Shatha AbuHammad

Scientist @danafarber @harvardmed 🧬🔬🧪

[David R. Liu @davidrliu]

In a major milestone for science, for medicine, and for patients, the world’s first CRISPR drug has been approved in the UK.
“A new treatment for sickle-cell disease and transfusion-dependent β-thalassemia has been authorised by the Medicines and Healthcare products Regulatory Agency (MHRA) for patients aged 12 and over after a rigorous assessment of its safety, quality and effectiveness.”
Congratulations to the many scientists, doctors, patients, and industry leaders who made this development possible.🍻
https://t.co/pUL956YsG3

[Shatha AbuHammad @shathaabuhammad]

@Nancy_T_S @McArthurLab So great seeing you again Nancy! Best of luck in New York!

[Stuart Schreiber @SchreiberStuart]

Screening preselected presenter (FKBP12) and target (mTOR) proteins to discover molecular glues exemplified by the discovery of a synthetic mimic of rapamycin https://t.co/PXtS3Mjm2h

[Ryan Potts @pottslab]

🔥🔥 Exciting developments on novel quality control mechanisms by the UBR5 E3 ubiquitin ligases. Potential opportunity for molecular glue discovery to take on some challenging transcription factors. Congrats @RapeLab @LabThoma et al.

[Guillaume Laconde @Glaconde34]

Development of DNA Aptamer-Based PROTACs That Degrade the Estrogen Receptor https://t.co/H7t5AwEYzr

[IRB Barcelona @IRBBarcelona]

🎯Targeted protein degradation as a therapeutic strategy: the focus of the 39th #BarcelonaBioMed Conference.

🗣The @FundacionBBVA & #IRBBarcelona are bringing together in #Barcelona more than 150 scientists from 🌏all over the world to discuss the latest advances in this promising field.

➡️https://t.co/AzxQquWd7a

#TPD

[Mark Dawson @MAF_Dawson]

The career question I get asked the most is “why did I become a Physician-Scientist” - too often I give a vanilla answer to this - some colleagues have a Eureka moment- for me it was uncertainty, failure & extraordinary mentorship that set me on my journey https://t.co/RpTHgDuwCM

[Cees Dekker @cees_dekker]

Today, we publish a paper in @Nature that describes how the DNA-binding protein CTCF regulates DNA loop formation by cohesin.

This is a collaboration with Jan-Michael Peters' lab at @IMPvienna, greatly led by 1st authors Iain Davidson (Vienna) & @RomanBarth2 (CDlab at Delft)
1/

[Stuart Schreiber @SchreiberStuart]

How can you uncover novel biological mechanisms beginning with observations from human genetics? Read this:
Large-scale variant-to-function mapping in primary hematopoietic stem and progenitor cells from @TheXavierLab
https://t.co/kIyMN0e3gZ

[Ingo Hartung @HartungIngo]

More fireworks after 6 pm at #AACR23: #CICR townhall with 3 awesome talks about molecular glue degraders. Michael Rapé (@RapeLab), Riccardo Sabatini (@OrionisBio) & Mary Matyskiela (@neomorphinc). Chaired by Ben Ebert (@DFCI_ChemBio). Glueing everybody to their seats. @AACR #TPD

[The Scientist @TheScientistLLC]

A kill switch from @ChoudharyLab uses molecular glue to “shred” Cas9 and remove it from cells to control CRISPR editing, as described in a @biorxivpreprint, @IEmSteinmark reports. @broadinstitute @ESontheimerLab @theMaxwellLab @averyxaugust https://t.co/xYV6tgnC0b

[Stuart Schreiber @SchreiberStuart]

Looking forward to digging into this chemoproteomics resource that appears to have potential for multiple uses

[Stuart Schreiber @SchreiberStuart]

2/2 Highlighted paper is from Jordi Juárez-Jiménez and team and can be found here: https://t.co/M63Po7lUFj

[Stuart Schreiber @SchreiberStuart]

1/2. Lots of mysteries surrounding glue mechanisms, so its nice to see hydrophobic shielding of hydrogen bonds highlighted here by @Dereklowe. I'll bet there will be other surprises uncovered in the future.

https://t.co/K3NpIJ5GXL

[Chief Executive Officer VCCC Alliance @Prof_G_McArthur]

Front line role of our leading cancer researchers at #AACR23 in tackling one of cancers holy grails - targeting the RAS oncogene @bensolomon1 #JayeshDesai https://t.co/GgTUCXTK3p

[Nature Reviews Genetics @NatureRevGenet]

From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo https://t.co/9kX2KTGWDH #Review by @DAndergassen and @Noncodarnia
@TU_Muenchen @CUBoulder

[Nature Reviews Molecular Cell Biology @NatRevMCB]

Now Online Cellular origins of dsRNA, their recognition and consequences https://t.co/X0Jk9rtqCe

[Vishal Navani, MD @navstruck]

🧵Grateful to share our work @JAMAOnc @DrDanielHeng outlining the rapid pace of change in advanced #kidneycancer #renalcellcarcinoma. A brief tweetorial. Combination approaches, IOIO and IO/VEGF have changed the paradigm for patients...1/4

https://t.co/d5XWYO4brc

[Dana-Farber News @DanaFarberNews]

For the first time, the @US_FDA has approved an #immunotherapy drug given after surgery for certain patients with #kidneycancer. The approval of adjuvant pembrolizumab was based on clinical testing led by Dana-Farber's Toni Choueiri, MD (@DrChoueiri): https://t.co/VxFB16NUN8

[Nature Reviews Genetics @NatureRevGenet]

NON-CODING RNA: Getting organized with non-coding RNAs https://t.co/Rn9dZBpp1u #ResearchHighlight