Excited to share our work studying the DRG sensory innervation of the colon! We found 5 subtypes of DRG neurons that innervate the colon with distinct morphologies, physiologic responses to distension, and behavioral effects. https://t.co/XSD77J0tLq
been thinking a lot about vaccine inequality lately — this piece is the result of working with NYT reporters across more than a dozen countries (and lots of U.S. states!) looking at who is eligible vs. who is actually being vaccinated https://t.co/rRMt8kIcFO
As always, @rsaxton_ doing beautiful structural work and then taking insights from the structure to stimulate likely important clinical therapies in the future. Congrats, Bobby! Excited to see what you’ll do next...
Very excited to share our work on IL-10 out today in @ScienceMagazine! We solved the cryo-EM structure of the IL-10 receptor complex and used it to design myeloid-selective IL-10 variants that uncouple its pro- and anti-inflammatory effects https://t.co/inApZbznWg
Thanks @DMSabatini! It was an honor to follow in the footsteps of so many talented female grad students... and to pass the torch along to the next generation!
A great day to point out that several fantastic women scientists, including @yasesancak, @rlwolfson, @XinGu0317, Lynne Chantranupong, and Shuyu Wang, have driven what is likely our most important work—nutrient-sensing by mTOR. #InternationalWomenDay2021
Beautiful work from @hankadel et al introducing a new technique for rapidly purifying melanosomes and an example of the amazing things you can discover with it! Looking forward to seeing what else you can find in melanosomes...
Excited to we debut MelanoIP, a new method for rapidly purifying melanosomes! With MelanoIP, we elucidate the function of MFSD12, a recently discovered pigmentation protein. https://t.co/933n6VSkGg
On my first day at the Whitehead, Angelika gave me her unvarnished view of me: I needed to be baptized and stop working on rapamycin. From that day on I was in awe of her honesty and brilliance and humor. She was our greatest scientist and human. Rest in peace my dear friend.
Check out @SSebastianChoi’s beautiful work identifying two parallel ascending pathways in the anterolateral tract that are necessary for conveying tactile and noxious information from the periphery to the lateral parabrachial nucleus. It was such a pleasure to contribute to this!
Finally out! Our work describing parallel ascending spinal pathways for affective touch and pain now out in @nature. Huge thanks to Koerber/Ross @decouvriez labs and Junichi now at @spinalcordgroup for awesome collaboration! and all other authors too! https://t.co/JjdQXWNS2f
Novel work from the @sokol_mdphd lab elucidating the role of sensory neurons triggering dendritic cell migration in the allergic response. Congrats @sokol_mdphd et al! Can’t wait to see what will follow
It's been an absolutely stellar week for the Sokol Lab! Our group’s first paper is now online at @ImmunityCP. In this paper @MdPerner@theILCguy & @XuepingZhu show that sensory neurons detect allergens and activate DCs to initiate allergic immunity. (1/x)
https://t.co/9qxGKFugJT
So great to put this out! Many years in the making. We used #CRISPR screens to find #mTORC1 regulators and clarified how #mitochondria "talk" to mTORC1. https://t.co/giLisIUK1F
Looking forward to presenting this paper at Ginty lab journal club today... special thanks to @jmvyasmdphd for sending me the paper literally minutes after it came out! https://t.co/S95s4nf5XI