Richard G. James

Principal investigator at Seattle Children's. We study B cell development, immunological disease and response to therapy.

[Richard G. James @ScienceRicker]

Thanks to the amazing Iana Meitlis who is in UW Med school, Eric Allenspach, Andrew Snow and Dave Rawlings. These methods were based on work by @jshendure, @lea_starita, @TheNobleDust

[Richard G. James @ScienceRicker]

@bebiopharma @nih_nhlbi This was a fantastic talk from David Young and the Dunbar group and Be Bio. The demonstration that ex vivo derived B cells engraft into lymphoid organs without precondition in non-human primates is a huge step forward. Congratulations!!

[dinodicarlo @dinodicarlo]

@slavov_n @ScienceMagazine Please take a look at this manuscript in collaboration with @ScienceRicker that also shows one should not make an assumption that transcript # is correlated to secretion of a protein. https://t.co/nRYJpNt1Ru

[Be Biopharma @bebiopharma]

New research published in @NatureComms from our co-founders Drs. @ScienceRicker and David Rawlings from @seattlechildren shows robust protein production and long-term engraftment of engineered plasma B cells. https://t.co/WHXtwx3H8G #BeBio #SCRI #Research #BCells

[King L Hung @kinglhung]

Very happy to see the full story out finally. We had been sitting on some of these exciting findings since 2017! (6/6)

[Peter Smibert @psmibert]

A really cool application of Partillion Biosciences and @10xGenomics technologies to measure secreted proteins together with single cell gene expression.

[Longwood Fund @LongwoodFund]

Congratulations to @bebiopharma on the Series B! This Longwood-founded company is making progress in developing a new class of cellular medicines to help patients.

[Richard G. James @ScienceRicker]

@amermathsoc @UW This is so cool! And well deserved!

[American Mathematical Society @amermathsoc]

Bianca Viray, a professor @UW, has been awarded the AMS Joan and Joseph Birman Fellowship for Women Scholars for the 2022–2023 academic year. An arithmetic geometer, Viray researches rational points on varieties.

➡ https://t.co/SprLitjLzZ

[Brotman Baty @BrotmanBaty]

Join our team!
DIRECTOR OF MUTATIONAL SCANNING
This person will lead a team to help bring mutational scanning methods to production scale. Terrific job opportunity with @JShendure @lea_starita
Details and how to apply here: https://t.co/xL9DnP14VF

[Balazs Lab @BalazsLab]

Until the pre-print posts, I figured I would put together a thread for those who want to see the data. Many thanks to @wilfredo_nk, @kstdenis29, @EvanCLam, @adamnitido, @NaranbhaiVivek who have been up at all hours of the night both at the bench and writing the paper!

1/16

[King L Hung @kinglhung]

Today we release in @biorxivpreprint a method for isolating megabase-sized, oncogenic extrachromosomal DNA from human cancer cells. A collaboration with @HowardYChang, @Jens_Luebeck, @RaeisiSiavash, Vineet Bafna, @mischellab and others. (1/n) https://t.co/S4tCXMLJui

[King L Hung @kinglhung]

Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) https://t.co/FGMYDEfUmx

[Be Biopharma @bebiopharma]

B cells are nature’s medicine factories built to unleash a variety of therapeutic applications. Hear our scientific co-founders, Richard James (@ScienceRicker) & David Rawlings describe the incredible versatility of B cells.
https://t.co/wpFUN76sYs

[(Fred)erick Matsen @ematsen]

Introducing NextTrevor, an open-source project to harness publicly available images of @trvrb. We provide a continually-updated view of @trvrb's evolution alongside powerful analytic tools. Our goal is to aid understanding and improve response to changes in his appearance.

[Lea Starita @lea_starita]

Congrats to the hubs, @ScienceRicker, for cofounding @bebiopharma, over zoom, while simultaneously home schooling 6th grade! Exciting technology for the sustained delivery of protein therapeutics. Read more here ⬇️

[Sanjay Srivatsan @SRsrivatsan]

Check out our paper —>

[Richard G. James @ScienceRicker]

Your work started @kinglhung - we are super excited to keep it moving forward!

[King L Hung @kinglhung]

So glad to see that this is gaining traction!

[Richard G. James @ScienceRicker]

@_mattrich Thanks Matt! We are super excited

[Longwood Fund @LongwoodFund]

Thanks for featuring @bebiopharma Longwood-founded #celltherapy #newco https://t.co/9SgXaEy0jb

[Richard G. James @ScienceRicker]

Excited to share our functional data that has helped classify VUS associated with immune dysregulation at #CIS2021 - what a great meeting! Check it out