What a b(y)east! Using S. pombe, we demonstrate that replication fork component Mrc1 (CLASPIN in mammals) functions to recycle ♻️parental H3-H4 to BOTH leading and lagging strand ☯️! Affecting recycling symmetry leads to a clonal loss of heterochromatin and #epigenetic memory⬇️🧵
This is the summary of what we have shown in this paper. The take-home message is that facultative heterochromatin is slowly formed by the H2Aub1-reading PRC2.2 complex in a stepwise manner.
10/11
So excited to share my current work being published in Cell!
LiTEC enables genome-wide studies (For now, proteomics) of endogenous condensates in living cells!
Thank you so much for the endless support, @IbrahimCisse_ , and also all the members of our lab and @mpi_ie !!
🚨Preprint alert🚨 Excited to share the #preprint version of our work @MundlosLab ! Curious about how a transposable element (TE) insertion can cause developmental phenotypes? 🧬🦠🐁
Check the 🧵 below and the full version on BiorXiv:
https://t.co/C8Yijflrnf
My lab is hiring a postdoc, don't hesitate to apply! Lots of opportunities to work on Hi-C/Micro-C and super-resolution imaging in Drosophila and mESCs.
We're hiring!
We have a funded postdoc available and encourage anyone interested in epigenetics and/ or gametogenesis to apply. Experience in mouse genetics/ development especially welcome!
Deadline: 1 October
Apply here: https://t.co/yWYqQt5YRs
Please retweet!
My science journey will continue in 🇨🇭 next year and I couldn‘t be more excited that it‘s at the @biozentrum! If you want to join our team in Basel get in touch!
Great news to share: The University Council has appointed Claudia @KellerValsecchi as the new Assistant Professor of Molecular Biology @biozentrum. She will join our community in August 2025. We are looking forward to welcoming our new colleague. https://t.co/lmUnGO5jW1
Hurry up & register for the upcoming Max Planck Freiburg Epigenetics Meeting in December 2024!
Join us in Freiburg for an opportunity to connect with leading minds, expand your network, and contribute to the landscape of epigenetic research:
https://t.co/nA7IUc2RYi
After a successful faculty recruitment that brought in two stellar new Assistant Profs, we're not resting on our laurels: @WashUGenetics is hiring again. I'm on the search committee this year, and we're prepared to make a bunch of offers. Let me tell you why you should apply 1/6
I am so excited to share that I am starting this Fall as an Investigator at @LDI_ILD and Assistant Professor at McGill @McgillGBDO! I’ll be recruiting students and a research asssistant- Get in touch if you’re interested in chromatin and gene regulation!
https://t.co/600c2smYfY