ThorstenGnad

Former academic working on purines in brown fat and skm. now working for germany medicinal agency reviewing novel t2d and cdv drugs in Bonn, Germany

[ThorstenGnad @scheibendoc]

@nfldraftscout depressed

[ThorstenGnad @scheibendoc]

@Tonysmarkettips they probably manage to leave a hole at oline and safety 😞

[Dingchang Lin @DingchangLin]

🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
https://t.co/eVchPCiK6f

[ThorstenGnad @scheibendoc]

@DingchangLin @Peter_Aldiss @Nature Brilliant work!

[ThorstenGnad @scheibendoc]

@Coach_Yac E

[ThorstenGnad @scheibendoc]

@OurSf49ers only a 1 with the conplete absence of a running game

[ThorstenGnad @scheibendoc]

@NerdyCammy ;-) that's gold

[ThorstenGnad @scheibendoc]

@wearetherace 0

[The Roberts Lab @TheRobertsLab1]

Excited to share our new review in @NatRevDrugDisc covering ongoing efforts to therapeutically target chromatin remodelers focusing on SWI/SNF complexes. Congratulations to authors @HaydenMalone3 and Charlie! @stjudegraduate @stjuderesearch #swisnf (1/9) https://t.co/iE2HcC3CmO

[ThorstenGnad @scheibendoc]

@OdedRechavi @zenbrainest one of the most exciting papers i have read in ages! congratulations to the whole team!

[Oded Rechavi @OdedRechavi]

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇
https://t.co/I2j2pAel69

[GeroScience @GeroScienceAGE]

📢New Open🔓Access Article Alert
The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice by Charles W. Collinge & Alessandro Bartolomucci et al.
https://t.co/eab9Lpnp79
#frailty #SocialFrailtyIndex #biologicalage #socialdeterminantsofhealth #geroscience
#Progeria

[ThorstenGnad @scheibendoc]

@_b_meyer @BarteltLab nailed it!

[Daniel J Drucker @DanielJDrucker]

A new mode of action of sulfonylureas is proposed which is mediated via their interference with PPARγ phosphorylation rather than via classical PPARγ agonist activity at clinical concentrations @MolMetab https://t.co/LWpAusXDnU

[ThorstenGnad @scheibendoc]

@DagmarWachten @Kornfeld_JanW @NatMetabolism @TRR_BATenergy Congratulations! Amazing effort and beautiful insight into BAT regulation!

[Dagmar Wachten & lab @DagmarWachten]

Thrilled that our huge team effort with @Kornfeld_JanW is out in @NatMetabolism 🥳 supported by @TRR_BATenergy A huge thank you to all collaborators! If you want to know how a truncated AC3 isoform regulates #BAT function, have a look here https://t.co/sOZAersi2D

[NIDDK @NIDDKgov]

Congrats to Dr. Jürgen Wess, Section Chief of Molecular Signaling in NIDDK’s Laboratory of Bioorganic Chemistry, for being elected a 2023 @aaas Fellow for his distinguished contributions to molecular and translational pharmacology. https://t.co/oCX3K9yZni

[Nature Cell Biology @NatureCellBio]

💫NEW: @labpfeifer, @LaiaSalisa & co show that, in #preadipocytes, #EPAC1 enhances brown #AdiposeTissue growth and the function of #ThermogenicFat in obesogenic conditions. EPAC1 activation induces human brown adipocyte proliferation and differentiation.
https://t.co/lRvxOYXWNJ

[ThorstenGnad @scheibendoc]

@LaiaSalisa @NatureCellBio Excellent work Laia shedding light on cAMP signalling beyond PKA! Congratulations!

[Laia Reverte-Salisa @LaiaSalisa]

Happy to finally share our work on the role of EPAC1 in brown adipose tissue @NatureCellBio
https://t.co/h6WRBzViCU