Got out of the nucleus! Tested ~30,000 tiles from human RNA-binding proteins, found lots of domains that downregulate RNA&built an inducible synthetic RNA-binding protein for keeping target RNA at constant intermediate levels: https://t.co/g6d7XEZOlY So many follow-up projects!
Take a look at this recently published study in LSA: A large-scale cancer-specific protein–DNA interaction network @fuxmanlab@annaabananabell@yunwei_lu@BU_Tweets
https://t.co/wYjFrIRM0k
Excited to share our latest preprint on TF isoforms! Excellent tweetorial by @kaia_mattioli This is a large collaboration with the a Vidal, Bulyk, Sahni, and Salomonis labs and many other authors. The project was led by @LukeLambs , Kaia, and @cssantoso_
We are very excited to see our paper published in @NatureComms led by the amazing Anna Berenson (@annaabananabell)! We introduce paired yeast one-hybrid (pY1H) assays to study cooperativity and antagonism between transcription factors (TFs). https://t.co/4W17LbY03o 1/6
Epstein-Barr virus evades restrictive host chromatin closure by subverting B cell activation and germinal center regulatory loci https://t.co/fllMXZ9Sga
Our latest paper is out today (with @axmukund@JoshTycko and many other talented trainees): High-throughput functional characterization of combinations of transcriptional activators and repressors, at Cell Systems https://t.co/XinGzuRmNJ