Renaud Mevel

[Zaki @zaki_wilmot]

Thrilled that our work profiling hemogenic endothelium differentiation is featured on the cover page of blood https://t.co/wRaRKpZ6tl. Excellent summary and commentary by @YuLan26190217 https://t.co/LcX9dEOnEz

[Olivier Elemento @ElementoLab]

Fascinating use of single-cell RNAseq in metastatic biopsies and matched tumor organoids to identify diversity of tumor cell states and the role of tumor microenvironment in modulating this diversity. Great work by @shaleklab! https://t.co/PFkttO4YAE

[Lior Pachter @lpachter]

I've found that it's fairly common for faculty to respond to a student's request for a recommendation letter by telling the student to write their own letter. I was first asked to do this by one of my recommenders when I applied for postdocs. It's a terrible practice.

[Owen King @Owen__King]

Lakes and glaciers

[Esther Baena @estherbaena]

Are you interested in the differences of prostate tumours based on their spatial distribution?
You may enjoy our new #perspective review https://t.co/uv90Ijq5Lh in @NatRevUrol discussing the role of #prostate #zones in #prostatecancer @CRUMI @MCRCnews @ProstateUK @PCFnews

[CRUK Manchester Institute @CRUK_MI]

🔥Hot off the press @NaturePortfolio!🔥
Fantastic review shows how understanding the zonal nature of the prostate can positively impact prostate cancer research.
From our Prostate Oncobiology group (@estherbaena) & collaborators @MCRCnews @TheChristieNHS
https://t.co/faoPLwA92q

[Amin Ali @DrAminAli]

Very pleased to share our publication in @NatRevUrol
https://t.co/9KGGpmKeYi
Highlighting the role in #prostatezones in cancer development

A big shout out to my co-authors Alex Du Feu, @PedroOlivps , @achoud72 , Rob Bristow and @estherbaena for making this happen

[Bartomeu Colom @Bartomeu_Colom]

Out today @Nature! Human tissues accumulate cancer-driver mutations with age, yet tumor formation remains rare, why!? We show that mutant clones in the normal epithelium can have a tumor-protective role by outcompeting and eliminating nascent tumors. https://t.co/GfBaLNHvBq

[Matt Jones @MattG_Jones]

We're ecstatic to present our manuscript on recording the evolutionary dynamics in a mouse model of lung cancer with an evolving lineage tracer. Congrats to @dianyang1117 for co-leading and @JswLab @YosefLab @LabJacks for this joint effort. Biorxiv link: https://t.co/L6CGpkBm4v

[Renaud Mevel @r_mvl]

Great opportunity!

[Clémentine Le Magnen @ClemLeMagnen]

📢 We have an open position in our lab @UniSpitalBasel for a #postdoctoral scientist to work on #prostatecancer using patient-derived #organoids and #singlecell technologies 🧫🧬🔬
A big thanks to @snsf_ch for funding our project! Please share and apply: https://t.co/LxVJsZhkHt

[Jason Sheltzer @JSheltzer]

Next week, the Nobel Prizes will be announced. I don’t know who will win - but I think that we can make some educated guesses about who might:

[Zaki @zaki_wilmot]

We are excited to share our latest work from Stem Cell Biology lab @GeorgesStem @CRUK_MI entitled ‘Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE’ https://t.co/AonBy1sWDm. @BloodJournal (1/14)

[Rahul Satija @satijalab]

Our new preprint introducing scCUT&Tag-pro (single-cell profiling of histone modifications and cell surface proteins), scChromHMM (inferring chromatin states in single cells), and an integrated reference of 9 molecular modalities in human PBMC: https://t.co/2ypttjJDRt

[Claus Jorgensen 🇪🇺🇩🇰 @claus_jorgensen]

Very pleased to present our latest work, which describes a fully synthetic scaffold supporting human and murine pancreatic organoids and models important features of the PDA microenvironment in vitro @MITdeptofBE @CRUK_MI @MCRCnews https://t.co/W9vkinzZvU

[Feng Zhang @zhangf]

CRISPR technologies are powerful gene editing tools because they are programmable. We are excited to describe 3 new programmable systems, IscB, IsrB, and TnpB, some of the most abundant genes on the planet, with potential for gene editing. @ScienceMagazine https://t.co/dY8FXBYIM8

[Chris Tape @christophertape]

Very proud to share my lab’s new paper: ‘Multiplexed Single-Cell Analysis of Organoid Signalling Networks’ out today in @NatureProtocols (1/11) https://t.co/90XCvJ5Ezs

[preLights @preLights]

"Light-sheet illumination of the intestinal organoid family tree with LSTree"
preLight by @osvaldoics highlighting a preprint by @GustavoQGMed and @priscaliberali https://t.co/71hgc0AZ9v

[Lior Pachter @lpachter]

It's time to stop making t-SNE & UMAP plots. In a new preprint w/ Tara Chari we show that while they display some correlation with the underlying high-dimension data, they don't preserve local or global structure & are misleading. They're also arbitrary.🧵https://t.co/XkAOTKlOcs

[Gladell Paner, MD @GladellPaner]

Cribriform pattern is bad! Cribriform #prostate carcinoma invading into #bladder muscular wall (pT4).

Cribriform is worst among Gleason pattern 4 and should be reported if identified in biopsies and RPs. 😈#GUPath

[Feng Zhang @zhangf]

We are really excited to share our work on a new modular RNA delivery technology called SEND, built from endogenous components found in the mammalian genome. @ScienceMagazine https://t.co/0HRvKkDAFV