Waggoner Lab @LabWaggoner]

Leishmania braziliensis patients & mouse models reveal that Treg levels function as a rheostat, controlling bacteria in the skin and influencing whether bacteria induce IL-17 or IFN-γ–mediated immunopathology @JExpMed @pscottlab
https://t.co/ra7rjLYVqs

[ChrisHunter @KingOfPathogens]

⁦ok @CytokineSociety⁩ members ⁦@ImmunologyAAI⁩ stop by booth and learn about the annual meeting in Athens

[Camila Farias Amorim, Ph.D @amorim_cfa]

A great meeting for our family of immuno•parasitologists at the Woods Hole Conf 2023 🦠🪱

I got awards for our current study!
@novaislab @pscottlab #DrAlanSher @MBLBoP @tpsinglab @LovinsTori #DrElizabethGrice @WHIP42266646
#Immunology #parasites #microbiome #science

[Camila Farias Amorim, Ph.D @amorim_cfa]

Being Dr. Alan Sher's scientific granddaughter is a real privilege and honor. Today I had the opportunity to hear again what I've been learning from @pscottlab over the years: "The parasites teach us a lot about immunology." at @MBLScience @MBLBoP @WHIP42266646