Hrishi Venkatesh

Postdoctoral Researcher at the Fong Lab at the Fred Hutchinson Cancer Center. Studying the role of B cells and CD4 T cells in cancer immunotherapies

[Paolo Tarantino @PTarantinoMD]

Impressive job of post-publication Twitter peer review on this paper!

With the effect size appearing inexplicably massive, plus the many inconsistencies in study conduct and reporting, it’s safe to assume the “time-of-day IO” question still fully open. https://t.co/ap3lfksROl

[Eric Topol @EricTopol]

What drives immunosenescence—the degradation of function our immune system with aging that increases the risk of age-related diseases?
Today @SciImmunology the B cells are identified as the bad actors because they induce T cell (CD4) dysfunction and inflammaging (work in experimental model). When B cells are eliminated, healthspan improves.
https://t.co/N4CiK7SszD

[Chrystal Paulos @Chrystal_Paulos]

Byrne’s group (Cancer Immunology Research) shows CD4⁺ T cells mediate rejection of MHC-deficient pancreatic tumors after anti-CD40 + dual ICB.
CD4 (not CD8)T cells drive it, reprogramming MHCII⁺ stromal & endothelial cells for tumor control. https://t.co/mLoI5ehA3a

[E. John Wherry @EJohnWherry]

What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. https://t.co/i8qksekdNM

[Hrishi Venkatesh @venka201]

Excited to share our review with @lawfong on CD4+ T cell dysfunction in cancer! We highlight the diverse functional states of CD4+ T cells throughout their differentiation — from priming in tumor-draining lymph nodes to terminal differentiation in tumors.
https://t.co/TrzyJU17qK

[Hrishi Venkatesh @venka201]

@DelgoffeLab Congratulations!

[Chrystal Paulos @Chrystal_Paulos]

Interesting!

[Hrishi Venkatesh @venka201]

Whether you're riding with us, donating, or joining our fun games — you’re part of the cure! Thanks!

[Hrishi Venkatesh @venka201]

The Fong Lab at Fred Hutch is excited to join Obliteride 2025 to raise funds for life-changing cancer immunotherapy research!

[Hrishi Venkatesh @venka201]

You can also support our cause by donating here: https://t.co/gn104V9IIj

[Big Ten Cancer Research Consortium @BigTenCRC]

This month, the Big Ten Cancer Research Consortium highlights our member institution @fredhutch Cancer Center and Lawrence Fong, MD, who serves as scientific director of the Immunotherapy Integrated Research Center at Fred Hutch.

Read more: https://t.co/3XPv6Ilsoj

[Hrishi Venkatesh @venka201]

@aaronmring @Yile_Dai @Nature @fredhutch @FH_IRC @YaleCancer @YaleIBIO @Seranova Congratulations!

[Fred Hutch Cancer Center @fredhutch]

A landmark study published in @Nature by @aaronmring et al. has revealed that autoantibodies — immune proteins traditionally associated with autoimmune disease — may profoundly influence how cancer patients respond to immunotherapy. https://t.co/M8aDY8g4gP

[David Usharauli @3DiMMUNE]

In my view, the question of T helper cell differentiation should be divided into: (A) stochastic phenotype acquisition by naïve T cells via innate signals, and (B) pathological responses from cross-reactive, pre-existing memory T cells.

#immunology

https://t.co/Agzuztoa7e

[Waggoner Lab @LabWaggoner]

CINTER-seq enables in situ capture and multimodal profiling of interacting cells in living mice, uncovering specific LAG3-MHC II-mediated CD4+ T cell-cancer cell interactions & tumor-reprogrammed neutrophils
https://t.co/W2k12cclGi @ImmunityCP

[Hrishi Venkatesh @venka201]

@NNJarjourPhD @VersitiResearch @MedicalCollege @childrenswi Congratulations @NNJarjourPhD! 👏🎊🍾🍾

[Hrishi Venkatesh @venka201]

@OveracreLab Congratulations! 🎊

[Hrishi Venkatesh @venka201]

A really important work by @MaxKrummel and colleagues highlighting key differences in the immune cell composition/interactions in tumors between mice and humans.

[ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE @DucheneJohan]

A comparison of mouse vs human tumor microenvironments shows a major difference.

Mouse TMEs have more macrophages, while human TMEs have more T cells.

Chemokine expression patterns are also different.

Learn more: https://t.co/HdTwiSULzj

[Hrishi Venkatesh @venka201]

@IngunnStromnes Wow congratulations Zoe!