Kishu Ranjan, PhD

Scientist @Yale University. #immunotherapy #drugdiscovery

[Kishu Ranjan, PhD @ranjankishu]

Honored to meet Dr. Jim Allison, pioneer in cancer immunotherapy, whose work on CTLA-4 checkpoint blockade revolutionized cancer treatment. Grateful to present our research at the Lung SPORE meeting hosted by @MDAndersonNews @UTSouthwestern.

@YaleCancer @yalepathology @theNCI

[Yale Cancer Center @YaleCancer]

Dr. Kurt Schalper shares developments in spatial analysis #AACR25 plenary, noting that spatial immune heterogeneity is not a passive phenomenon—higher levels are associated with worse outcomes. @AACR @yalepathology @SmilowCancer @YaleMed

[Yale Cancer Center @YaleCancer]

Research from Dr. Kurt Schalper, @ranjankishu + @yalepathology colleagues in @biomedcentral highlights previously unrecognized functions of TAP2 and shows how it contributes to immune evasion and resistance to immunotherapy in #lungcancer. #NSCLC
https://t.co/yJTaDlLSfL
@SmilowCancer @YaleMed @YNHH

[Kishu Ranjan, PhD @ranjankishu]

Advancing #Personalized #Immunotherapy! We explore new roles of TAP2 beyond antigen presentation, shedding light on its impact on adaptive immune evasion and resistance to immunotherapy.
@Yale @theNCI @YaleMed @AACR @sitcancer #biomarker #lung cancer
https://t.co/UEoWY2Ggr9

[Kishu Ranjan, PhD @ranjankishu]

Teaming up with incredible colleagues, we carefully curated a collection of perspectives and research on the transformative impact of engineered medicines in cancer immunotherapy. #Cancer #Immunotherapy @sitcancer @yalepathology @YaleMed @FrontMedicine
https://t.co/86tjuUK3XP

[Kishu Ranjan, PhD @ranjankishu]

Teaming up with incredible colleagues, we carefully curated a collection of perspectives and research on the transformative impact of engineered medicines in cancer immunotherapy. #Cancer #Immunotherapy @sitcancer @yalepathology @YaleMed @FrontMedicine
https://t.co/86tjuUK3XP

[Mount Sinai Human Immune Monitoring Center (HIMC) @MountSinaiHIMC]

Exciting news! 📢HIMC has implemented @RareCyte Orion high-plex immunofluorescence imaging instrument to investigate the local tissuemicroenvironment! Check out the solid tumor tissue images for various immune infiltrates and CAR-T targets in Multiple myeloma 👇

[Science Magazine @ScienceMagazine]

In @SciSignal, researchers elucidate how the cytokine TNF-alpha—which is implicated in rheumatoid arthritis—reprograms the metabolism of #Tcells, suggesting this reprogramming is dysregulated during chronic inflammatory diseases. https://t.co/sSCoGk5IXI

[Science Magazine @ScienceMagazine]

The Human Immunome Project will probe thousands of immune variables in blood and tissue samples, likely creating the world’s largest and most comprehensive immunological database.

Learn more: https://t.co/jFSllhkC3l @NewsfromScience

[Miriam Merad, MD, PhD @MiriamMerad]

Very excited by our results @Nature showing that IL4R signaling is strongly enriched in myeloid cells that infiltrate mice and lung cancer lesions https://t.co/Nnjc7ue96y

[Science Magazine @ScienceMagazine]

A new probiotic-guided CAR-T platform uses engineered bacteria to infiltrate and produce synthetic antigen targets, enabling CAR-T cells to find, identify, and destroy tumor cells in situ.

📄: https://t.co/CVImaI5vWf
#SciencePerspective: https://t.co/myZn8Sddml

[Qin Yan, PhD @QinYan1]

I am delighted that DoD Breast Cancer Research Program highlighted our work on CECR2, an epgienetic regulator of #BreastCancerMetastasis, conducted in collaboration with @DavidRimm # Lajos Pusztai, #Jon Morrow # Mingzhu Yin. @yalepathology @YaleCancer
https://t.co/Dw8WfBmn2y

[Journal for ImmunoTherapy of Cancer @jitcancer]

New #JITC article: The landscape of MHC-presented phosphopeptides yields actionable shared tumor antigens for cancer immunotherapy across multiple HLA alleles https://t.co/Cgjg3b54rZ

[Nature Biomedical Engineering @natBME]

The September cover illustrates that the tagging of tumour cells with an amphiphilic ligand for a chimaeric antigen receptor on T cells allows for the universal redirection of the cells against solid tumours.

https://t.co/Q0wfz2k32o
https://t.co/1S9sR0NAg0 [Paper]

[Cell @CellCellPress]

In the latest issue! Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation https://t.co/Q0u1VYHCmg

[Yale Cancer Center @YaleCancer]

Kurt Schalper, MD, PhD, was recipient of the Best #Mentor Award at the 2023 @ASCO / @AACR Methods in Clinical Cancer Research Workshop last month. Congratulations, Dr. Schalper! #vailworkshop
@SmilowCancer @YaleMed @YNHH @yalepathology

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Strategies to therapeutically modulate cytokine action https://t.co/RuweH8Ecpx

This new review covers the biology of cytokines, properties of their receptors and how their signalling pathways could be controlled for therapeutic benefit, including by cytokine engineering

[Nature Portfolio @NaturePortfolio]

The results of a study in @Nature identify a pharmacological strategy for targeting epithelial-to-mesenchymal transition in cancer, opening up novel therapeutic interventions for anti-cancer therapy. https://t.co/jMEYKZWnNu

[Journal for ImmunoTherapy of Cancer @jitcancer]

Beginning next week! Applications for the 2024 Class of the #JITC Peer Review Mentorship Program will be collected Aug 8 - Sept 8, 2023. For more information, visit https://t.co/sPgW7KMLow

[Cancer Cell @Cancer_Cell]

Online Now: A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity https://t.co/2ilmjNgHuk