@ZhengyangG51844 I wonder if this is one way to achieve it; sampling from latent space. Or can design a very specific probalistic or energy-based method to distribute over an arbitrary amount of output length
@chang_m_yun Hey, im back! Sorry, still have no idea how X worksโฆ I wonder if we can use evo2 sequence embedding and co-train it with epigenomic signals and see what will happen (similar to Evo2HiC). Variant prediction across distal sequences is an interesting challenge
@chang_m_yun Love to see efforts benchmarking! One perspective I always have is that s2f models are always trained reference genomes, and it doesnโt really make sense to do variant prediction. Maybe there should be a concerted effort for perturbseq/crispr assays to improve this capability