Rajiv Trehan

@NIH MRSP Scholar '22-'25 - Predoctoral Fellow Greten Lab | @RWJMS ‘24 | @CWRU BME '19 | Tweets are my own

[Rajiv Trehan @RTMedEngineer]

@ShadinGhabra_MD @NatureComms Thank you Shadin! It was wonderful to collaborate on this and future projects!

[Rajiv Trehan @RTMedEngineer]

1/10
🚨 Excited to share our study in @NatureComms where we reveal how tumor-associated macrophage transdifferentiation predicts and promotes liver metastasis—a key mechanism driving immunotherapy resistance.
🔗 https://t.co/8wcnzhrppU

[Rajiv Trehan @RTMedEngineer]

10/10 Thank you to @dkstrepay @ShadinGhabra_MD @MartinAArhin @BenmebarekMr @TimGreten #CancerResearch #LiverMetastasis #ImmunoOncology #TumorImmunology @theNCI @NIH

[Rajiv Trehan @RTMedEngineer]

9/10 👉 This opens exciting opportunities: – Use the macrophage signature to stratify patients at high risk of liver mets – Target transdifferentiation pathways (SPP1, TGF-β, IL-6) to prevent liver colonization

[Rajiv Trehan @RTMedEngineer]

8/10 Our work suggests that the liver isn’t just a passive site for metastasis—it’s actively preconditioned by macrophage remodeling even before tumor cells arrive.

[Rajiv Trehan @RTMedEngineer]

2/10 Liver metastases are a major clinical challenge across many cancers. Despite abundant tumor-reactive T cells in the liver, these metastases often resist immune checkpoint blockade. Why?

[Reda Benmebarek @BenmebarekMr]

Excited to share our study on the treatment effect and underlying mechanism using a triple therapy of VEGF+PDL1+CTLA4 blockade in CCA, published today in @ImmunityCP👨‍🔬🥳

Article: https://t.co/Zm8g1NyLk2

A brief summary of the exciting science from @TimGreten lab below: (1/6)

[Laura Goff @drlauragoff]

Innovation grant to understand resistance to chemo immunotherapy in CCA…dream team! ⁦@theNCI⁩ ⁦@curecc⁩ ⁦@

[Rajiv Trehan @RTMedEngineer]

@jamaldonadoMD Congrats!

[Rajiv Trehan @RTMedEngineer]

@MaevePascoe @byrnebabybyrne3 @NIHBrainTumor Congrats!

[Cell @CellCellPress]

In the latest issue! Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin https://t.co/degUnXp9he

[Benjamin Ruf @BenniRuf]

Couldn't be more grateful to be part of this fantastic team effort with many friends and collaborators @matthias_bruhns @LichunMa @mrevsine @BenmebarekMr @DrHeinrichB @varuny_tunes @bengreen_MD @KCBSkope @RTMedEngineer @ruchinskas @mkss49 @XinWang77 and many more. (8/11)

[Benjamin Ruf @BenniRuf]

🥳🥳🥳Couldn't be happier to see our study on mucosal-associated invariant T (MAIT) cells in HCC published today in @CellCellPress.

Article: https://t.co/s7HEXLNN7U

Brief summary of this exciting collaborative work between @TimGreten lab and @claassenlab below (1/11):