Simon Widmer

Systems Bio PhD Student at ETHZ, Interested in Signaling and Proteomics

[Jacob Hanimann @JHanimann]

Ever wondered what other people think about the paper you’re reading? Me too. So for the last year I’ve been building a Chrome extension that lets you comment on any paper, on Nature, PubMed, or arXiv. It’s linked via DOI, so the thread follows the paper wherever you find it 🧵

[nature @Nature]

Nature research paper: Multimodal cell maps as a foundation for structural and functional genomics

https://t.co/PmRqUuJzbP

[Prof. Nikolai Slavov @slavov_n]

At the sunset of 2024, I feel grateful for the wonderful things it brought us.
(yes, not all is wonderful)

I had much fun working with colleagues at @slavovLab & @ParallelSqTech!

A highlight includes alternate RNA decoding: https://t.co/2FpwXRznsj

What did 2024 bring you?

[Slavov Laboratory @slavovLab]

We report many proteins not predicted by the genetic code.

They are stable & abundant O( 10³ ) copies / cell.

Generative mechanisms include codon-anticodon mismatches & RNA modifications.

Their abundance depends on codon frequency & protein stability.

https://t.co/lAxvulC4zx

[Prof. Nikolai Slavov @slavov_n]

We first saw evidence for this ~ 2019.
We were super surprised & skeptical.

After 5 years of quintuple cross-validation, we feel confident to share with the world.

[Snijder Lab @snijderlab]

#Tweetorial for our paper in @ScienceMagazine

It's still largely unknown how naïve T cells decide to become either effector or memory T cells during viral infection. We show that these decisions are built into the cellular architecture of our T cells. 1/9
https://t.co/yOQgVaPgot

[Pedro Beltrao @pedrobeltrao]

We have an open postdoc position in the area of protein structural bioinformatics. Areas of interest include proteome-wide models, variant effect prediction, molecular evolution, allosteric regulation, protein/drug design. Deadline 20th July https://t.co/K43VYDVbwI

[Slavov Laboratory @slavovLab]

We report dynamic changes in protein covariation across single cells undergoing EMT.

These protein correlation dynamics are intrinsic to single cells but not reflected in population averages.

A new 🪟 towards cell transitions.

https://t.co/vEC6WySzza

[Barack Obama @BarackObama]

Fourteen years ago today, I signed the Affordable Care Act into law.

Afterwards, one Republican member of the House called the ACA the “most dangerous piece of legislation ever passed in Congress.” Another predicted the country would “never recover from it.”

But then something else happened: it actually worked.

[Parallel Squared Technology Institute (PTI) @ParallelSqTech]

Are you a mass spectrometrist excited about working with the most cutting-edge instruments for single-cell analysis? Consider joining our team of enthusiastic scientists as we aim to tackle questions related to Alzheimer’s Disease and aging! https://t.co/tDyrVi2J7g

[Prof. Nikolai Slavov @slavov_n]

Next Tue, I'll present at the @MITBiology departmental seminar.

I'll include results that fundamentally altered my view of the proteome.

It will be the first public presentation of surprising results that @slavovLab team has been testing for years.

https://t.co/47evkDKoaj

[D-CHAB @ETH_DCHAB]

Yamauchi @YamauchiLab presenting his #SARS -CoV-2 co-receptor study which was EU project of the month in Autumn 2020 and his more recent research on virus-inspired protein cages for cellular uptake to facilitate payload delivery in cells.

[Slavov Laboratory @slavovLab]

Our group will be represented at the @nuclearomics_23 by @_JasonDerks.

Jason will present his research on the control of protein transport at the resolution of single nuclei.

[CERN @CERN]

Today, CERN introduced its new science centre to representatives from Member and Associate Member States, the President of the Swiss Confederation, partners in research and outreach, and donors to the Science Gateway Project.

Watch this video for some of today’s best moments.👇

[Marc van Oostrum @Marc_vOo]

Come join us at the intersection where synaptic proteomes meet systems neuroscience!

📢 please RT!

[CERN @CERN]

What happens if you drop an anti-apple?

In a paper published today in @Nature, the ALPHA collaboration at CERN’s Antimatter Factory shows that, within the precision of their experiment, atoms of antihydrogen – a positron orbiting an antiproton – fall to Earth in the same way as their matter equivalents.

This result is a milestone in the study of the properties and behaviour of antimatter.

Find out more: https://t.co/C7DYs02nln

[Slavov Laboratory @slavovLab]

Andrew Leduc @_AndrewLeduc will present at the monthly meeting of the Single Cell Club.

Join the meeting to learn about single-cell methods that Andrew introduced and his latest research!

More info at: https://t.co/tUdQ8h0ZT9

[Emma Slack #IStandWithUkraine @Slack1Emma]

Also find @NCCRMicrobiomes at the Science cafe in the Alumni Lounge:
„Warum wir ohne Mikroben nicht leben können„
With Wolf-Dietrich Hardt, Jan van der Meer and me (auf Deutsch!).
https://t.co/T7KQPfgdnO
15:00, Sept 2nd

[Department of Quantitative Biomedicine @DQBM_uzh]

Join us at #Scientifica23 and become a cancer and brain researcher for an hour! Get your ticket for our lab tour on Saturday, 2 September: 12-13h/14-15h/16-17h on Campus Irchel @uzh_science and immerse yourself in the @bodenmillerlab and @polymenidoulab!

https://t.co/RKMegY74aD

[Andrew Leduc @_AndrewLeduc]

Great to see our work out on circadian rhythm in pancreatic Beta-cell maturation! Fun to work with @JuanAlvarezDom and see the work he’s doing

This was one of first big data set we prepared with nPOP, even before the @GenomeBiology manuscript :)