Taha Y. Taha

Husband, father, virologist, pharmacist, soccer player, and chess enthusiast 🦠🧬😷 🥼 🔬⚽♞
Working on HBV and SARS-CoV-2 @TheOttLab @GladstoneInst

[Taha Y. Taha @ttaha801]

Thrilled to share our latest work identifying that #SARSCoV2 #Omicron variants harboring an L260F mutation in NSP6 have enhanced replication and pathogenesis. A not so brief thread 🧵

[Alice Ting @aliceyting]

Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing.

https://t.co/iAJUj6jBQ4

[Ryan Corces @ryancorces]

Just posted a preprint on a huge new single-cell study of Parkinson’s and its application to understanding noncoding variation. 🧵below. Led by Shreya Menon and Adam Turner and in collab w/ GP2 (@ASAP_Research), @BelloyMichael, @ZihHuaFang and others. https://t.co/tBKZgq5bQ7

[Christine Rabinak @BrainsBeesBikes]

The first time you start a research lab, there’s no manual.

So I made one.

A practical toolkit for postdocs and early-career faculty launching their first lab: hiring, startup planning, collaborations, and building a sustainable research program.

https://t.co/a30LLykjKq

[Brian Hie @BrianHie]

Evo 2, our genome language model that generalizes:
- across biological prediction and design tasks,
- across all modalities of the central dogma,
- across molecular to genome scale, and
- across all domains of life,
is published today in @Nature.

[Florian Krammer @florian_krammer]

1) We have a new preprint paper out about population immunity to H5N1 and H5N5. Results are in line with what others have seen but there are two new findings. https://t.co/wVSfSWdUaG

[Mehdi Bouhaddou, PhD @DoctorBou]

Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾
https://t.co/4o9jCCMcuG

[Tulio de Oliveira @Tuliodna]

SARS-CoV-2 continue to surprise us with evolutionary jumps. In this pre-print, we describe the Identification and genomic characterisation of BA.3.2: a highly divergent BA.3-related SARS-CoV-2 lineage from southern Africa. A thread 🧵 https://t.co/BJIQJlhTTe

[Feng Zhang @zhangf]

Excited to share our new work on immune aging! We explored whether the liver could serve as a temporary "factory" to produce immune factors that decline with aging, potentially helping to rejuvenate aged immunity. @mircoscopy.

[Stefan Pöhlmann @snpoehlm]

BA.3.2 overview

[Taha Y. Taha @ttaha801]

@LongDesertTrain Do all the sequences available have the accessory protein deletion?

[LALIGA @LaLiga]

🦁 El efecto imposible de @willliamsssnico.

[Brian Hie @BrianHie]

Today in @Nature, in work led by @aditimerch, we report the ability to prompt Evo to generate functional de novo genes.

You shall know a gene by the company it keeps! 1/n

[David R. Liu @davidrliu]

Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases.
(1/15)
https://t.co/zs0qu5bhXx

[Arjun Raj @arjunrajlab]

So awesome to have this great paper from @SamReffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)!

https://t.co/9JSsuN94ma

[nature @Nature]

Nature research paper: Convergent genome evolution shaped the emergence of terrestrial animals

https://t.co/Zn4Ud0SUJA

[Cornelius Gati @CorneliusGati]

Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵
https://t.co/E2fZXw2Pom

[US Chess @USChess]

Danya was a Chess Life magazine columnist from 2014 through 2020, writing a monthly column on endgames.
Now, all of his columns can be downloaded as one .pdf file here (no US Chess membership required):

https://t.co/0O2MvthaM5

[Taha Y. Taha @ttaha801]

💔
RIP Danya

[Charlotte Chess Center @CLTchesscenter]

The Naroditsky family shares the sad news of Daniel’s unexpected passing. Daniel was a talented chess player, educator, and beloved member of the chess community. We ask for privacy as the family grieves.

[GothamChess @GothamChess]

I've been sitting here numb for the past hour staring at this news. The world lost a brilliant man today. May his memory live on forever and may we always cherish his contributions to our beautiful game.

[plasmidsaurus @plasmidsaurus]

🦖 Something HUGE just hatched.

Plasmidsaurus now offers RNA sequencing for gene expression analysis with:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results that let you explore changes in genes and pathways

Explore Plasmidsaurus RNA-Seq today.