Our article on human cis- and trans- gene regulatory evolution is out!
TLDR; trans-environment impacts the functional genome divergence between species. Cis-DNA doesn't work alone.
Objectively cool and incredible scientists made this— @hansen_tylerj, @Hodges_Lab & @capra_lab
🎉Thrilled to announce that I'm joining @UTexasNutrition as Assistant Prof! 🤩 Grateful to mentors @NadavAhituv & Hei Sook Sul for their amazing support. Ready for a new chapter in research & teaching. Recruiting now at https://t.co/UGk1dHMpZW. Hook 'em Horns! #UTAustin
Trans gene regulation contributes to species divergence more often than you think!
Check out our latest work dissecting the genetic mechanisms of human and rhesus macaque gene regulatory divergence with @hansen_tylerj, @Hodges_Lab and @capra_lab
https://t.co/HVpeq2L3M1
What else? Trans-regulatory divergence results from changes in cell-signaling and transcription factor gene expression.
In some cases, cis-divergence upstream these key genes contributes to trans-divergence, illustrating the genetic basis of trans-effects.
How does human enhancer DNA evolve?
Ancient core & younger DNA can combine to form a biochemically active substrate! Distinct TF binding, stronger purifying selection, less common variation hallmark cores v. young DNA. Check out @capra_lab's new work👇
https://t.co/tHGR9Pcjaz
We are hiring! Multiple funded postdoctoral positions are available on projects at the intersection of bioinformatics, evolution, genetics, and electronic health records. Please share!
https://t.co/oToKR57ntO
We presented new work on cis and trans gene regulatory evolution at #cshlsysbio from @Hodges_Lab@capra_lab. As @Tyler_Hansen_VU said, it was great to meet people who do genomics and speak our language. We've got fresh inspiration after seeing such cool science. Back to work!
Ever wonder what the #3Dgenome folding🔺of a Neanderthal looked like?! Could it hold any clues as to where and why we have DNA 🧬and trait differences?
Check out our @capra_lab, Pollard lab & @gfudenberg lab collaboration @biorxivpreprint https://t.co/wec0qZiFWy
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New work w/ @capra_lab! Human enhancers can have multiple sequence ancestors. We show ancient core sequences integrated w/ younger derived sequences that bind unique TFs, are under less constraint, and link to increased genetic, gene expression variation. https://t.co/NQw1tqFqQW
Excited to share our latest work with an amazing team, @ChazinWalter@alexmblee and @ZacNagel lab, on improving tumor #VUS interpretation with an active learning strategy: https://t.co/JO3Y3aWEaM
Reminder to self (and others who it might help)! When creating a new @anacondainc 🐍environment, add some basic fonts so that your @matplotlib (or other) plots don't have Deja Vu Sans anymore!!
#boycottDejaVuSans
Tutorial here (thx @nekton4plankton): https://t.co/obm0qiDU3O
I’m so excited to finally share my PhD work!! Here we developed a new biochemical approach to study fork reversal and nascent strand degradation. We uncover that uncoupled replication forks cause fork reversal and multiple degradation events without evicting the replisome. 🧬🐸
New paper by graduate student Souhrid Mukherjee @AJHGNews! We use machine learning to predict disease gene pairs (DiGePred) to aid in the evaluation of patients with rare disease @VandyBioGrad @VUMCgenetics @UCSF_BCHSI@UCSF_Epibiostat@UDNconnect https://t.co/41o417hUdm
Woohoo 🎉! Our @capra_lab paper on how Neanderthal ancestry contributes to the heritability of over 400 traits made it to @NatureComms . Check it out!! Tweetorial soon to come.