Sarah Fong

Genetics. Evolution. Gene regulation.

[Sarah Fong @slifong]

https://t.co/zWx7SxYceD

[Sarah Fong @slifong]

Our article on human cis- and trans- gene regulatory evolution is out!

TLDR; trans-environment impacts the functional genome divergence between species. Cis-DNA doesn't work alone.

Objectively cool and incredible scientists made this— @hansen_tylerj, @Hodges_Lab & @capra_lab

[Hai Nguyen @pnguyen_hai]

🎉Thrilled to announce that I'm joining @UTexasNutrition as Assistant Prof! 🤩 Grateful to mentors @NadavAhituv & Hei Sook Sul for their amazing support. Ready for a new chapter in research & teaching. Recruiting now at https://t.co/UGk1dHMpZW. Hook 'em Horns! #UTAustin

[Sarah Fong @slifong]

Finally, we explore how underlying mechanisms of regulatory divergence reveals new insights into human-specific evolution and human health. Neat!

[Sarah Fong @slifong]

Trans gene regulation contributes to species divergence more often than you think!

Check out our latest work dissecting the genetic mechanisms of human and rhesus macaque gene regulatory divergence with @hansen_tylerj, @Hodges_Lab and @capra_lab
https://t.co/HVpeq2L3M1

[Sarah Fong @slifong]

What else? Trans-regulatory divergence results from changes in cell-signaling and transcription factor gene expression.

In some cases, cis-divergence upstream these key genes contributes to trans-divergence, illustrating the genetic basis of trans-effects.

[Sarah Fong @slifong]

How does human enhancer DNA evolve?
Ancient core & younger DNA can combine to form a biochemically active substrate! Distinct TF binding, stronger purifying selection, less common variation hallmark cores v. young DNA. Check out @capra_lab's new work👇

https://t.co/tHGR9Pcjaz

[Capra Lab @capra_lab]

We are hiring! Multiple funded postdoctoral positions are available on projects at the intersection of bioinformatics, evolution, genetics, and electronic health records. Please share!
https://t.co/oToKR57ntO

[Laura L Colbran @lauracolbran]

I had a lot of fun helping @colinmbrand with this review! He's written a good summary of our main points here:

[Capra Lab @capra_lab]

Check out our lab manuscript template for some tricks, tips, and preferences (in both LaTeX and MS Word). Hoping it can be helpful to others! 🗒️✍️

[Sarah Fong @slifong]

We presented new work on cis and trans gene regulatory evolution at #cshlsysbio from @Hodges_Lab @capra_lab. As @Tyler_Hansen_VU said, it was great to meet people who do genomics and speak our language. We've got fresh inspiration after seeing such cool science. Back to work!

[Sarah Fong @slifong]

@EvonneMcArthur has been hard at work exploring the 3D genome differences between humans and Neanderthals!

[Evonne McArthur @EvonneMcArthur]

Ever wonder what the #3Dgenome folding🔺of a Neanderthal looked like?! Could it hold any clues as to where and why we have DNA 🧬and trait differences?

Check out our @capra_lab, Pollard lab & @gfudenberg lab collaboration @biorxivpreprint https://t.co/wec0qZiFWy

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[Sarah Fong @slifong]

New work w/ @capra_lab! Human enhancers can have multiple sequence ancestors. We show ancient core sequences integrated w/ younger derived sequences that bind unique TFs, are under less constraint, and link to increased genetic, gene expression variation. https://t.co/NQw1tqFqQW

[Capra Lab @capra_lab]

Excited to share our latest work with an amazing team, @ChazinWalter @alexmblee and @ZacNagel lab, on improving tumor #VUS interpretation with an active learning strategy: https://t.co/JO3Y3aWEaM

[Evonne McArthur @EvonneMcArthur]

Reminder to self (and others who it might help)! When creating a new @anacondainc 🐍environment, add some basic fonts so that your @matplotlib (or other) plots don't have Deja Vu Sans anymore!!

#boycottDejaVuSans

Tutorial here (thx @nekton4plankton): https://t.co/obm0qiDU3O

[Sarah Fong @slifong]

New work on the biochem of 🧬 replication and fork reversal out of Vanderbilt! Congrats @TKavlashvili

[Tata Kavlashvili @TKavlashvili]

I’m so excited to finally share my PhD work!! Here we developed a new biochemical approach to study fork reversal and nascent strand degradation. We uncover that uncoupled replication forks cause fork reversal and multiple degradation events without evicting the replisome. 🧬🐸

[Capra Lab @capra_lab]

New paper by graduate student Souhrid Mukherjee @AJHGNews! We use machine learning to predict disease gene pairs (DiGePred) to aid in the evaluation of patients with rare disease @VandyBioGrad @VUMCgenetics @UCSF_BCHSI @UCSF_Epibiostat @UDNconnect https://t.co/41o417hUdm

[Evonne McArthur @EvonneMcArthur]

Woohoo 🎉! Our @capra_lab paper on how Neanderthal ancestry contributes to the heritability of over 400 traits made it to @NatureComms . Check it out!! Tweetorial soon to come.