Kamyar Keshavarz

PharmD, MSc, PhD Student @ Ebrahimkhani lab , Dep of Bioengineering, University of Pittsburgh, BioSystem Engineering #synbio #devbio #organoid #UPSaclay #UPitt

[Ya'el Courtney, PhD @ScienceYael]

Just updated my HHMI Gilliam Fellowship application guide for the 2026 competition, which brings major program changes.

Int'l PhD students can now apply. MD-PhDs are eligible. & a new postdoc pathway that can extend HHMI support up to 7 years total.

https://t.co/BSQ11pBpfW

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

Insanely cool paper! @ketanpatelimmo1

[Stanley Qi @stanleyqilab]

Read more about our work in neuroscience on recent paper: CRISPR-TO a programmable tool to reorganize the transcriptome
Paper: https://t.co/dLk5HMkCs6 @StanfordBrain

[Jamie Blundell @jrblundell]

In 1999, Tom Maniatis discovered something remarkable: neurons achieve self-avoidance via stochastic methylation of the protocadherin gene cluster.

We've just discovered this locus is an evolvable in-vivo barcode across the human tissues: https://t.co/DMyHA5TIS0 🧵

[Mo Ebrahimkhani @MoEbrahimkhani]

Best wishes for 2026 from our Lab at
https://t.co/whutaDfNlz
We look forward to a year defined by discovery, curiosity, and bold exploration.
Stay tuned for more news coming soon!
#organogenesis #stemcellmodels #syntheticbiology #howtissuesarebuilt

[Roth_Lab @Roth_Lab]

Excited to present the first major work after starting our lab at Stanford and the Arc this year: CRISPR-All, a unified genetic perturbation language for programming any major type of genetic perturbation simultaneously, in any combination, at genome scale, in human cells.

[Brian Hie @BrianHie]

Today in @Nature, in work led by @aditimerch, we report the ability to prompt Evo to generate functional de novo genes.

You shall know a gene by the company it keeps! 1/n

[Martin Pera @martinperaJAX]

CD43, but not CD41 or GPI-80, marks first definitive haematopoietic stem cells in the human embryo https://t.co/qgL8pBt0oZ

[Bruno Di Stefano @DiStefano_Lab]

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵https://t.co/D7fnkJgNQ6

[Pierce @PierceOgdenJ]

Excited to announce mBER, our fully open AI tool for de novo design of epitope-specific antibodies. To validate, we ran the largest de novo antibody experiment to date: >1M designs tested against 145 targets, measuring >100M interactions. We found specific binders for nearly half the targets, with up to 40% hit rates. Thread below:

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature.

This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at @CRGenomica

https://t.co/BI12Ir7fyz

[Development @Dev_journal]

In this Review, @BernaSozen_ , Patrick Tam and @martinperaJAX summarize how recent studies of embryo models have advanced our understanding of cell state transitions of the pluripotent human epiblast and highlights some key remaining questions:
https://t.co/pFLM5s3bUS

[Itai Yanai @ItaiYanai]

🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.

[Logan Thrasher Collins @LoganTCollins]

I love Church's and Langer's approach to running their research programs. Unfortunately, today's academic research culture is not very conducive to developing this type of environment. Thinking about ways of circumventing such obstacles...
https://t.co/7AqsuehpM2

[Xavier Trepat @XavierTrepat]

Very nice focus issue @CurrentBiology on Physics and Biology.
https://t.co/woaogl90PW
Some of us wrote a perspective article on "Where physics and biology meet" led by @WallaceUcsf and Deborah Taylor.
https://t.co/dtqcUpkt8U

[Eyo Eyo, PhD @Eyowhite3]

Best practices for data visualisation:

[Eric Topol @EricTopol]

The prominent role of the gut microbiome in modulating response to stress and circadian rhythm
https://t.co/q1yQWz5w7W @Cell_Metabolism open-access, by @jfcryan @gabriel_tofani @UCC and colleagues

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[A. Sánchez Alvarado @Planaria1]

Alfonso Martinez Arias @AMartinezArias starts the first half of the last afternoon session

Alfonso exploits the properties of stem cells to study the genesis of systems that lead and sustain patterns, forms and functions of embryonic processes

https://t.co/hLwFWZlWcQ

The data from gastruloids suggest that the frog organizer may have been split into two in mammals

#spemannmangold2024 @UniFreiburg @UPFBarcelona

[Fabian Theis @fabian_theis]

Thrilled to share our „PRedictor Of PHEnoTypes“ model Prophet! Led by @Alejandro__TL & @_yji_, Prophet is a transformer-based model that predicts outcomes for unseen experiments. It aims to understands biology by learning across assays and phenotypes over 4.7M+ experiments.