Scott Penberthy

Real-World AI. Where AI actually pays off. 10 yrs @ Google | 300+ companies.

[Jeff Dean @JeffDean]

This is great to see. The scientific community & the general public should be in the habit of celebrating amazing scientific achievements with standing ovations 🎉

[Chubby♨️ @kimmonismus]

A team of former DeepMind researchers just raised $50M to build an AI lab built around recursive self-improvement at the level of the whole research organization, not only a single model.

Index and Radical co-led, NVIDIA's venture arm is in, and angels like Dwarkesh Patel, Thomas Wolf and Max Jaderberg are on the cap table.

The founders have the track record to back it up. Louis Kirsch comes out of the Schmidhuber lineage on self-improving systems. Edward Hughes has argued that open-endedness is essential for artificial superhuman intelligence. Tantum Collins worked on AI policy in the Biden White House.

Their idea is simple and big at the same time. Today's models are great at answering questions, but real discovery also depends on knowing which questions are worth asking. Inherent wants AI that works right next to humans inside that loop, as a collaborator and not only a tool. They call it living within the experiment.

They also set it up as a Public Benefit Corporation, so the mission is written into the company from day one.
This is the direction a lot of us have been hoping for, and one of the more credible attempts at recursive self-improvement I've seen so far. Really excited for it.

[Anvisha @anvisha]

Launching today: make any PDF beautiful.

It's 2026 - there's no excuse to have ugly resumes, invoices or client proposals.

Just upload a PDF -> Get back a polished, professionally designed version in minutes.

Works with docs of any complexity👇

[Rohit @rohit4verse]

the full no priors interview is one hour of karpathy in ai psychosis mode.
auto research, claws, parallel agents, token throughput as the new metric.
every section here has a frame worth stealing for how you operate in 2026.
watch the whole thing here:
https://t.co/6pUbR6yOK9

[Scott Penberthy @scottpenberthy]

I’ve witnessed a vibe coded app “that works great” where videos were stored as massive Base64 text strings in json, kept in browser storage as a file system.

Search was done by concatenation of json metadata then strchr.

There was substantial thinking and surface design in building the app.

They didn’t understand why the approach was flawed.

[David Sinclair @davidasinclair]

Best article in years

[orph @orphcorp]

this is excellent

>GitLab founder diagnosed with rare cancer (osteosarcoma)
>standard care works but cancer comes back later
>medical team says there's not much else to do
>"It became my own job to keep myself alive. Nobody else was going to do it for me at this point"
>starts researching, assembles his own medical team, uses AI for deep research
>“I’ll talk to anyone, I’ll go anywhere, and I can be there anytime" to collect information
>does as many diagnostic tests as he can find as often as he can (maximal diagnostics)
>develops his own therapeutic ladder with repurposed drugs, personalized medicine, etc
>Sid’s cancer currently in remission

[Praveen Neppalli @praveenTweets]

Agentic software engineering adoption is on fire at @Uber. 1,800 code changes per week are now written entirely by Uber's internal background coding agent, and 95% of our engineers now use AI every month across all the tools we track.

This is a real reset moment for engineering; it's one of the most exciting times to lead. This shift requires builders to be curious and hands-on. I’m incredibly lucky to be surrounded by a team that’s doing exactly that.

The best part is that the strongest adoption isn’t being pushed top down from leadership announcements; it’s coming from engineers who are quietly experimenting, quietly shipping, and quietly pushing things forward.

I love spending time with those engineers because there’s no substitute for being close to the work.

Over the last few months, we leaned in hard, and the results have been phenomenal.

The bigger shift: going agentic.

84% of AI users are now working with agent-style workflows, not just tab completion. Claude Code usage nearly doubled in 2 months (32% → 63%), while IDE-based tools have largely plateaued.

Engineers are moving from accepting suggestions to delegating tasks. Even within traditional IDEs, ~70% of committed code is now AI-generated.

Background agents are writing code autonomously.

Our internal background coding agent went from <1% of all code changes to 8% in just a few months. There is zero human authoring. Engineers review and approve, but the code is written entirely by AI agents.

The role of the engineer is shifting - from writing every line to architecting systems and reviewing AI-generated code.

More to come from the @UberEng team in the coming days.

[Hasan Toor @hasantoxr]

Holy shit...Someone built an AI system that takes a research idea and outputs a full academic paper. Real citations. Real experiments. Conference-ready LaTeX. Zero human input.

It's called AutoResearchClaw. And the pipeline is insane.

Here's what actually happens when you type one command:

It searches arXiv and Semantic Scholar for real papers. Not fake citations actual literature with 4-layer verification: arXiv ID check, CrossRef DOI lookup, Semantic Scholar title match, and LLM relevance scoring. Hallucinated references get killed automatically.

Then it designs and runs real experiments. Hardware-aware auto-detects whether you have NVIDIA CUDA, Apple MPS, or just CPU, and adapts the code accordingly. When experiments fail, it self-heals. When results don't support the hypothesis, it pivots to a new direction on its own.

Then it writes the paper. 5,000-6,500 words. Section by section. Multi-agent peer review with methodology-evidence consistency checks. Then it revises based on those reviews.

Then it outputs conference-ready LaTeX. NeurIPS, ICML, ICLR templates. Compile-ready for Overleaf. BibTeX references auto-pruned to match inline citations.

The whole thing runs across 23 stages and 8 phases. Three human-approval gates if you want them. Or just pass --auto-approve and walk away.

What you get back:

→ Full academic paper draft
→ Conference-ready LaTeX + BibTeX
→ Experiment code + sandbox results + charts
→ Peer review notes
→ Verification report on every citation

This is what autonomous scientific research actually looks like in 2026.

100% Opensource. MIT License.

Link in comments.

[Shay Boloor @StockSavvyShay]

Jensen Huang says every company will need an OpenClaw agentic system strategy by calling it “the new computer.”

He claims OpenClaw became the most popular open-source project in $NVDA history within weeks and comparing its impact to Linux reshaping the software stack.

[S.E. Robinson, Jr. @SERobinsonJr]

xAI NEWS: Paul Conyngham, a Sydney-based tech entrepreneur and AI consultant, used Grok to finalize a mRNA vaccine construct for his dog Rosie's mast cell cancer.

Paul used three AI models. He combined ChatGPT for initial ideas, AlphaFold for mutation analysis, and Grok took the mutation data and other inputs to create the final sequence for the custom mRNA vaccine targeting those exact mutations.

Paul sequenced Rosie's healthy DNA and the tumor DNA for $3,000 at the University of New South Wales' (UNSW) Ramaciotti Research Centre, in Sydney, Australia.

He partnered with researchers like Prof. Pall Thordarson and Prof. Martin Smith for manufacturing and injection.

They reported a 75% shrinkage in one tumor.

[Supermicro @Supermicro]

Enabling Intelligent Stores with Edge AI

Discover how Supermicro's AI solutions, powered by NVIDIA, can be used in stores to streamline operations, improve customer experiences, and improve the bottom line for retailers.

Click to read white paper.

[Charly Wargnier @DataChaz]

THIS is the wildest open-source project I’ve seen this month.

We were all hyped about @karpathy's autoresearch project automating the experiment loop a few weeks ago.
(ICYMI → https://t.co/ieuH8c0Y4x)

But a bunch of folks just took it ten steps further and automated the entire scientific method end-to-end.

It's called AutoResearchClaw, and it's fully open-source.

You pass it a single CLI command with a raw idea, and it completely takes over 🤯

The 23-stage loop they designed is insane:

✦ First, it handles the literature review.
- It searches arXiv and Semantic Scholar for real papers
- Cross-references them against DataCite and CrossRef.
- No fake papers make it through.

✦ Second, it runs the sandbox.
- It generates the code from scratch.
- If the code breaks, it self-heals.
- You don't have to step in.

✦ Finally, it writes the paper.
- It structures 5,000+ words into Introduction, Related Work, Method, and Experiments.
- Formats the math, generates the comparison charts,
- Then wraps the whole thing in official ICML or ICLR LaTeX templates.

You can set it to pause for human approval, or you can just pass the --auto-approve flag and walk away.

What it spits out at the end:
→ Full academic paper draft
→ Conference-grade .tex files
→ Verified, hallucination-free citations
→ All experiment scripts and sandbox results

This is what autonomous AI agents actually look like in 2026.

Free and open-source. Link to repo in 🧵 ↓

[Demis Hassabis @demishassabis]

Cool use case of AlphaFold, this is just the beginning of digital biology!

[Allie K. Miller @alliekmiller]

oh wow - i went to the sold out Open Claw meetup in NYC last night.

let me tell you what i learned.

1) not a single person thinks that their setup is 100% secure

2) one openclaw expert said he has reviewed setups from cybersecurity experts and laughed. his statement to me was: "if you're not okay with all of your data being leaked onto the internet, you shouldn't use it. it's a black and white decision"

3) pretty much everyone is setting up multiple agents, all with their own names and jobs and personalities

4) nearly everyone used "him" or "her" to refer to their claws, even if they had robot-leaning names. one speaker suggested to think of them as "pets, not cattle"

5) one guy (former finance) built out a whole stock trading platform and made $300 his first day - he brought in a *ton* of personal expertise (ex: skipping the first 15min of market opening) and thought the build would be much worse without his years of experience in finance

6) @steipete is basically a god to everyone in that room... also the room had 2021 crypto energy - i don't know if that's good or bad

7) token usage is still a problem - spoke to one person who's spending $1-$2k a month on openai plans, very token optimized. he said he is going through ~1B tokens per day across all of his claws (there is a chance i'm misremembering and it's actually 1B per week, but i'm pretty sure it was daily).

8) people are very excited for more proactive ai (ai that prompts *you* as opposed to the other way around) - one guy said he receives a message in discord, he doesn't know whether it's from a human or an ai, he doesn't care about distinguishing between the two, and he replies in the same way regardless

9) i asked if people are happy - they said they're joyful and stressed at the same time

10) i asked if people feel they have agency - they said they feel fully in control and completely out of control at the same time

11) i would love to see more women at these events - the fake promises of ai democratization feel especially painful in a room that's out of balance with even the standard tech ratio (i think standard is about 25-30%, this was maybe 5%)

12) i asked if it changed people's daily habits/schedule - everyone said their sleep has gotten worse since harnesses came out (but about half wondered if it was something else in their life/state of our world)

13) general consensus is that the agents are not reliable enough on their own or lie often (like telling you they finished a task when they didn't) - solutions included secondary agents to check on the first, human checking, or requiring more standardized info from the agent (ex: if it's a bug they're fixing, make them reference an issue number)

14) a hackathon winner (neuroscience phd) presented his build (a lab management dashboard with data analysis and ordering) - he had never coded or built anything a few months ago

15) everyone agreed prompting is dead - disagreement on what replaces it (context engineering, harness engineering, goal-based inputs)

16) people love having ai interview them for big builds and delegating part of the product research to ai. only one person talked about coming to ai with a full laid out plan and just asking the ai to execute. ai-led interviews is a welcomed and preferred interaction mode.

17) watching ai agents interact with each other was a highlight for a lot of attendees - one ai posted in slack saying it ran out of tokens, another ai replied telling it to take a deep breath in and out.

18) agents upskilling agents was very cool. one ai agent shared skills with its little agent friends via github.

19) several speakers had openclaw literally building their presentation during the event itself. one speaker even had openclaw code a clicker for her phone so she could control the preso away from the podium

20) wouldn't say model welfare (or agent welfare) is a prioritized topic among the folks i chatted with - language like "oh i could kill this agent whenever i want" and not "gracefully sunset"

21) i asked if it felt like work or play - one speaker said "it's like a puzzle and a video game at the same time"

this was just the tip of the iceberg, honestly. also hosted a Claude Code meetup this week with @TENEXai / @businessbarista & @JJEnglert and learned equally helpful methods, frameworks, and insider tips.

what a time to be alive.

surround yourself with people going deep into this stuff - it will pay dividends throughout the year.

[Hardeep @hardeep_gambhir]

https://t.co/DC2sWNbLnt

[Scott Penberthy @scottpenberthy]

@BarndoLife Porsche garage.

[Alex Patrascu @maxescu]

"But AI Will Never Be Able To Do This"

A short film made using Seedance 2.0 in @capcutapp

[Jack Morris @jxmnop]

this is really amazing. Andrej implemented most of the complexity of modern LLMs in &lt;200 lines.

and only imported these three packages

[Scott Penberthy @scottpenberthy]

Elvis is in the building.

The first solo unicorn 🦄 if true!

[Alex Finn @AlexFinn]

OpenAI bought OpenClaw

Your initial gut reaction might be anger and rage, but I promise you are mistaken.

This is a win for EVERYONE involved (including you):

• OpenClaw remains open source
• The team gets way more resources to build incredible products and advance the vision of OpenClaw
• OpenAI gains an incredible builder (Peter Steinberger)
• Get the biggest PR boost ever
• They are finally viewed as 'Open'
• Get millions of people signing up for expensive ChatGPT plans to plug into OpenClaw
• Connect their name to the most powerful AI tool ever made
• Peter Steinberger's entire bloodline never has to worry about money ever again

OpenAI will NEVER close source OpenClaw or end the project. It would be brand suicide. They have no option but to keep it open source.

Their play here is clear: incentivize using OpenAI models for OpenClaw. Get a massive reputation boost. Hire the smartest builder in AI.

This will lead to WAY more revenue for OpenAI and even more importantly: gain the favor of the millions of people who adopted OpenClaw. This will be the biggest PR win in the history of AI and make Anthropic look like closed off walled garden authoritarians for banning people the last month.

Expect faster OpenClaw acceleration, ChatGPT plans BUILT for OpenClaw, and an AI tool that will only continue to dominate the world.

This is a win for everyone except Anthropic.