Piyush Sharma

Scientist @Stjude exploring mysterious world of immunometabolism | Immunologist | views are my own #tcells #immunometabolism

[Piyush Sharma @PSharma_PhD]

Amazing study highlighting the beneficial role of methionine metabolism from Janelle Ayers lab at @salkinstitute.

[Cell Metabolism @Cell_Metabolism]

Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines https://t.co/zgwr1gK3wp

[Piyush Sharma @PSharma_PhD]

Amazing study from @RoychoudhuriLab highlighting the next-gen genetic manipulation to tweak the right amount of protein expression to enhance T cell function in cancers. Kudos to the authors.
Check it out https://t.co/XgAu2yiBeZ

#tcellexhaustion #tcells

[Piyush Sharma @PSharma_PhD]

Excited to share our latest story in @NatImmunol
We’ve uncovered a new metabolic switch in T cell activation that shapes their fate—offering a new perspective into T cell exhaustion
@StJudeResearch

Full story : https://t.co/AMPrIQ0ZY8

#tcells #immunometabolism #cancer

[Piyush Sharma @PSharma_PhD]

Check out our chapter on ‘Adaptive Immunity and Metabolism’, in a recently published book by @Elsevier, where we highlighted the current understanding of how metabolites regulate adaptive immune system development and their response in diseases.

https://t.co/IQTidyFAsq

[Piyush Sharma @PSharma_PhD]

Our latest preprint discovers the role of methionine metabolism in regulating TCR signalling. We identified a methylation event of KCa3.1 crucial for regulating NFAT mediated T cell activation and subsequent exhaustion.
#immunometabolism

https://t.co/qXsGtJDsVV

[Piyush Sharma @PSharma_PhD]

Amazing study from @Vignali_Lab showing the synergistic effect of PD1 and Lag-3 during T cell exhaustion in anti-tumour immunity. https://t.co/hnJlkFR872

[Piyush Sharma @PSharma_PhD]

@Brenner_Lab @Cell_Metabolism @LIH_Luxembourg @FnrLux @uni_lu @science_lu @ImmunoMet @ImmunoMetEurope That’s amazing! Congratulations Dirk.

[Piyush Sharma @PSharma_PhD]

Is the publication cost hindering science? This should be a major topic of discussion especially when labs are struggling to acquire funds, and sometimes even paying out of pocket to publish. With OA cost over $12k, is it even sustainable? Read more at https://t.co/yWsONLqDbl

[Institute of Molecular Immunology @KnolleLab]

We are excited that our study on the liver immune rheostat regulating CD8 T cell immunity in chronic HBV infection is published!🥳 @nature (https://t.co/5iLVpda4lM)

[Piyush Sharma @PSharma_PhD]

Excellent review by @r_wedan and @dr_nowinski in @Cell_Metabolism elaborating the role of mitochondrial FAS in oxidative metabolism.

[Piyush Sharma @PSharma_PhD]

A very exciting study from @hongbo_chi Lab published in @Nature . Congratulations to everyone involved. A must read, if you want to deep dive in the field of T cell tumour immunology.
#stjuderesearch #tcell #tumourimmunology #tcellexhaustion

[Hongbo Chi @hongbo_chi]

Excited to share our latest studies published in Nature yesterday “Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer”@Nature @StJudeResearch
https://t.co/6mXQxwQsFZ

[Paul G Thomas @PGTimmune]

Have you ever wondered why some people get more sick from the flu than others?

Check out our latest paper from @rmettelman and @aanaishe exploring diverse immune correlates of protection against flu https://t.co/drANgKtNNH

A brief 🧵

[Piyush Sharma @PSharma_PhD]

Exciting study published in @NatImmunol by @philiplabvandy lab showing fate decision at early stages of T cell activation in cancer. Check it out.
#tcell #tcellexhaustion #tcellfate

[Philip Lab @philiplabvandy]

We are excited to share our work published today in @NatImmunol by @MRudloffMSTP, the whole @PhilipLabVandy team @VUMCDiscoveries, and in collaboration with our fantastic computational biology collaborators @dbetel and his group @WeillCornell. 1/7
https://t.co/zaXpn9sF91

[Piyush Sharma @PSharma_PhD]

It was indeed an intense course but with awesome instructors, the time went by too fast. Made new connections and friends. Thanks to all the instructors and TA’s for making the last two weeks filled with science, discussions and fun parties. @cshlmetabo @CSHL #metabolomics

[Kaechlab (Sue Kaech) @Tcellogic]

Super excited to share with you are our newest paper on cBAF regulating CD8+ T cell fates and long-term memory! Great collaboration with @HargreavesLab and superstars Bryan McDonald, Brent Chick, Nasiha Ahmed! https://t.co/TonsO6Qacz

[Cell Metabolism @Cell_Metabolism]

Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment https://t.co/NOmouvL8Yz

[Piyush Sharma @PSharma_PhD]

Awesome study from @ChrMoussion Lab about dynamics of tumor growth, published in @Nature . They used a novel STAMP technique and dissected the interplay between tumor growth and immune cells. Congratulations to all the authors.

https://t.co/fqaUOVhRRt

[St. Jude Research @StJudeResearch]

Join us in congratulating scientist Dr. M. Madan Babu, just named a @royalsociety Fellow for his pioneering data science-based strategies to reveal fundamental principles in biological systems. Discover more about his work. https://t.co/VuIYDkcj1z @m_madan_babu

[Piyush Sharma @PSharma_PhD]

I applaud @HHMINEWS for the effort towards betterment of postdocs. I still argue that postdocs should be paid according to their location. 70k is ok for certain cities but not for cities like SF or Boston esp with the current inflation. #dynamicsalary #postdocs #betterscience

[HHMI @hhmi_science]

HHMI is implementing a new salary scale for HHMI-employed postdoctoral researchers, effective April 9, 2023. (1/4)

https://t.co/LT7tq7Mcfw

[Brenner Lab @Brenner_Lab]

Thrilled by the connection between metabolism & T cell function?
Our lab @LIH_Luxembourg is looking for a new PhD candidate to study metabolic circuits between cancer cells & T cells.
Have look at the Canbio2 graduate school & apply here (project 10):👇
https://t.co/JcG4o0EEE7