Steve Goldenberg

Founder @interfolio, 3xCEO, and Investor. Currently working on something big…

[Steve Goldenberg @stevegoldenberg]

@bcherny Does Fable allow any biology related projects to run? I run a biotech regulatory startup and Fable rejects every prompt I've given it

[Alex Banks @thealexbanks]

incredibly bullish on the future of tech + AI in London.

just to name a few:

• OpenAI just announced (last week) that London will become its largest research hub outside San Francisco
• Anthropic kicked off a 100+ person hiring spree across London and Dublin in 2025
• xAI set up shop in London in early 2025, based in X's former Piccadilly office, led by former DeepMind researcher Toby Pohlen
• Microsoft hired 24+ researchers from Google DeepMind for its London AI hub
• Google DeepMind announced its first automated research lab in the UK (opening 2026), focused on discovering new materials using AI and robotics
• Perplexity committed £80M to expand London offices
• Groq is opening its first UK data centre in London
• Cursor chose London as its European HQ

[Julien Bek @JulienBek]

https://t.co/hsKrbn1gEq

[Pete Sena @petesena]

For all my cracked AI builders - How to Run Claude Code From Your iPhone Using Tailscale, Termius, and tmux https://t.co/tirSTlScZj

[Harry Stebbings @HarryStebbings]

The quote I always think of when writing questions for a 20VC episode:

"Great minds discuss ideas. Average minds discuss events. Small minds discuss people. See, great minds can see into the future."

Eleanor Roosevelt

[Steve Goldenberg @stevegoldenberg]

@hthieblot AI driven computer vision system for growing Pluripotent Stem Cells (the key technology for cell therapy, which is going to cure cancer).

[Jason Kelly @jrkelly]

There’s never been a better time to be curious

[Steve Goldenberg @stevegoldenberg]

@HarryStebbings Obsession is table stakes. Anything else doesn’t work…

[molson 🧠⚙️ @Molson_Hart]

https://t.co/b9K9yNW5Dq

[Steve Goldenberg @stevegoldenberg]

@joshuamarch Congratulations!

[Vinod Khosla @vkhosla]

I very much count on innovation coming from orthogonal sectors! In the last forty years I have watched innovation, no big innovation has come from people who are experts the field! It's first principles thinkers who are willing to look past current expert knowledge. Uber, AirBnB, SpaceX, Rocketlab, Tesla, plant proteins, fusion, solar, Media, retailing, ....

[Steve Goldenberg @stevegoldenberg]

@Atelfo Love to. We’re building new bioreactors. When will you be here?

[Steve Goldenberg @stevegoldenberg]

@aphysicist 👋🏻

[Elliot Swartz @elliotswartz]

Combining computational fluid dynamics to optimize bioreactor geometry and parameters suggests existing techno-economic models may underestimate attainable yields

Glad @GoodFoodInst could fund this project

https://t.co/MuT9KKY7B2

[Steve Goldenberg @stevegoldenberg]

@dkrajendra Every day me thinks

[Steve Goldenberg @stevegoldenberg]

Co-sign. The struggle is worth it.

[Startup Archive @StartupArchive_]

The 9 traits Sam Altman looks for to identify founders who can build a $10 billion company

“It’s difficult to hear an idea at the very early stage and say: ‘Yeah, this idea has what it takes to be a $10 billion company.’ However, I think you can, with practice, identify founders that have a chance at creating one of those companies.’”

The first four traits Sam looks for comes from gmail creator Paul Buchhiet: obsession, focus, frugality, and love.

Next, Sam looks for intelligence:

“You can give a founder an idea, but the problem is they need to come up with new ideas for the company basically every week… We tried an experiment at Y Combinator where we funded 20 teams of strong founders that didn’t have ideas but otherwise were really good, and they all failed. What we learned is that good founders have ideas all the time.”

#6 is communication skills:

“So much of your job as a founder is about communication—every time you hire someone, go to raise money, try to sell the product, and set a direction for the company. A huge amount of a founder’s job is being an evangelist for the company. If you don’t have strong communication skills or you don’t develop them quickly, you’re at a big disadvantage.”

#7 is execution speed. How quickly can you generate a hypothesis, test it, and implement it? Sam observes that most slow-moving founders who went through Y Combinator didn’t go on to be successful: “A relentless cadence of execution is incredibly correlated with success.”

#8 is the rate of improvement of the founder:

“If you look at a founder who comes to meet you for a seed round and compare that founder to Brian Chesky, you will be disappointed 100% of the time. That’s the wrong comparison… You should look at the at the growth rate of the founder… Humans always underestimate exponential growth.”

#9 is the right motivations:

“There a lot of people who start a startup because they think it’s a way to get rich quickly, and unfortunately it’s just not. So startups have become the new default career trajectory for ambitious people… This does not work given the amount of pain you have to suffer for a startup… In our portfolio at YC, every time we thought a company was going to go really well and didn’t, the founder did not have a deep sense of mission.”

Video Source: @ycombinator

[Steve Goldenberg @stevegoldenberg]

@johncumbers 60% of @sterlingbiomachines will be there :) And we're staying after for a bit as well.

[Ryan McIntosh @RyanMcIntosh33]

Here's @ycombinator 's playbook for hard tech companies based on this awesome conversation (highly recommend watching)

Here's the TL;DR:
-Start Small to Demonstrate Feasibility and Gain Traction
-Secure Early Commercial Validation
-Focus on Solving a Significant Problem
-Think Like a Software Company
-Innovate Strategically and Use Off-the-Shelf Components
-Leverage Regulatory Changes and Incentives
-Build a Mission-Oriented Team
-Prepare for Intensive Fundraising
-Embrace and Manage Technical Risks
-Cultivate Resilience and Flexibility

The full breakdown below 🧵

[Steve Goldenberg @stevegoldenberg]

This is how to build strong and lasting relationships in entrepreneurship and adventure capital. Thanks @stefanobernardi and Unruly Capital

[Steve Goldenberg @stevegoldenberg]

@BenGeskin @Shadow_Official Have you used this on your Vision Pro via the Mac screen extension? Seems like it could be an amazing game experience if it works