🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
https://t.co/eVchPCiK6f
Excited to share our new review in @NatRevDrugDisc covering ongoing efforts to therapeutically target chromatin remodelers focusing on SWI/SNF complexes. Congratulations to authors @HaydenMalone3 and Charlie! @stjudegraduate@stjuderesearch#swisnf (1/9) https://t.co/iE2HcC3CmO
It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇
https://t.co/I2j2pAel69
📢New Open🔓Access Article Alert
The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice by Charles W. Collinge & Alessandro Bartolomucci et al.
https://t.co/eab9Lpnp79
#frailty #SocialFrailtyIndex #biologicalage #socialdeterminantsofhealth #geroscience
#Progeria
A new mode of action of sulfonylureas is proposed which is mediated via their interference with PPARγ phosphorylation rather than via classical PPARγ agonist activity at clinical concentrations @MolMetab https://t.co/LWpAusXDnU
Thrilled that our huge team effort with @Kornfeld_JanW is out in @NatMetabolism 🥳 supported by @TRR_BATenergy A huge thank you to all collaborators! If you want to know how a truncated AC3 isoform regulates #BAT function, have a look here https://t.co/sOZAersi2D
Congrats to Dr. Jürgen Wess, Section Chief of Molecular Signaling in NIDDK’s Laboratory of Bioorganic Chemistry, for being elected a 2023 @aaas Fellow for his distinguished contributions to molecular and translational pharmacology. https://t.co/oCX3K9yZni