Sorek Lab

The Sorek Lab

[IdoAmitLab @IdoAmitLab]

What if we could turn the tumor’s deadliest tricks against it?
New @Cancer_Cell: Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells. Led by @GalYagel, @D_Rimini & @MVLocquenghien (1/15)
https://t.co/dzBILa2o26

[Erez Tzvi Yirmiya @ErezTzvi]

Happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life
https://t.co/ZxA5EJd4JH

[Romi Hadary @HadaryRomi]

📢 Preprint out!
Together with @reneechang and the amazing @SorekLab , we explored viral sponges to map their diversity and function.

Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris!

https://t.co/ZhHMK7KB6O

[Nitzan Tal @Nitzan_T]

📢Preprint out!
Excited to share my final work from the @Soreklab!

We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.

Found 3 new families targeting immune signaling!

[Patrick Hsu @pdhsu]

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases

In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

[Dziugas Sabonis @d_sabonis]

Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork!
https://t.co/PbEQ4ZHKyl

[Sorek Lab @SorekLab]

@IsbergRalph Thank you Ralph! I am honored to join the NAS.

[Tessera Inc. (Formerly BiomX Inc.) @Tessera_HLSQ]

🗓️Tomorrow! Ariel Cohen, VP Development Projects will present "The Challenges & Opportunities of the Development Pathway for Phage Therapy" 🦠at the Antimicrobial Chemotherapy Conference 2025, join virtually 14:35 CET!
Register👉 https://t.co/n29t3rQtKo
#PhageTherapy #Antibiotics

[Ilya Osterman @IlyaOsterman]

Another cADPR isomer involved in bacterial immunity has been discovered. For me, N7 was the least expected position; I was sure it would be N3, but no... So, there are two more positions for cyclization that should be discovered: N3 and -NH2. More Thoeris systems are waiting! :)

[Systems_Immunology_WIS @Sys_Immunology]

Congrats our very own @Sys_Immunology member PI @TanaWein for the impressive new paper @Nature together with @SorekLab- Shedding yet another piece of the (inflammasome-related) origins of immunology in bacteria!! Proud of you Tana and team!

https://t.co/jQs7rpljnY

[Sorek Lab @SorekLab]

Now published @ScienceMagazine: TIR signaling activates caspase-like immunity in bacteria

We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase

Congrats @FrancoisRousset & @IlyaOsterman!

https://t.co/cgGFIUqSLZ

[Seth Shipman @seth_shipman]

We just posted a new preprint where we found retrons in bacteria out in the real world, in dirt and water. We describe the first retrons in a handful of new species, show how they defend against phages, and use them to edit genomes. Read about it here: https://t.co/DiZmZOWCGs

[Sorek Lab @SorekLab]

Read more about our discovery in the thread by lead author @TanaWein 👇

https://t.co/7EYlUlvZL2

[Tanita Wein @TanaWein]

Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in @Nature 🥳 Thanks to all the people involved especially the Kranzusch lab and @SorekLab
https://t.co/ZnFeX8zPpY

[Sorek Lab @SorekLab]

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems

CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems

Congrats @TanaWein! Thanks Kranzusch lab!
https://t.co/yWUj5ZMjjO

[Sorek Lab @SorekLab]

@cbuch2 @IsbergRalph @theNASciences Thank you Carmen! 🙏

[Sorek Lab @SorekLab]

Thank you @theNASciences 🙏

It is an immense honor to be included in the same list as the giants in microbiology who received the Selman A. Waksman Award

[National Academy of Sciences @theNASciences]

We are honoring Rotem Sorek of @WeizmannScience with the 2025 Selman A. Waksman Award in Microbiology for groundbreaking discoveries on the immune system of bacteria. Congratulations! Learn about his research: https://t.co/CskDDISr5x #NASaward #microbiology

[Sorek Lab @SorekLab]

@ptrtsvetkov @theNASciences Toda Amraam!

[Sorek Lab @SorekLab]

@YMerbl @theNASciences Toda Yifat!

[Sorek Lab @SorekLab]

@AdrianoAguzzi @theNASciences Thank you for your kind words! 🙏

[Sorek Lab @SorekLab]

@amazeld @theNASciences Thanks Didier!

[Sorek Lab @SorekLab]

@taabaman @theNASciences Thank you Cornelius!